Glucose metabolism and its signaling in cancer and immune regulation
林慧觀
Hui-Kuan Lin
林慧觀 Hui-Kuan Lin
Director of Prostate Cancer Center
Current Position
Department of Cancer Biology
Wake Forest University School of Medicine
Education
National Taiwan University, Taipei, Taiwan, Taiwan, BS, 1993, Pharmacy
National Taiwan University, Taipei, Taiwan, Taiwan, MS, 1995, Pharmacology
University of Rochester, Rochester, NY, PHD, 2002, Pathology (Cancer Biology)
Curriculum Vitae
Zhang, W., Wang, G., Xu, ZG., Tu, F., Dai, J., Chang, Y., Chen, Y., Lu, Y., Zeng, H., Cai, Z., Han, F., Xu, C., Jin, G., Sun, L., Pan, BS., Lai, SW., Hsu, CC., Xu, J., Chen, Z., Li, HY., Seth P., Hu, J., Zhang, X., Li, H., Lin, HK. Lactate is a natural suppressor of RLR signaling by targeting MAVS. Cell. 2019 Jun 27;178(1):176-189.e15. doi: 10.1016/j.cell.2019.05.003. Epub 2019 May 30.
Wang G, Long J, Gao Y, Zhang. W, HanF, XuC, SunL, YangSC, Lan J, HouZ, CaiZ, Jin G, Hsu CC, Wang YH, Hu J, Chen TY, Li H, Lee MG, Lin HK.SETDB1-mediated methylation of Akt promotes its K63-linked ubiquitination and activation leading to tumorigenesis. Nat. Cell Biol. 2019 Feb;21(2):214-225.
Chan CH, Morrow JK, Li CF, Gao Y, Jin G, Moten A, Stagg LJ, Ladbury JE, Cai Z, Xu D, Logothetis CJ, Hung MC, Zhang S, Lin HK. Pharmacological Inactivation of Skp2 SCF Ubiquitin Ligase Restricts Cancer Stem Cell Traits and Cancer Progression. Cell 154(3):556-68, 8/2013.
Chan CH, Li CF, Yang WL, Gao Y, Lee SW, Feng Z, Huang HY, Tsai KK, Flores LG, Shao Y, Hazle JD, Yu D, Wei W, Sarbassov D, Hung MC, Nakayama KI, Lin HK. The Skp2-SCF E3 Ligase Regulates Akt Ubiquitination, Glycolysis, Herceptin Sensitivity, and Tumorigenesis. Cell 149(5):1098-111, 5/2012.
Yang WL, Wang J, Chan CH, Lee SW, Campos AD, Lamothe B, Hur L, Grabiner BC, Lin X, Darnay BG, Lin HK. The E3 ligase TRAF6 regulates Akt ubiquitination and activation. Science 325(5944):1134-1138, 8/2009.
林琬琬
Wan-Wan Lin
12:00 - 14:00
科技新知研討會
午餐 科技新知研討會-台灣活性脂質
Chih-Hao Wang
Chih-Hao Wang
Current Position
Education
Curriculum Vitae
Wang CH et al., Disruption of mitochondria-associated ER membranes impairs insulin sensitivity and thermogenic function of adipocytes. Front. Cell Dev. Biol. 2022.
Sugimoto S, Mena HA, Sansbury BE, Kobayashi S, Tsuji T, Wang CH et al., Brown adipose tissue-derived MaR2 contributes to cold-induced resolution of inflammation. Nat Metab. 2022.
Onikanni AS, …Olusola AO*, Wang CH* (co-corresponding author). Therapeutic efficacy of Clompanus pubescens leaves fractions via downregulation of neuronal cholinesterases/Na+-K+ATPase/IL-1β, and improving the neurocognitive and antioxidants status of streptozotocin-induced diabetic rats. Biomed Pharmacother. 2022.
Shamsi F*, Wang CH* (co-first author), Tseng YH. The evolving view of thermogenic adipocytes - ontogeny, niche and function. Nat Rev Endocrinol. 2021.
Wen-Lung Ma
12:00 - 14:00
壁報論文競賽
13:00 - 14:20
陳烱霖轉譯醫學講座特別演講致德堂
Communication between cancer cells and immune cells during tumor progression
楊慕華
Muh-Hwa Yang
楊慕華 Muh-Hwa Yang
Chair professor of Institute of Clinical Medicine, Yang Ming Chiao Tung University
Current Position
Institute of Clinical Medicine, National Yang Ming Chiao Tung University
Education
M.D., National Yang-Ming University
Ph.D., National Yang-Ming University
Resident and clinical fellow of Division of Hematology-Oncology, Taipei Veterans General Hospital
Curriculum Vitae
Chen HY, Hsieh, CH, Lin PH, Chen YT, Hsu DS, Tai SK, Chu PY, Yang MH*. Snail regulated microRNA-21 suppresses NLRP3 inflammasome activity to enhance cisplatin resistance. J Immunother Cancer 2022;10:e004832.
Ou DL, Chen CW, Hsu CL, Chung CH, Feng ZR, Lee BS, Cheng AL, Yang MH*, Hsu C*. Regorafenib enhances antitumor immunity via inhibition of p38 kinase/Creb1/Klf4 axis in tumor-associated macrophages. J Immunother Cancer 2021;9:e001657.
Liao TT, Lin CC, Jiang JK, Yang SH, Teng HW, Yang MH*. Harnessing stemness and PD-L1 expression by AT-rich interaction domain-containing protein 3 in colorectal cancer. Theranostics 2020;10:6095-6112.
Li CF, Chen JY, Ho YH, Hsu WH, Wu, LC, Lan HY, Hsu DS, Tai SK, Chang YC*, Yang MH*. Snail-induced claudin-11 prompts collective migration for tumor progression. Nat Cell Biol 2019;21:251-262.
Hwang WL*, Lan HY, Cheng WY, Huang SC, Yang MH*. Tumor stem-Like cells-derived exosomal RNAs prime neutrophils for facilitating tumorigenesis of colon cancer. J Hematol Oncol 2019;12:10.
鄭子豪
TH Cheng
14:30 - 15:30
學會特別演講
Can a better understanding of physiology be translated to better births
Susan Christina Wray
Susan Christina Wray
Professor
Current Position
University of Liverpool
Education
BSc University College London
PhD University College London
Curriculum Vitae
Wray S, Arrowsmith, S & Sharp, A (2023) Pharmaceutical interventions in labour and delivery Annu. Rev. Pharmacol. Toxicol.. 63:
Wray S & Arrowsmith S (2021) Uterine Excitability and Ion Channels, and Their Changes with Gestation and Hormonal Environment Ann Rev PhysiolFeb 10;83:331-357.
Muttenthaler M, Andersson Å, Vetter I, Menon R, Busnelli M, Ragnarsson L, Bergmayr C, Arrowsmith S, Deuis JR, Chiu HS, Palpant NJ, O'Brien M, Smith TJ, Wray S, Neumann ID, Gruber CW, Lewis RJ, Alewood PF (2017). Subtle modifications to oxytocin produce ligands that retain potency and improved selectivity across species. Science Signaling5;10(508). doi: 10.1126/scisignal.aan3398
Reversing nonalcoholic fatty liver disease via antagonizing stress-induced Apolipoprotein J
孫宏羽
Hung-Yu Sun
孫宏羽 Hung-Yu Sun
Assistant professor/助理教授
Current Position
Department of Physiology, National Cheng Kung University
Education
1998-2002, B.S., Department of Zoology, National Chung Hsing University
2002-2004, M.S., Institute of Molecular Medicine, National Cheng Kung University
2004-2011, Ph.D., Institute of Basic Medical Sciences, National Cheng Kung University
2012-2018, Postdoctoral Fellow, National Cheng Kung University
Curriculum Vitae
Shuangdi Duan, Nong Qin, Jiayi Pi, et al. Antagonizing apolipoprotein J chaperone promotes proteasomal degradation of mTOR and relieves hepatic lipid deposition. Hepatology, 2022. (Corresponding Author) (Accepted)
Pin-Nan Cheng, Hung-Yu Sun, I-Che Feng et al. Interdependence of glycemic and lipid modulation in cured chronic hepatitis C patients by direct-acting antiviral agents. J Microbiol Immunol Infect. 2022;S1684-1182(22)00095-0 (Co-first author)
Hung-Yu Sun, Tzu-Ying Chen, Yu-Ching Tan, et al. Sterol O-acyltransferase 2 chaperoned by Apolipoprotein J facilitates hepatic lipid accumulation following viral and nutrient stresses. Commun Biol. 2021;4(1):564.
Sun HY, Cheng PN, Tseng CY, et al. Favouring modulation of circulating lipoproteins and lipid loading capacity by direct antiviral agents grazoprevir/elbasvir or ledipasvir/sofosbuvir treatment against chronic HCV infection. Gut. 2018;67(7):1342-1350.
Sun HY, Lin CC, Tsai PJ, et al. Lipoprotein lipase liberates free fatty acids to inhibit HCV infection and prevent hepatic lipid accumulation. Cell Microbiol. 2017;19(4):e12673
李昆澤
Lee kun-ze
16:10 - 16:40
新進人員研討會
The role of exosome in multiple drug resistance and tumor progression
林佑融
Yu-Jung Lin
林佑融 Yu-Jung Lin
Assistant Research Fellow 助理研究員
Current Position
Cardiovascular and Mitochondrial Related Disease Research Center, Hualien Tzu Chi hospital
Education
Ph.D. Institute of Molecular Biology, National Chung-Hsing University
M.S. Graduate Institute of Basic Medical Science, China Medical University,
Curriculum Vitae
1. T cells mediate kidney tubular injury via impaired PDHA1 and Autophagy in type 1 diabetes. J Clin Endocrinol Metab. 2022 Aug 18;107(9):2556-2570. doi: 10.1210/clinem/dgac378. (Co-corresponding), IF= 6.134
2. Artemisia argyi extract induces apoptosis in human gemcitabine-resistant lung cancer cells via the PI3K/MAPK signaling pathway. J Ethnopharmacol. 2022 Dec 5;299:115658. doi: 10.1016/j.jep.2022.115658. Epub 2022 Sep 6. (Co-corresponding) , IF= 5.195
3.RGS4 deficit in prefrontal cortex contributes to the behaviors related to schizophrenia via system xc- mediated glutamatergic dysfunction in mice. Theranostics. 2018; 8(17):4781-4794. doi:10.7150/thno.25189. (Co-First author), IF=11.6
4. Tumor Hypoxia Regulates Forkhead Box C1 to Promote Lung Cancer Progression. Theranostics. 2017; 7(5):1177-1191. doi:10.7150/thno.17895.( First author), IF=11.6
5.Combination of fucoidan-based magnetic nanoparticles and immunomodulators enhances tumour-localized immunotherapy. Nature Nanotechnology volume 13, pages746–754 (2018). (Second author),IF=40.523
李昆澤
Lee kun-ze
16:40 - 17:10
新進人員研討會
Meet the “point of no return” of renal fibrosis- Can we conquer it?
葉儀君
Yi-Chun Yeh
葉儀君 Yi-Chun Yeh
Assistant professor 助理教授
Current Position
Department of Physiology and Pharmacology
Education
2005.09-2010.12 Ph.D., Basic Medical Science
Institute of Basic Medical Science, National Cheng Kung University
2003.09-2005.06 M.S., Physiology
Department of Physiology, Medical College, National Cheng Kung University
1999.09-2003.07 B.S., Biology
Department of Biology, Tunghai University
Curriculum Vitae
1. Dulloo I, Atakpa-Adaji P, Yeh YC, Levet C, Muliyil S, Lu F, Taylor CW, Freeman MA. iRhom pseudoproteases regulate ER stress-induced cell death through IP3 receptors and BCL-2. Nat. Commun., 10;13(1):1257.
2. Grieve AG,Yeh YC, Chang YF, Huang HY, Zarcone L, Breuning J, Johnson N, Stríšovsky K, Brown MH, Parekh AB, Freeman M. Conformational surveillance of Orai1 by a rhomboid intramembrane protease prevents inappropriate CRAC channel activation. Mol. Cell., 1;81(23):4784-4798.
3. Yeh YC, Lin YP, Kramer H and Parekh AB. Single nucleotide polymorphisms in Orai1 associated with atopic dermatitis inhibit protein turnover, decrease calcium entry and disrupt calcium-dependent gene expression. Hum. Mol. Genet., 21;29(11):1808-1823.
4. Yeh YC, Lin HH, and Tang MJ. Dichotomy of DDR1 functions in epithelial cells. Biochem. Biophys. Acta. Mol. Cell Res., 1866(11):118473. (Review paper).
5.Yeh YC, and Parekh AB. Calcium Entry Channels in Non-Excitable Cells. Chapter of CRAC channels and Ca2+-dependent gene expression. Editors: Kozak JA and Putney JW. CRC Press. (Contribute a Book chapter).
李昆澤
Lee kun-ze
17:10 - 17:40
新進人員研討會
Fear memory in the ventral hippocampus disrupts sleep in mice
蕭逸澤
Yi-Tse Hsiao
蕭逸澤 Yi-Tse Hsiao
Associate professor 副教授
Current Position
School of Veterinary Medicine at National Taiwan University
Education
2013-Current Ph.D. in Veterinary Medicine
2008-2013 Ph.D. Student in Veterinary Medicine
National Taiwan University, Taipei, Taiwan
2007-2008 M.S. Student in Veterinary Medicine
National Taiwan University, Taipei, Taiwan
2002-2006 B.S. in Veterinary Medicine,
National Taiwan University, Taipei, Taiwan
Curriculum Vitae
Yun Lo, Yi-Tse Hsiao*, Fang-Chia Chang* (2022, May) Use electroencephalogram entropy as an indicator to detect stress-induced sleep alteration. Applied Sciences 12.10: 4812.
Yun Lo, Pei-Lu Yi, Yi-Tse Hsiao, Fang-Chia Chang (2021, Dec) Hypocretin in locus coeruleus and dorsal raphe nucleus mediates inescapable footshock stimulation (IFS)-induced REM sleep alteration. SLEEP
Yi-Tse Hsiao, Ta-Ching Chen, Pin-Huan Yu, Ding-Siang Huang, Fung-Rong, Hu, Cheng-Ming Chuong, Fang-Chia Chang (2020, Nov) . Connectivity between nidopallium caudolateral and visual pathways in color perception of zebra finches. Scientific Reports, 19382 https://www.nature.com/articles/s41598-020-76542-z
Wan-Ting Liao, Chao-Lin Chang, Yi-Tse Hsiao (2020, Jun) Activation of cannabinoid type 1 receptors decreases the synchronization of local field potential oscillations in the hippocampus and entorhinal cortex and prolongs the interresponse time during a differential‐reinforcement‐of‐low‐rate task. European Journal of Neuroscience https://onlinelibrary.wiley.com/doi/abs/10.1111/ejn.14856
Yi-Tse Hsiao, Yun Lo, Pei-Lu Yi, Fang-Chia Chang (2019, Jun). Hypocretin in median raphe nucleus modulates footshock stimuli-induced REM sleep alteration. Scientific Reports, 9:8198. https://www.nature.com/articles/s41598-019-44731-0
李昆澤
Time / 時間
Topic / 主題
Speaker / 講員
Moderator / 座長
Abstract / 摘要
10:00 - 11:00
壁報論文展示
11:00 - 12:00
會員大會
會員大會
12:00 - 13:30
生理學會餐會
13:40 - 14:10
聯合研討會—生理與藥理學會代謝疾病
Risk Factors for Diabetes, Sarcopenia, and Chronic Kidney Disease- Advanced Glycation End Products and Acrolein
劉興華
Shing-Hwa Liu
劉興華 Shing-Hwa Liu
Professor 教授
Current Position
Institute of Toxicology, College of Medicine, National Taiwan University
Education
Ph.D.,1991 Institute of Pharmacology, College of Medicine, National Taiwan University, Taipei, Taiwan
M.S., 1986 Institute of Pharmacology, College of Medicine, National Taiwan University, Taipei, Taiwan
B.S., 1984 School of Pharmacy, College of Pharmacy, China Medical University, Taichung, Taiwan
Curriculum Vitae
Chiu HC, et al. A ubiquitous endocrine disruptor tributyltin induces muscle wasting and retards muscle regeneration. J Cachexia Sarcopenia Muscle. 2022 Nov 16. Epub ahead of print.
Lin CY, et al. Therapeutic ultrasound halts progression of chronic kidney disease in vivo via the regulation of markers associated with renal epithelial-mesenchymal transition and senescence. Int J Mol Sci. 2022 Nov 2;23(21):13387.
Liu SH, et al. Fish Oil Enriched n-3 Polyunsaturated fatty acids improve ketogenic low-carbohydrate/high-fat diet-caused dyslipidemia, excessive fat accumulation, and weight control in rats. Nutrients. 2022 Apr 25;14(9):1796.
Chen HJ, et al. Adverse effects of acrolein, a ubiquitous environmental toxicant, on muscle regeneration and mass. J Cachexia Sarcopenia Muscle. 2019 Feb;10(1):165-176.
Huang KH, et al. Role of Calbindin-D28k in diabetes-associated advanced glycation end-products-induced renal proximal tubule cell injury. Cells. 2019 Jun 30;8(7):660.
羅怡卿
Lo, Yi-Ching
14:10 - 14:40
聯合研討會—生理與藥理學會代謝疾病
Drug Discovery and Metabolic Functions of G Protein-coupled Receptors
洪明秀
Ming-Shiu Hung
洪明秀 Ming-Shiu Hung
Investigator and Associate Director 研究員暨副所長
Current Position
Institute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Taiwan
Education
B.S. National Taiwan University, Taiwan
M.S. National Sun Yat-sen University, Taiwan
Ph.D. Rutgers University, New Jersey, USA
Curriculum Vitae
Hsiao, W.C., et al.Modulating the affinity and signaling bias of cannabinoid receptor 1 antagonists. Bioorg. Chem. 130:106236 (2023)
Yeh, T.K. et al.Discovery and development of a novel N-(3-bromophenyl)- {[(phenylcarba moyl)amino]methyl}-N-hydroxythiophene-2-carboximidamide indoleamine 2,3-dioxygenase inhibitor using knowledge-based drug design. Eur. J. Med. Chem. 229:114043, 2022.
Yeh, Y.N. et al. A structure-function approach identifies L-PGDS as a mediator responsible for glucocorticoid-induced leptin expression in adipocytes. Biochem. Pharmacol. 166: 203-211, 2019.
Chang, C.P., et al. Fluorine-18 isotope labeling for positron emission tomography imaging. Direct evidence for DBPR211 as a peripherally restricted CB1 inverse agonist. Bioorg. Med. Chem. 27: 216-223, 2019.
羅怡卿
Lo, Yi-Ching
14:40 - 14:50
Café Break
14:50 - 15:20
聯合研討會—生理與藥理學會代謝疾病
Role of FKBP51 on development of obesity-associated metabolic disorders
阮琪昌
Chi-Chang Juan
阮琪昌 Chi-Chang Juan
Professor 教授
Current Position
Institute of Physiology, College of Medicine, National Yang Ming Chiao Tung University
Education
Ph.D. in Physiology, National Yang-Ming University, Taipei, Taiwan, 1998.
M.S. in Physiology, National Yang-Ming University, Taipei, Taiwan, 1993.
B.S. in Biology, Tunghai University, Taichung, Taiwan, 1991.
Curriculum Vitae
Endothelin-1 induces lipolysis through activation of the GC/cGMP/Ca2+/ERK/CaMKIII pathway in 3T3-L1 adipocytes. Biochim Biophys Acta Mol Cell Biol Lipids. 1867: 159071, 2022.
Nitric oxide mobilizes intracellular Zn2+ via the GC/cGMP/PKG signaling pathway and stimulates adipocyte differentiation. Int J Mol Sci. 23: 5488, 202
Increased regulated on activation, normal T-cell expressed and secreted levels and cysteine-cysteine chemokine receptor 5 upregulation in omental adipose tissue and peripheral blood mononuclear cells are associated with testosterone level and insulin resistance in polycystic ovary syndrome. Fertil Steril. 116: 1139, 2021.
Curcumin attenuates adipogenesis by inducing preadipocyte apoptosis and inhibiting adipocyte differentiation. Nutrients. 11: 2307, 2019.
李宗玄
Tzong-Shyuan Lee
15:20 - 15:50
聯合研討會—生理與藥理學會代謝疾病
New target in the treatment of obesity – associated metabolic syndrome and type 2 diabetes: The CCR5-mediated signaling
謝博軒
Po-Shiuan Hsieh
謝博軒 Po-Shiuan Hsieh
Professor 教授
Current Position
Department of Physiology and Biophysics, National Defense Medical Center, Taipei, Taiwan
Education
1982-89 M.D. (Medical Degree) National Defense Medical Center (NDMC), Taipei, Taiwan
1994-99 Ph.D. Department of Molecular Physiology and Biophysics, Vanderbilt University Medical School, USA
Curriculum Vitae
1. Chan, Pei-Chi, Chieh-Hua Lu, Hung-Che Chien, Yu-Feng Tian, and Po-Shiuan Hsieh*. (2022, Nov). Adipose Tissue-Derived CCL5 Enhances Local ProInflammatory Monocytic MDSCs Accumulation and Inflammation via CCR5 Receptor in High-Fat Diet-Fed Mice. International Journal of Molecular Sciences , 23, 22: 14226.
2. Chan, Pei-Chi, and Po-Shiuan Hsieh* (2022, Aug). The Role and Regulatory Mechanism of Brown Adipose Tissue Activation in Diet-Induced Thermogenesis in Health and Diseases . International Journal of Molecular Sciences, 23,16: 9448.
4. Pei-Chi Chan, Po-Shiuan Hsieh* (2021, Dec). The chemokine systems at the crossroads of inflammation and energy metabolism in the development of obesity. International Journal of Molecular Science, 2021; 22(24):13528.
5. Pei-Chi Chan, Min-Tser Liao, Chieh-Hua Lu, Yu-Feng Tian, Po-Shiuan Hsieh* (2021, Jan). Targeting inhibition of CCR5 on improving obesity-associated insulin resistance and impairment of pancreatic insulin secretion in high fat-fed rodent models. European Journal of Pharmacology, 891, 2021, 173703.
