Cancer assassins: fine-tuning the killers inside us
Gillian Griffiths
Gillian Griffiths
Current Position
Education
2015– present Journal of Cell Science
2005–2015 Journal of Cell Biology
2010– present BMC Biology
2008– present Current Opinions in Cell Biology
2008–2013 Editor, Traffic
Curriculum Vitae
Complete Publication List
ORCID 0000-0003-0434-5842
Lisci M and Griffiths GM
Arming a killer: mitochondrial regulation of CD8+ T cell cytotoxicity Trends in Cell Biology (2022) S0962-8924
PMID: 35753961
Lisci M, Barton PR, Randzavola LO, Ma CY, Marchingo J, Cantrell DA, Paupe V, Prudent J, Stinchcombe
JC, Griffiths GM
Mitochondrial translation is required for sustained killing by cytotoxic T cells Science (2021) 374(6565): eabe9977
PMID: 34648346
Richard AC, Frazer GL, Ma CY, Griffiths GM
Staggered starts in the race to T cell activation Trends in Immunology (2021) 42:994-1008
PMID: 34649777
Frazer G, Gawden-Bone C, Dieckmann N, Asano Y, Griffiths GM
Signal strength controls the rate of polarization within CTLs during killing J Cell Biol (2021) 220 (10): e202104093.
PMID: 34292303
Douanne T, Stinchcombe JC, Griffiths GM
Teasing out function from morphology: Similarities between primary cilia and immune synapses. J Cell Biol. 2021 220(6): e202102089. doi: 10.1083/jcb.202102089.
PMID: 33956049
Douanne, T and Griffiths GM
Cytoskeletal control of the secretory immune synapse Current Opinions in Cell Biology 71:87-94 (2021)
Griscelli Syndrome Type 2 Sine Albinism: Unraveling Differential RAB27A Effector Engagement.
Ohishi Y, Ammann S, Ziaee V, Strege K, Groß M, Amos CV, Shahrooei M, Ashournia P, Razaghian A, Griffiths
GM, Ehl S, Fukuda M, Parvaneh N. Front Immunol. 2020 11:612977. doi: 10.3389/fimmu.2020.612977.
PMID: 33362801
A new direction for Traffic.
Marks MS, Parton RG, Schroer TA, Tooze SA, Brodsky FM, Marsh M, Schmid SL, Griffiths GM, Stevens TH,
van Meer G. Traffic. 2020 21:724. doi: 10.1111/tra.12763.
PMID: 33190364
司徒惠康
Huey-Kang Sytwu
10:45 - 11:00
致德堂
大會開幕式
11:00 - 12:00
大會特別演講致德堂
Glucose metabolism and its signaling in cancer and immune regulation
林慧觀
Hui-Kuan Lin
林慧觀 Hui-Kuan Lin
Director of Prostate Cancer Center
Current Position
Department of Cancer Biology
Wake Forest University School of Medicine
Education
National Taiwan University, Taipei, Taiwan, Taiwan, BS, 1993, Pharmacy
National Taiwan University, Taipei, Taiwan, Taiwan, MS, 1995, Pharmacology
University of Rochester, Rochester, NY, PHD, 2002, Pathology (Cancer Biology)
Curriculum Vitae
Zhang, W., Wang, G., Xu, ZG., Tu, F., Dai, J., Chang, Y., Chen, Y., Lu, Y., Zeng, H., Cai, Z., Han, F., Xu, C., Jin, G., Sun, L., Pan, BS., Lai, SW., Hsu, CC., Xu, J., Chen, Z., Li, HY., Seth P., Hu, J., Zhang, X., Li, H., Lin, HK. Lactate is a natural suppressor of RLR signaling by targeting MAVS. Cell. 2019 Jun 27;178(1):176-189.e15. doi: 10.1016/j.cell.2019.05.003. Epub 2019 May 30.
Wang G, Long J, Gao Y, Zhang. W, HanF, XuC, SunL, YangSC, Lan J, HouZ, CaiZ, Jin G, Hsu CC, Wang YH, Hu J, Chen TY, Li H, Lee MG, Lin HK.SETDB1-mediated methylation of Akt promotes its K63-linked ubiquitination and activation leading to tumorigenesis. Nat. Cell Biol. 2019 Feb;21(2):214-225.
Chan CH, Morrow JK, Li CF, Gao Y, Jin G, Moten A, Stagg LJ, Ladbury JE, Cai Z, Xu D, Logothetis CJ, Hung MC, Zhang S, Lin HK. Pharmacological Inactivation of Skp2 SCF Ubiquitin Ligase Restricts Cancer Stem Cell Traits and Cancer Progression. Cell 154(3):556-68, 8/2013.
Chan CH, Li CF, Yang WL, Gao Y, Lee SW, Feng Z, Huang HY, Tsai KK, Flores LG, Shao Y, Hazle JD, Yu D, Wei W, Sarbassov D, Hung MC, Nakayama KI, Lin HK. The Skp2-SCF E3 Ligase Regulates Akt Ubiquitination, Glycolysis, Herceptin Sensitivity, and Tumorigenesis. Cell 149(5):1098-111, 5/2012.
Yang WL, Wang J, Chan CH, Lee SW, Campos AD, Lamothe B, Hur L, Grabiner BC, Lin X, Darnay BG, Lin HK. The E3 ligase TRAF6 regulates Akt ubiquitination and activation. Science 325(5944):1134-1138, 8/2009.
林琬琬
Wan-Wan Lin
12:00 - 14:00
科技新知研討會
午餐 科技新知研討會-伯森生物科技
陳美齡
Eileen Tan
陳美齡 Eileen Tan
Current Position
Education
Curriculum Vitae
Eileen currently works as the Scientific Support Specialist in Abcam Singapore, providing technical support to APAC life scientists to achieve their mission faster. She has 8 years of research and work experiences in life science companies and laboratories across Singapore, Malaysia, UK and Taiwan. Her PhD research focuses on the study of stress responses, particularly senescence and autophagy of cancer-associated fibroblasts (CAFs) in the tumour microenvironment (TME) of oral carcinoma.
楊鎧鍵
Kai-Chien Yang
13:00 - 14:20
陳烱霖轉譯醫學講座特別演講致德堂
Communication between cancer cells and immune cells during tumor progression
楊慕華
Muh-Hwa Yang
楊慕華 Muh-Hwa Yang
Chair professor of Institute of Clinical Medicine, Yang Ming Chiao Tung University
Current Position
Institute of Clinical Medicine, National Yang Ming Chiao Tung University
Education
M.D., National Yang-Ming University
Ph.D., National Yang-Ming University
Resident and clinical fellow of Division of Hematology-Oncology, Taipei Veterans General Hospital
Curriculum Vitae
Chen HY, Hsieh, CH, Lin PH, Chen YT, Hsu DS, Tai SK, Chu PY, Yang MH*. Snail regulated microRNA-21 suppresses NLRP3 inflammasome activity to enhance cisplatin resistance. J Immunother Cancer 2022;10:e004832.
Ou DL, Chen CW, Hsu CL, Chung CH, Feng ZR, Lee BS, Cheng AL, Yang MH*, Hsu C*. Regorafenib enhances antitumor immunity via inhibition of p38 kinase/Creb1/Klf4 axis in tumor-associated macrophages. J Immunother Cancer 2021;9:e001657.
Liao TT, Lin CC, Jiang JK, Yang SH, Teng HW, Yang MH*. Harnessing stemness and PD-L1 expression by AT-rich interaction domain-containing protein 3 in colorectal cancer. Theranostics 2020;10:6095-6112.
Li CF, Chen JY, Ho YH, Hsu WH, Wu, LC, Lan HY, Hsu DS, Tai SK, Chang YC*, Yang MH*. Snail-induced claudin-11 prompts collective migration for tumor progression. Nat Cell Biol 2019;21:251-262.
Hwang WL*, Lan HY, Cheng WY, Huang SC, Yang MH*. Tumor stem-Like cells-derived exosomal RNAs prime neutrophils for facilitating tumorigenesis of colon cancer. J Hematol Oncol 2019;12:10.
鄭子豪
TH Cheng
14:30 - 14:45
Café Break
14:30 - 16:40
致德堂
大會主題論文競賽
14:45 - 16:45
Oral presentation from selected abstracts
徐嘉琳
Chia-Lin Hsu
Time / 時間
Topic / 主題
Speaker / 講員
Moderator / 座長
Abstract / 摘要
09:30 - 10:10
Vaccine and immunity to SARS-CoV2 infection
Application of nanoparticle platforms for development of SARS-CoV-2 vaccines
陶秘華
Mi-Hua Tao
陶秘華 Mi-Hua Tao
Research Fellow and CEO, Institute of Biomedical Sciences/Biomedical Translation Research Center, Academia Sinica/中央研究院生物醫學研究所研究員/生醫轉譯中心執行長
Current Position
Institute of Biomedical Sciences/Biomedical Translation Research
Education
1979-1983 B.S. National Taiwan University, Taipei, Taiwan
1985-1986 Master, Microbiology&Immunology, Columbia University, New York, U.S.A.
1985-1990 Ph.D., Microbiology&Immunology, Columbia University, New York, U.S.A.
1990-1993 Postdoctoral fellow, Oncology,Stanford University, U.S.A.
Curriculum Vitae
Lee I. J., Y. H. Lan, P. Y. Wu, Y. W. Wu, T. H. Chen, Y. H. S. C. Tseng, T. J. Kuo, C. P. Sun, J. T. Jan, H. H. Ma, C. C. Liao, J. J. Liang, H. Y. Ko, C. S. Chang, W. C. Liu, Y. A. Ko, Y. H. Chen, Z. L. Sie, S. L. Tsung, Y. L. Lin, I. H. Wang and M. H. Tao*. A receptor-binding domain-based nanoparticle vaccine elicits durable neutralizing antibody responses against SARS-CoV-2 and variants of concern. Emerg Microbes Infect. 2023 Dec;12(1):2149353. doi: 10.1080/22221752022.2149353. PMID: 36395071 Free PMC article.
Lee, I. J., C. P. Sun, P. Y. Wu, Y. H. Lan, I. H. Wang, W. C. Liu, J.P. Yuan, Y. W. Chang,S. C. Tseng,S. I. Tsung,Y. C. Chou,M. Kumari,Y. S. Lin,H. F. Chen,T. Y. Chen,C. C. Lin,C. W. Chiu,C. H. Hsieh,C. Y. Chuang,C. M. Cheng,H. T. Lin,W. Y. Chen, F. F. Hsu, M. H. Hong, C. C. Liao, C. S. Chang, J. J. Liang, H. H. Ma, M. T. Chiang, H. N. Liao, H. Y. Ko, L. Y. Chen, Y. A. Ko, P.Y. Yu, T. J. Yang, P. C. Chiang, S. T. Hsu, Y. L. Lin, C. C. Lee, H. C. Wu, and M. H. Tao*. A booster dose of Delta × Omicron hybrid mRNA vaccine produced broadly neutralizing antibody against Omicron and other SARS-CoV-2 variants. J Biomed Sci. 2022 Jul 7;29(1):49. doi: 10.1186/s12929-022-00830-1. PMID: 35128033
Su, S. C., T. J. Yang, P. Y. Yu, K. H. Liang, W. Y. Chen, C. W. Yang, H. T. Ling, M. J. Wang, R. M. Lu, H. C. Tso, M. J. Chung, T. Y. Hsieh, Y. L. Chang, S. C. Lin, F. Y. Hsu, F. Y. Ke, Y. H. Wu, Y. C. Hwang, J. J. Liang, C. C. Liao, C. C. Ko, C. P. Sun, P. Y. Wu, Y. L. Lin*, M. H. Tao*, S. D. Hsu* & H. C. Wu*. (2021) Structure-guided antibody cocktail for prevention and treatment of COVID-19. PLoS Pathog. 2021 Oct 21;17(10):e1009704. doi: 10.1371/journal.ppat.1009704. eCollection 2021 Oct. PMID: 34673836
Sun, C. P., J. T. Jan, I. H. Wang, H. H. Ma, H. Y. Ko, P. Y. Wu, T. J. Kuo, H. N. Liao, Y. H. Lan, Z. L. Sie, Y. H. Chen, Y. A. Ko, C. C. Liao, L. Y. Chen, I. J. Lee, S. I. Tsung, Y. J. Lai, M. T. Chiang, J. J. Liang, W. C. Liu, J. R. Wang, J. P. Yuan, Y. S. Lin, Y. C. Tsai, S. L. Hsieh, C. W. Li, H. C. Wu, T. M. Ko, Y. L. Lin* & M. H. Tao*. (2021) Rapid generation of mouse model for emerging infectious disease with the case of severe COVID-19.PLoS Pathog. 2021 Aug 11;17(8):e1009758. doi: 10.1371/journal.ppat.1009758. eCollection 2021 Aug. PMID: 34379705.
Lien, C. E., Y. J. Lin, C. Chen, W. C. Lian, T. Y. Kuo, J. D. Campbell, P. Traquina, M. Y. Lin, L. T. Liu, Y. S. Chuang, H. Y. Ko, C. C. Liao, Y. H. Chen, J. T. Jan, H. H. Ma, C. P. Sun, Y. S. Lin, P. Y. Wu, Y. C, Wang, M. H. Tao* & Y. L. Lin*. (2021) CpG-adjuvanted stable prefusion SARS-CoV-2 spike protein protected hamsters from SARS-CoV-2 challenge. Sci Rep. 2021 Apr 22;11(1):8761. doi: 10.1038/s41598-021-88283-8. PMID: 33888840
謝世良
Hsieh, Shie-Liang
10:10 - 10:50
Vaccine and immunity to SARS-CoV2 infection
Anti-SARS-CoV-2 human antibodies
黃冠穎
Kuan-Ying A. Huang
黃冠穎 Kuan-Ying A. Huang
台大醫院 兒童感染科 主治醫師
Current Position
Department of Pediatrics, National Taiwan University Hospital
Graduate Institute of Immunology, National Taiwan University
Education
台灣大學 醫學系 學士
牛津大學 臨床醫學系 博士
Curriculum Vitae
Chen et al, A randomized controlled trial of heterologous ChAdOx1 nCoV-19 and recombinant subunit vaccine MVC-COV1901 against COVID-19. Nature Communications. 2022.
Huang et al, Structures and therapeutic potential of anti-RBD human monoclonal antibodies against SARS-CoV-2. Theranostics. 2022.
Huang KA, Structural basis for neutralization of enterovirus. Current Opinion in Virology. 2021.
Huang et al, Breadth and function of antibody response to acute SARS-CoV-2 infection in humans. PLoS Pathogens. 2021.
Huang et al, Structural and functional analysis of protective antibodies targeting the threefold plateau of enterovirus 71. Nature Communications. 2020.
謝世良
Hsieh, Shie-Liang
10:50 - 11:10
Café Break
11:10 - 13:00
壁報論文競賽展示與競賽
13:00 - 14:00
午餐
14:00 - 14:30
Regulation of autoimmune disease
The innate immune checkpoint NLRP12 represses IFN signatures and attenuates the progression of lupus nephritis
陳斯婷
Szu-Ting, Chen
陳斯婷 Szu-Ting, Chen
Associate Professor/副教授
Current Position
Institute of Clinical Medicine, National Yang Ming Chiao Tung University
Education
1. Ph.D., Life Science (Immunology), National Yang-Ming University, Taiwan
2. MS., Life Science (Plant genetic engineering), National Taiwan University, Taiwan
3. BS., Agronomy, National Taiwan University, Taiwan
Curriculum Vitae
Yen-Po Tsao, Fang-Yu Tseng4 Chih-Wei Chao,Ming-Han Chen, Yi-Chen Yeh, Babamale Olarewaju Abdulkareem, Se-Yi Chen, Wen-Ting Chuang, Pei-Ching Chang, I-Chun Chen, Pin-Hsuan Wang, Chien-Sheng Wu, Chang-Youh Tsai, and Szu Ting Chen*. NLRP12 is an innate immune checkpoint for repressing IFN signatures and attenuating lupus nephritis progression. Journal of Clinical Investigation,134, (1), (2023) *corresponding author
Gut Paneth cells controls cholesterol homeostasis and microbiota-dependent steatosis
徐志文
Shui, Jr-Wen
徐志文 Shui, Jr-Wen
Associate Research Fellow
Current Position
Institute of Biomedical Sciences, Academia Sinica, Taiwan
Education
1995, MS in Immunology, National Taiwan University, Taiwan
2004, PhD in Immunology, Baylor College of Medicine, Houston, USA
Curriculum Vitae
GY Seo, D Takahashi, Q Wang, Z Mikulski, A Chen, TF Chou, P Marcovecchio, S McArdle, A Sethi, JW Shui, M Takahashi, CD Surh, H Cheroutre, and M Kronenberg. Epithelial HVEM maintains intraepithelial T cell survival and contributes to host protection. Science Immunology 7: eabm6931 (Jul 2022)
C Stienne, RV Slane, L Elmen, M Veny, S Huang, J Nguyen, E Chappell, MO Balmert, JW Shui, MA Hurchla, M Kronenberg, SN Peterson, KM Murphy, CF Ware, and JR Sedy. Btla signaling in conventional and regulatory lymphocytes coordinately tempers humoral immunity in the intestinal mucosa. Cell Reports 38:110533 (Mar 2022)
HY Chiang, HH Lu, JN Sudhakar, YW Chen, NS Shih, YT Weng, and JW Shui*. IL-22 initiates an IL-18-dependent epithelial response circuit to enforce intestinal host defense. Nature Communications 13:874 (Feb 2022)
JN Sudhakar, HH Lu, HY Chiang, CS Suen, MJ Hwang, SY Wu, CN Shen, YM Chang, FA Li, FT Liu, and
JW Shui*. Luminal Galectin-9-Lamp2 interaction promotes lysosome stabilization and facilitates autophagy to prevent pathogenesis in the pancreas and intestine. Nature Communications 11:4286 (Aug 2020)
