Centriole, Centrosome, and Cilium: How These Organelles are Built in Cells and Their Associated Diseases
Tang K. Tang
唐堂 Tang K. Tang
Vice President, Academician 副院長、院士
Institute of Biomedical Sciences, Academia Sinica
1974-1978 B.S. Dept. of Biology, Tunghai University, Taiwan
1981-1983 M.S. Dept. of Microbiology and Immunology
National Yang-Ming Medical College, Taiwan
1984-1988 M.Ph./Ph.D. Dept. of Human Genetics, Yale University, USA
An HL, Kuo HC, Tang TK (2022) Modeling human primary microcephaly with hiPSC-derived brain organoids carrying CPAP-E1235V disease-associated mutant protein. Front Cell Dev Biol. 10:830432.
Chang CH, Chen TY, Lu IL, Li RB, Tsai JJ, Lin PY, Tang TK (2021) CEP120-mediated KIAA0753 recruitment onto centrioles is required for timely neuronal differentiation and germinal zone exit in the developing cerebellum. Genes & Development. 35:1445–1460.
Wu CT, Chen HY, Tang TK (2018) Myosin-Va is required for preciliary vesicle transportation to the mother centriole during ciliogenesis. Nat. Cell Biol. 20, 175–185.
Chen HY, Wu CT, Tang CJC, Lin YN, Wang WJ, Tang TK (2017) Human microcephaly protein RTTN interacts with STIL and is required to build full-length centrioles. Nat. Commun. 2017, 8:247.
Lin YN, Wu CT, Lin YC, Hsu WB, Tang CJC, Chang CW, Tang TK (2013) CEP120 interacts with CPAP and positively regulates centriole elongation. J. Cell Biol. 202, 211-219.
10:45 - 11:00
11:00 - 12:00
Glucose metabolism and its signaling in cancer and immune regulation
林慧觀 Hui-Kuan Lin
Director of Prostate Cancer Center
Department of Cancer Biology
Wake Forest University School of Medicine
National Taiwan University, Taipei, Taiwan, Taiwan, BS, 1993, Pharmacy
National Taiwan University, Taipei, Taiwan, Taiwan, MS, 1995, Pharmacology
University of Rochester, Rochester, NY, PHD, 2002, Pathology (Cancer Biology)
Zhang, W., Wang, G., Xu, ZG., Tu, F., Dai, J., Chang, Y., Chen, Y., Lu, Y., Zeng, H., Cai, Z., Han, F., Xu, C., Jin, G., Sun, L., Pan, BS., Lai, SW., Hsu, CC., Xu, J., Chen, Z., Li, HY., Seth P., Hu, J., Zhang, X., Li, H., Lin, HK. Lactate is a natural suppressor of RLR signaling by targeting MAVS. Cell. 2019 Jun 27;178(1):176-189.e15. doi: 10.1016/j.cell.2019.05.003. Epub 2019 May 30.
Wang G, Long J, Gao Y, Zhang. W, HanF, XuC, SunL, YangSC, Lan J, HouZ, CaiZ, Jin G, Hsu CC, Wang YH, Hu J, Chen TY, Li H, Lee MG, Lin HK.SETDB1-mediated methylation of Akt promotes its K63-linked ubiquitination and activation leading to tumorigenesis. Nat. Cell Biol. 2019 Feb;21(2):214-225.
Chan CH, Morrow JK, Li CF, Gao Y, Jin G, Moten A, Stagg LJ, Ladbury JE, Cai Z, Xu D, Logothetis CJ, Hung MC, Zhang S, Lin HK. Pharmacological Inactivation of Skp2 SCF Ubiquitin Ligase Restricts Cancer Stem Cell Traits and Cancer Progression. Cell 154(3):556-68, 8/2013.
Chan CH, Li CF, Yang WL, Gao Y, Lee SW, Feng Z, Huang HY, Tsai KK, Flores LG, Shao Y, Hazle JD, Yu D, Wei W, Sarbassov D, Hung MC, Nakayama KI, Lin HK. The Skp2-SCF E3 Ligase Regulates Akt Ubiquitination, Glycolysis, Herceptin Sensitivity, and Tumorigenesis. Cell 149(5):1098-111, 5/2012.
Yang WL, Wang J, Chan CH, Lee SW, Campos AD, Lamothe B, Hur L, Grabiner BC, Lin X, Darnay BG, Lin HK. The E3 ligase TRAF6 regulates Akt ubiquitination and activation. Science 325(5944):1134-1138, 8/2009.
Communication between cancer cells and immune cells during tumor progression
楊慕華 Muh-Hwa Yang
Chair professor of Institute of Clinical Medicine, Yang Ming Chiao Tung University
Institute of Clinical Medicine, National Yang Ming Chiao Tung University
M.D., National Yang-Ming University
Ph.D., National Yang-Ming University
Resident and clinical fellow of Division of Hematology-Oncology, Taipei Veterans General Hospital
Chen HY, Hsieh, CH, Lin PH, Chen YT, Hsu DS, Tai SK, Chu PY, Yang MH*. Snail regulated microRNA-21 suppresses NLRP3 inflammasome activity to enhance cisplatin resistance. J Immunother Cancer 2022;10:e004832.
Ou DL, Chen CW, Hsu CL, Chung CH, Feng ZR, Lee BS, Cheng AL, Yang MH*, Hsu C*. Regorafenib enhances antitumor immunity via inhibition of p38 kinase/Creb1/Klf4 axis in tumor-associated macrophages. J Immunother Cancer 2021;9:e001657.
Liao TT, Lin CC, Jiang JK, Yang SH, Teng HW, Yang MH*. Harnessing stemness and PD-L1 expression by AT-rich interaction domain-containing protein 3 in colorectal cancer. Theranostics 2020;10:6095-6112.
Li CF, Chen JY, Ho YH, Hsu WH, Wu, LC, Lan HY, Hsu DS, Tai SK, Chang YC*, Yang MH*. Snail-induced claudin-11 prompts collective migration for tumor progression. Nat Cell Biol 2019;21:251-262.
Hwang WL*, Lan HY, Cheng WY, Huang SC, Yang MH*. Tumor stem-Like cells-derived exosomal RNAs prime neutrophils for facilitating tumorigenesis of colon cancer. J Hematol Oncol 2019;12:10.
14:30 - 16:40
14:40 - 14:50
14:50 - 15:20
Protein N-terminal Acetylation in Development and Disease
阮麗蓉 Li-Jung Juan
Professor and Research Fellow, Genomics Research Center, Academia Sinica 中央研究院基因體研究中心研究員
Genomics Research Center, Academia Sinica
• Ph.D. training with Jerry Workman, The Pennsylvania State University 美國賓州州立大學 (01/1992- 08/1996)
• Postdoctoral Fellow (06/1997-10/2000) and Assistant Investigator (10/2000-03/2006), National Health Research Institutes 國家衛生研究院, Taiwan ROC
Lee CC*, Shih YC, Kang ML, Chang YC, Chuang LM, Devaraj R, Juan LJ*, 2019, “Naa10p Inhibits Beige Adipocyte-Mediated Thermogenesis through N-alpha-acetylation of Pgc1alpha.”, Molecular Cell, 76(3), 500-515.e8.
Lee CC, Peng SH, Shen L, Lee CF, Du TH, Kang ML, Xu GL, Upadhyay AK, Cheng X, Yan YT, Zhang Y*, Juan LJ*, 2017, “The Role of N-alpha-acetyltransferase 10 Protein in DNA Methylation and Genomic Imprinting.”, Molecular Cell, 68(1), 89-103.e7.
Teng YC, Lee CF, Li YS, Chen YR, Hsiao PW, Chan MY, Lin FM, Huang HD, Chen YT, Jeng YM, Hsu CH, Yan Q, Tsai MD, Juan LJ*, 2013, “Histone demethylase RBP2 promotes lung tumorigenesis and cancer metastasis.”, Cancer Research, 73(15), 4711-21.
Lee CF, Ou DS, Lee SB, Chang LH, Lin RK, Li YS, Upadhyay AK, Cheng X, Wang YC, Hsu HS, Hsiao M, Wu CW*, Juan LJ*, 2010, “hNaa10p contributes to tumorigenesis by facilitating DNMT1-mediated tumor suppressor gene silencing.”, The Journal of Clinical Investigation, 120(8), 2920-30.
Tu S, Teng YC, Yuan C, Wu YT, Chan MY, Cheng AN, Lin PH, Juan LJ*, Tsai MD*, 2008, “The ARID domain of the H3K4 demethylase RBP2 binds to a DNA CCGCCC motif.”, Nature Structural & Molecular Biology, 15(4), 419-21.
15:20 - 15:50
Inflammation-induced macrophage lysyl oxidase in adipose stiffening and dysfunction in obesity
蔡曜聲 Yau-Sheng Tsai
Institute of Clinical Medicine, National Cheng Kung University, Tainan, Taiwan
2005-2006: Postdoctoral fellow, Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, USA
2000-2005: PhD, Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, USA
1994-1996: MS, Department of Biochemistry, National Cheng Kung University, Taiwan
YS Chang, SY Hou, SS Yu, SY Tsai, YY Chen, LJ Hsu, PJ Tsai, HK Lin, CH Lin*, and YS Tsai*. Postnatal dexamethasone therapy impairs brown adipose tissue thermogenesis and autophagy flux in neonatal rat pups. Theranostics. 2022 Jul 25;12(13):5803-5819.
CC Hsu#, YS Tsai#, HK Lin. UHRF1: a novel metabolic guardian restricting AMPK activity. Cell Research. 2022 Jan;32(1):3-4. (# equal contribution)
Liu CJ, Cheng CW, Tsai YS, Huang HS. Crosstalk between Renal and Vascular A Huang, YS Lin, LZ Kao, YW Chiou, GH Lee, HH Lin, CH Wu, CS Chang, KT Lee, YY Hsueh, PJ Tsai, MJ Tang, YS Tsai*. Inflammation-induced macrophage lysyl oxidase in adipose stiffening and dysfunction in obesity. Clinical and Translational Medicine. 2021 Sep;11(9):e543.
Chen JY, Wu YP, Li CY, Jheng HF, Kao LZ, Yang CC, Leu SY, Lien IC, Weng WT, Tai HC, Chiou YW, Tang MJ, Tsai PJ, Tsai YS*. PPARγ activation improves the microenvironment of perivascular adipose tissue and attenuates aortic stiffening in obesity. J Biomed Sci. 2021 Mar 29;28(1):22.
CC Yang, DC Lin, YN Chang, CH Wu, CS Chang, KT Lee, PJ Tsai, and YS Tsai*. Inhibitory effect of PPARγ on NLRP3 inflammasome activation. Theranostics. 2021 Jan 1;11(5):2424-2441.
15:50 - 16:20
Metabolic Reprogramming in Health and Disease
WANG WEN CHING
王雯靜 WANG WEN CHING
Distinguished Professor 特聘教授
D epartment of Life Science & I nstitute of Molecular and
Cellular Biology, National Tsing Hua University
Ph.D. in Chemistry Department, California Institute of Technology,
Pasadena, CA, U.S.A. (Dr. P. J. Bjorkman s lab)
1985 M.S. in Chemistry Department, University of California, Santa Barbara, CA,U.S.A.
1983B.S. in Agricultural Chemistry, National Taiwan University, Taiwan
Liu J S, Fang W., Yang SM, Wu M., Chen TJ, Chen CM, Lin TY, Liu KL, Wu CM, Chen YC, Chuu CP, Wang LY, Hsieh HP, Kung HJ, and Wang WC* (2022) Natural product myricetin is a pan-KDM4 inhibitor which with poly lactic-co-glycolic acid formulation effectively targets castration-resistant prostate cancer. J. Biomed. Sci. 29, 29
Wu MJ, Chen CJ, Lin TY, Liu YY, Tseng LL, Cheng ML, Chuu CP, Tsai HK, Kuo WL, Kung HJ*, and Wang WC* (2021). Targeting KDM4B that coactivates c-Myc-regulated metabolism to suppress tumor growth in castration-resistant prostate cancer. Theranostics, 11(16), 7779-7796. doi:10.7150/thno.58729 (IF: 11.556)
Tseng LL†, Cheng HH†, Yeh TS†, Huang SC, Syu YY, Chuu CP, Yuh CH, Kung HJ, Wang WC*(2020). Targeting the histone demethylase PHF8-mediated PKCα-Src-PTEN axis in HER2-negative gastric cancer. Proc Natl Acad Sci USA, 117(40), 24859-24866. Epub, 23 September 2020 (IF: 11.205)
Chen TJ, Wang HJ, Liu JH, Cheng HH, Hsu SC, Wu MC, Lu CH, Wu YF, Wu JW, Liu YY, Kung HJ*, and Wang WC* (2019). Mutations in the PKM2 exon-10 region are associated with reduced allostery and increased nuclear translocation. Commun. Biol. 2, 2019: 105 doi: 10.1038/s42003-019-0343-4 (IF: 6.268)
Wang HJ, Hsieh YJ, Cheng WC, Lin CP, Lin YS, Yang SF, Chen CC, Izumiya Y, Yu JS, Kung HJ*, and Wang WC* (2014). JMJD5 regulates PKM2 nuclear translocation and reprograms HIF-1a-mediated glucose metabolism. Proc. Natl. Acad. Sci. USA 111, 279−284.
16:20 - 16:50
Developing novel therapeutics for nonalcoholic fatty liver disease via enhancing CISD2 prolongevity gene
蔡亭芬 Ting-Fen Tsai
Distinguished Professor 特聘教授
Department of Life Sciences and Institute of Genome Sciences, National Yang Ming Chiao Tung University, Taipei, Taiwan.
Graduate Institute of Microbiology and Immunology, National Yang-Ming University, Taipei, Taiwan Ph.D. 1989-1995 Molecular Biology
Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA Postdoc 1995-1999 Genetics and Inherited Diseases
Howard Hughes Medical Institute, Baylor College of Medicine, Houston, TX, USA Associate 1995-1999 Genetics and Inherited Diseases
Yeh CH, Shen ZQ, Wang TW, Kao CH, Teng YC, Yeh TK, Lu CK, Tsai TF*. Hesperetin promotes longevity and delays aging via activation of Cisd2 in naturally aged mice. J Biomed Sci 29, 53 (2022 July; IF 12.771).
Huang YL, Shen ZQ, Huang CH, Lin CH, Tsai TF*. Cisd2 slows down liver aging and attenuates age-related metabolic dysfunction. Aging Cell 20(12): e13523 (2021 Dec; IF 11.005).
Yeh CH*, Shen ZQ, Hsiung SY, Wu CY, Wu PC, Teng YC, Fang SW, Chen CF, Tzeng TY, Yan YT, Kao LS, Kao CH, Tsai TF*. Cisd2 is essential to delaying cardiac aging and to maintaining heart functions. PLoS Biology 17(10): e3000508 (2019 Oct; IF 9.593).
Huang YL, Shen ZQ, Wu CY, Teng YC, Liao CC, Kao CH, Chen LK, Lin CH*, Tsai TF*. Comparative proteomic profiling reveals a role of Cisd2 in skeletal muscle aging. Aging Cell 17: e12705 (2018 Feb; IF 11.005).
Shen ZQ, Chen YF, Chen JR, Jou YS, Wu PC, Kao CH, Wang CH, Huang YL, Huang TS, Shyu YC, Tsai SF, Kao LS, Tsai TF*. CISD2 haploinsufficiency disrupts calcium homeostasis, causes nonalcoholic fatty liver disease and promotes hepatocellular carcinoma. Cell Reports 21: 2198-2211 (2017 Nov; IF 9.995).
Time / 時間
Topic / 主題
Speaker / 講員
Moderator / 座長
Abstract / 摘要
09:00 - 12:30
11:30 - 12:30
12:00 - 13:30
14:10 - 15:10
龔行健 Hsing-Jien Kung
Chair Professor, Taipei Medical University, Taipei, Taiwan
Taipei Medical University
National Taiwan University, BS 65-69 Chemistry
California Institute of Technology, PhD 70-75 Chemistry
University of California, San Francisco, Postdoc, 76-78 Molecular virology
Jiang N, Xie B, Xiao W, Fan M, Xu S, Duan Y, Hamsafar Y, Evans AC, Huang J, Zhou W, Lin X, Ye N, Wanggou S, Chen W, Jing D, Fragoso RC, Dugger BN, Wilson PF, Coleman MA, Xia S, Li X, Sun LQ, Monjazeb AM, Wang A, Murphy WJ, Kung HJ, Lam KS, Chen HW, Li JJ. Fatty acid oxidation fuels glioblastoma radioresistance with CD47-mediated immune evasion Nat Commun. Mar 21;13(1):1511. (2022)
Chen CL, Hsu SC, Chung TY, Chu CY, Wang HJ, Hsiao PW, Yeh SD, Ann DK, Yen Y, Kung HJ. Arginine is an epigenetic regulator targeting TEAD4 to modulate OXPHOS in prostate cancer cells. Nat Commun (2021) 12:2398
Tseng LL, Cheng HH, Yeh TS, Huang SC, Syu YY, Chuu CP, Yuh CH, Kung HJ, Wang WC. Targeting the histone demethylase PHF8-mediated PKCα-Src-PTEN axis in HER2-negative gastric cancer. Proc Natl Acad Sci U S A. (2020) 117:24859
Yang CP, Yang WS, Wong YH, Wang KH, Teng YC, Chang MH, Liao KH, Nian FS, Chao CC, Tsai JW, Hwang WL, Lin MW, Tzeng TY, Wang PN, Campbell M, Chen LK, Tsai TF, Chang PC, Kung HJ. Muscle atrophy-related myotube-derived exosomal microRNA in neuronal dysfunction: Targeting both coding and long noncoding RNAs. Aging Cell. 19(5):e13107. (2020)