Professional and Research Experience:
2019- Distinguished Chair Professor, Institute for Translation Research in Biomedicine (ITRBM), Chang Gung Memorial Hospital, Kaohsiung, Taiwan
2011-19 Chair Professor, ITRBM, Chang Gung Memorial Hospital, Kaohsiung, Taiwan
2012-17 Director, Department of Medical Research, Chang Gung Memorial Hospital, Kaohsiung, Taiwan
2007-11 Head, Division of Basic Medical Research, Veterans General Hospital, Kaohsiung, Taiwan
1998-11 Senior Principal Investigator, 1996-98 Senior Principal Investigator, 1990-96 Principal Investigator, Department of Medical Research, Veterans General Hospital, Taipei, Taiwan
Major Honors:
2002-05 Convener, Physiology Study Section, National Science Council, Taiwan
2003- Associate Editor, Journal of Biomedical Sciences
2011-15 President, 2005-11 Vice-President, Federation of Asian and Oceanian Physiological Sciences
2007-11 President, Chinese Physiological Society
2017-21 President, 2013-17 Vice-President, International Union of Physiological Sciences
Major Awards:
2000 Outstanding Research Award, Taiwan Pharmacological Society
2000-12 Outstanding Research Award, Executive Yuan, Taiwan
2001 S.C. Wang Outstanding Research Award in Neuroscience, Taiwan
2004-15 Outstanding Research Award, National Science Council, Taiwan
2019 Life-time Achievement Award, Federation of Asian and Oceanian Physiological Societies
Selected Publications: 5 representative papers from 215 publications
Chan SHH, Wang LL, Chang KF, Ou CC, Chan JYH. Altered temporal profile of heat shock factor 1 phosphorylation and heat shock protein 70 expression induced by heat shock in nucleus tractus solitarii of spontaneously hypertensive rats. Circulation, 2003;107:339-345.
Chan SHH, Wu CWJ, Chang AYW, Hsu KS, Chan JYH. Transcriptional upregulation of brain-derived neurotrophic factor in rostral ventrolateral medulla by angiotensin II: Significance in superoxide homeostasis and neural regulation of arterial pressure. Circulation Research, 2010;107:1127-1139.
Chan SHH, Chan JYH. Brain stem NOS and ROS in neural mechanisms of hypertension. Antioxidants and Redox Signaling, 2014;20:146-163.
Chan SHH, Chan JYH. Phosphodiesterase 2 as a therapeutic target for heart failure: is upregulation an option? Circulation Research, 2017;120:13-16.
Chan JYH, Chan SHH. Differential impacts of brain stem oxidative stress and nitrosative stress on sympathetic vasomotor tone. Pharmacology and Therapeutics, 2019;201: 20-136.
Professional and Research Experience:(Begin with the initial professional experience)
Professor, The University of Texas M.D. Anderson Cancer Center, TX, 09/94-02/17/19
Department Chair, Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, 3/2000−02/17/19
Ruth Legett Jones Distinguished Chair, The University of Texas MD Anderson Cancer Center, Houston, TX, 1/2003−02/17/19
Director, Center for Biological Pathways, The University of Texas MD Anderson Cancer Center, Houston, TX, 9/2008−02/17/19
Vice President for Basic Research, The University of Texas MD Anderson Cancer Center, Houston, TX, 3/2010−02/17/19
President (International), Society of Chinese Bioscientists in America, 2004−2005
Member, Board of Directors, China Medical University and Hospital Health System, Taiwan, 2004-01/2019.
Member, Review and Selection Committee in the Biopharmaceutical Science Category, Tang Prize, 2013- present.
Overseas Member, Scientific Advisory Board*, Institute of Molecular and Cellular Biology, A*STAR, Singapore, June 1, 2014-May 31, 2018. *Co-chaired by two Nobel Laureates: Drs. Randy Schekman and Thomas Sudhof.
Member, Cancer Research Advisory Board, Ministry of Health and Welfare of Taiwan, April 10, 2014 to December 31, 2017.
Member, Scientific Advisory Board, Life Sciences Institute, Zhejiang University, Hang Zhou, China, 2014- present.
Member, Advisory Committee, University of Macau, Macau, China, July 2015-2016
Member, Selection Committee, Pezcoller Foundation-AACR Award, 2016
Member, External Advisory Board, The University of Kansas Cancer Center, 2017-2019
President, China Medical University, Taichung, Taiwan 02/18/2019- present
Member, Advisory Board, Molecular Cell, Cell Press, 2020
Member, Presidential Science Prize Steering Committee總統科學獎委員會, 2020-2021
Member, National Taiwan University Advisory Committee, 2020-present
Member, Review Committee “Yu-Shan Scholars recruitment program”, Ministry of Education教育部「玉山學者」計畫【醫學】領域審議委員, 2020-present
Member, Academic Advisory Board (AAC), Institute of Molecular Biology, 01/01/2020-12/31/2022 & Biomedical Translation Research Center (BioTReC), National Biotechnology Research Park (NBRP), February 1, 2021 to October 17, 2022. Academia Sinica
Adjunct Researcher, Genomics Research Center, Academia Sinica, 2021
Awards and Honors:( up to five, Begin with the recent honor)
Selected as a candidate of the 2021 Highly Cited Researchers (Clarivate).
John P. McGovern Award for Outstanding Teaching, The University of Texas Health Science Center in Houston, 1990, 1993, 1999 and 2018
The University of Texas M. D. Anderson Cancer Center LeMaistre Outstanding Achievement Award, 2011.
Fellow, Section of Biological Sciences, American Association for the Advancement of Science, AAAS, 2010
Academician (Lifetime), Academia Sinica, Taiwan, 2002
Selected Publications: (up to five, Begin with the recent publication)
154 out of 582 peer-reviewed publications are published in journals which impact factor is 10 or above, of which 65 (48 CNS--Cell, Nature, Science series) serves as a corresponding (first or co-corresponding) author and 89 (62 CNS) as a co-author. 110 out of 154 are published in Cell, Nature, Science series. Life time h-index (Scopus)=127, Google Scholar 155
Jiang Z, Lim SO, Yan M, Hsu JL, Yao J, Wei Y, Chang SS, Yamaguchi H, Lee HH, Ke B, Hsu JM, Chan LC, Hortobagyi GN, Yang L, Lin C, Yu D, Hung MC. Tyro3 induces anti-PD-1/PD-L1 therapy resistance by limiting innate immunity and tumoral ferroptosis. J Clin Invest Apr 15;131(8):139434, 2021. doi: 10.1172/JCI139434.
Liu CX†, Zha Z†, Zhou C†, Chen Y, Xia W, Wang YN, Lee HH, Yin Y, Yan M. Chang CW, Qiu Y, Li H, Li CW, Hsu JM, Hsu JL, Wang SC, Ren N*, Hung MC*. Ribonuclease 7-driven activation of ROS1 is a new potential therapeutic target in hepatocellular carcinoma. J of Hepatology Apr 74(4):907-918, 2021. † Equal contribution; *Co-corresponding authors.
Hou J, Zhao R, Xia W, Chang CW, You Y, Hsu JM, Nie L, Chen Y, Wang YC, Liu C, Wang WJ, Wu Y, Ke B, Hsu JH, Huang K, Ye Z, Yang Y, Xia X, Li Y, Li CW, Shao B, Tainer JA, Hung MC. PD-L1-mediated Gasdermin C expression switches apoptosis to pyroptosis in cancer cells and facilitates tumor necrosis. Nature Cell Biology, Oct;22(10):1264-1275 (Sept 14 Epub online) 2020.
#*Xu D, #Wang Z, Xia Y, Shao F, Xia W, Wei Y, Li X, Qian X, Lee JH, Du L, Zheng Y, Lv G, Leu JS, Wang H, Xing D, Liang T, *Hung MC, *Lu Z. The gluconeogenic enzyme PCK1phosphorylates INSIG1/2 for lipogenesis. Nature 580(7804):530-535 (Epub April 8) 2020. #equal contribution *co-corresponding authors.
Lee HH, Wang YN, Xia W, Chen CH, Rau KM, Ye L, Chou CK, Wei Y, Wang SC, Yan M, Tu CY, Hsia TC, Chiang SF, Chao KSC, Wistuba II, Hsu JL, Hortobagyi GN, Hung MC. Removal of N-linked glycosylation enhances PD-L1 detection and predicts anti-PD-1/PD-L1 therapeutic efficacy. Cancer Cell 36(2):168-178, (epub online July 18) 2019.
Professional and Research Experience:
1994. ~ 1997. : Postdoctoral Researcher, Oxford University Laboratory of Physiology
1997 ~ 2008 : Lecturer, Assistant Professor, Associate Professor
2007 ~ 2008 : Visiting Scholar of UCSD
2008 ~ Present : Professor
Awards and Honors:
Selected Publications:
Pham DD, Lee YS, Chi S, CH Leem, The mean of fasting, 1-h, and 2-h plasma glucose levels is superior to each separate index in predicting diabetes, Diabetes Res. Clin. Prac. 2021
YK Jeon, JB Youm, K Ha, JH Woo, HY Yoo, CH Leem, SH Lee, SJ Kim Teaching cardiac excitation-contraction coupling using a mathematical computer simulation model of human ventricular myocytes Adv. in Physiol. Edu. 44 (3), 323 – 333 2020
M Hwang, CH Lim, CH Leem, EB Shim In silico models for evaluating proarrhythmic risk of drugs APL bioengineering 4 (2), 3 2020
DD Pham, JH Lee, KH Hong, YJ Jung, SJ Kim, CH Leem Seasonal effects on resting energy expenditure are dependent on age and percent body fat Clinical Nutrition 39 (4), 1276-1283
Professional and Research Experience:
1988-1989 Intern, National Taiwan University Hospital, Taipei, Taiwan
1989-1991 Medical Officer, Chinese Air Forces, Taiwan (mandatory military service)
1997-1999 Instructor of Neuroanatomy at Yale University School of Medicine, New Haven, CT
2001-2007 Assistant Professor, Division of Developmental Biology, Department of Pediatrics,Cincinnati Children's Hospital Medical Center, Cincinnati, OH
2007-2012 Associate Professor (tenured), Division of Developmental Biology and Neurology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH
2012-2017 Associate Professor (tenure-track 2012-2015; tenured 2015-2017), Department of Pediatrics, Division of Neurology, Emory University School of Medicine, Atlanta, GA
2014-2017 Director of Research, Division of Neurology, Department of Pediatrics, Emory University School of Medicine, Atlanta, GA
2018-Present Professor, Department of Neuroscience, University of Virginia School of Medicine, Charlottesville, VA
Selected Publications:
http://www.ncbi.nlm.nih.gov/pubmed/?term=Kuan+Rakic+P+or+Chia-Yi+Kuan
Professional and Research Experience:
2000 – 2020
Program Director
Postdoctoral Training Program in Clinical Chemistry, Laboratory Medicine and Pathobiology, University of Toronto
2013 – 2018
Chair
Communications and Publications Division, International Federation of Clinical Chemistry and Laboratory Medicine (IFCC)
1998 – 2002
Associate Scientist
Structural Biology & Biochemistry/Cardiovascular Diseases, Research Institute, the Hospital for Sick Children
1998 – 2001
Associate Professor
Laboratory Medicine and Pathobiology, University of Toronto
1995
Visiting Professor
Department of Clinical Biochemistry, University of Gothenburg, Sweden
1994 – 1998
Program Director
Graduate and Postdoctoral Training Program in Clinical Chemistry, Department of Chemistry and Biochemistry, University of Windsor
1993 – 1998
Adjunct Associate Professor
Pathology, School of Medicine, Wayne State University
1992 – 1998
Associate Professor (Tenured)
Chemistry and Biochemistry, University of Windsor – Tenure awarded in 1992
1998 – 1992
Assistant Professor
Chemistry and Biochemistry, University of Windsor
Awards and Honors:
Lifetime Achievement Award, Faculty of Medicine, University of Ottawa.
Richard G. Hegele Award for Excellence in Research and Innovation
AACC Norman P. Kubasik Award
AACC Academy Outstanding Research Award
Hungarian Society of Laboratory Medicine Award
Selected Publications:
1. Bohn MK, Yousef P, Steele S, Sepiashvili L, Adeli K. Multi-Inflammatory Syndrome in Children: A View into Immune Pathogenesis from a Laboratory Perspective. J Appl Lab Med. Epub 2021 Aug 31. doi:10.1093/jalm/jfab114. PubMed PMID: 34463724.
2. Wilson S, Bohn MK, Adeli K. POCT: An Inherently Ideal Tool in Pediatric Laboratory Medicine. EJIFCC. 2021 Jun 29;32(2):145-157. PubMed PMID: 34421483.
3. Wilson S, Bohn MK, Hall A, Higgins V, Abdelhaleem M, Adeli K. Continuous reference curves for common hematology markers in the CALIPER cohort of healthy children and adolescents on the Sysmex XN-3000 system. Int J Lab Hematol. Epub 2021 Aug 1. doi: 10.1111/ijlh.13670. PubMed PMID: 34333858.
4. Ghazizadeh H, Kathryn Bohn M, Yaghooti-Khorasani M, Kamel Khodabandeh A, Zare-Feyzabadi R, Timar A, Mohammadi-Bajgiran M, Oladi MR, Rohban M, Esmaily H, Ferns GA, Adeli K, Ghayour-Mobarhan M. Age- and sex-specific reference intervals for superoxide dismutase enzyme and several minerals in a healthy adult cohort. J Clin Lab Anal. 2021 Sep;35(9):e23897. doi: 10.1002/jcla.23897. PubMed PMID:34273186.
5. Bohn MK, Wilson S, Hall A, Adeli K. Pediatric reference interval verification for endocrine and fertility hormone assays on the Abbott Alinity system. Clin Chem Lab Med. 2021 Jun 30;59(10):1680-1687. doi:10.1515/cclm-2021-0337. PubMed PMID: 34187103.
Professional and Research Experience:
Post-doctoral training including residency/fellowship:
11/1992-11/1995
Resident in Pediatrics, Assistance Publique-Hôpitaux de Paris, France, EU
11/1995-09/1999
Clinical and Research Fellow, Pediatric Immunology and Hematology (Heads: Claude Griscelli and Alain Fischer), Necker Hospital for Sick Children and School of Medicine, Assistance Publique-Hôpitaux de Paris, Paris Descartes University, France, EU
Academic positions:
11/1995-09/1999
Research Fellow, Laboratory of Primary Immunodeficiencies (Head: A. Fischer), Necker Hospital for Sick Children and School of Medicine, Paris Descartes University, Paris, France, EU
09/1999-09/2008
Professor of Pediatric Hematology, Pediatric Immunology and Hematology Unit (Head: A. Fischer), Necker Hospital for Sick Children and School of Medicine, Paris Descartes University, Paris, France, EU
09/2000-09/2008
Head of Laboratory (with Laurent Abel), Laboratory of Human Genetics of Infectious Diseases, Necker Hospital for Sick Children and School of Medicine, Paris Descartes University, Paris, France, EU
09/2008-
Professor, The Rockefeller University, New York, USA
09/2008-
Head of Laboratory, St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, USA
09/2008-
Professor, University of Paris, Paris, France, EU
Head of Laboratory (with Laurent Abel), Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Imagine Institute, INSERM and University of Paris, France, EU
02/2014-
Investigator, Howard Hughes Medical Institute, New York, USA
12/2020-
Levy Family Professor, The Rockefeller University, New York, USA
Awards and Honors:
1992 Jean-Marie Dubert Prize for PhD Thesis in Immunology, Universités de Paris, France, EU
1994 Médaille d´Or de l´Internat en Médecine des hôpitaux de Paris, France, EU
1995 Pierre Robin Prize for MD Thesis, Chancellerie des Universités de Paris, France, EU
2000-2008 Junior Member, Institut Universitaire de France, France, EU
2001 Laureate, Schlumberger Foundation for Education and Research, France, EU
2003-2019 Member, Inborn Errors of Immunity Committee, International Union of Immunological Societies
2004 International Lucien Dautrebande Prize (Medicine), Royal Academy of Medicine, Belgium, EU
2005- Member, European Molecular Biology Organization
2005 Jacques Oudin Prize, Société Française d’Immunologie, France, EU
2005-2008 International Scholar, Howard Hughes Medical Institute
2006-2010 President, European Society for Primary Immunodeficiencies
2008 Richard Lounsbery Award, French Academy of Sciences, National Academy of Sciences USA
2008- Foreign Associate, American Society for Clinical Investigation
2008 AGF-Institut de France Prize, AGF Foundation and Institut de France, France, EU
2009 Doctor Honoris Causa, University of Zürich, Switzerland
2009 Oswald Avery Award, Infectious Diseases Society of America
2009- Member, The Practitioners' Society of New York
2010 E. Mead Johnson Award for Research in Pediatrics, Society for Pediatric Research
2010 Doctor Honoris Causa, University of Debrecen, Hungary
2011 InBev-Baillet Latour Health Prize, Immunology and Infectious Diseases, Belgium, EU
2012 Ilse and Helmut Wachter Foundation Award, Innsbruck Medical University, Austria, EU
2012 Seymour and Vivian Milstein Award, International Cytokine & Interferon Society
2014 Norman J. Siegel New Member Outstanding Science Award, American Pediatric Society
2014 Presidential Award, Clinical Immunology Society
2014 Robert Koch Prize, Germany, EU
2014 Member Honoris Causa, Scandinavian Society for Immunology
2014 Sanofi-Institut Pasteur International Mid-Career Award, France, EU
2015-2022 President, Henry Kunkel Society
2015- Foreign Associate, National Academy of Sciences, USA
2015- International Member, National Academy of Medicine, USA
2016 Stanley J. Korsmeyer Award, American Society for Clinical Investigation
2016 Grand Prix, Institut National de la Santé et de le Recherche Médicale, France, EU
2017 Steinman Award for Human Immunology Research, American Association of Immunologists
2018 Distinguished Service Award, Clinical Immunology Society
2018 Honorary Skou Professor, Aarhus University, Denmark, EU
2019 Grand Prix Claude Bernard, Paris, France, EU
2019 Thomas A. Waldmann Award for Excellence in Human Immunology, Foundation for Primary Immunodeficiency Diseases
2019 Honorary Member, Interurban Clinical Club
2019 Boyle Scientific Achievement Award, Immune Deficiency Foundation
2020- Member, Association of American Physicians
2020- Chevalier de l’ordre de la Légion d’Honneur, France, EU
2021- Member, Royal Academy of Medicine, Belgium, EU
2021 Doctor JuanAbarca International Award of Medical Sciences, Spain, EU
2022 Doctor Honoris Causa, Katholieke Universiteit Leuven, Belgium, EU
Selected Publications:
Béziat, V. et al. Humans with inherited T cell CD28 deficiency are susceptible to skin papillomaviruses but are otherwise healthy. Cell 184, 3812–3828.e30 (2021).
Yang, R. et al. Human T-bet Governs Innate and Innate-like Adaptive IFN-γ Immunity against Mycobacteria. Cell 183, 1826–1847.e31 (2020).
Bastard, P. et al. Autoantibodies against type I IFNs in patients with life-threatening COVID-19. Science 370, eabd4585 (2020).
Zhang, Q. et al. Inborn errors of type I IFN immunity in patients with life-threatening COVID-19. Science 370, eabd4570 (2020).
Casanova, J.-L. et al. A Global Effort to Define the Human Genetics of Protective Immunity to SARS-CoV-2 Infection. Cell 181, 1194–1199 (2020).
Professional and Research Experience:
Institute of Pharmacology, NTU; Assistant professor, 2011-2016.
Institute of Pharmacology, NTU; Associate professor, 2016-present.
Awards and Honors:
台灣大學醫學院青杏獎 (2016)
台灣大學教學傑出獎 (2020)
Selected Publications:
Yang KC, Chuang KW, Yen WS, Lin SY, Chen HH, Chang SW, Lin YS, Wu WL, Tsao YP, Chen WP*, Chen SL (2019) Deficiency of nuclear receptor interaction protein leads to cardiomyopathy by disrupting sarcomere structure and mitochondrial respiration. J Mol Cell Cardiol 137: 9-24. (* Corresponding author)
Fan SM, Chang YT, Chen CL, Wang WH, Pan MK, Chen WP, Huang WY, Xu Z, Huang HE, Chen T, Plikus MV, Chen SK, Lin SJ. External light activates hair follicle stem cells through eyes via an ipRGC-SCN-sympathetic neural pathway. Proc Natl Acad Sci U S A. 2018;115(29):E6880-E6889.
Ho YS, Tsai WH, Lin FC, Huang WP, Lin LC, Wu SM, Liu YR and Chen WP*. Cardioprotective Actions of TGFbetaRI Inhibition Through Stimulating Autocrine/Paracrine of Survivin and Inhibiting Wnt in Cardiac Progenitors. Stem cells. 2016;34:445-55. (*corresponding author)
Chen WP*, Liu YH, Ho YJ and Wu SM. Pharmacological inhibition of TGFbeta receptor improves Nkx2.5 cardiomyoblast-mediated regeneration. Cardiovascular research. 2015;105:44-54. (*corresponding author)
Professional and Research Experience:
2010-2016
Director, Molecular Imaging Center, National Institute of Radiological Sciences, Chiba
1999-2010
Professor of Molecular Imaging
Director, Biomedical Imaging Research Center, University of Fukui, Fukui
1993-1999
Associate Professor
Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto
1983-1993
Assistant Professor, Radioisotopes Research Laboratory
Kyoto University Hospital, Kyoto
Awards and Honors:
The Japanese Society of Nuclear Medicine Award (1994)
The Best Paper Award for Annals of Nuclear Medicine (1996)
The Best Paper Award for Japanese Journal of Nuclear Medicine (1997)
The Best Paper Award for the Journal of Nuclear Cardiology (2000)
Academic activity
Society of Radiopharmaceutical Sciences (Past President)
Society for Molecular Imaging (merged to WMIS now) (Past-President)
World Molecular Imaging Society (Fellow)
Federation of Asian Societies for Molecular Imaging (Past-President)
Japanese Society for Molecular Imaging (Founding President)
Japanese Society of Nuclear Medicine (Past Council member)
Selected Publications:
245 peer reviewed papers.
Professional and Research Experience:
2018/08-2022/07 Distinguished Professor, National Chung Hsing University, Taichung, Taiwan
2014/02-present Distinguished Research Fellow, Department of Medical Research, Taichung Veterans General Hospital, Taichung, Taiwan
2014/02-present Professor, Institute of Biomedical Sciences, National Chung Hsing University,
Taichung, Taiwan
2011/02-2014/01 Associate Professor, Institute of Biomedical Sciences, National Chung Hsing University, Taichung, Taiwan
2009/08-2011/01 Assistant Professor, Institute of Biomedical Sciences, National Chung Hsing University, Taichung, Taiwan
2007/02-2009/07 Assistant Professor, Institute of Medical Technology, National Chung Hsing University, Taichung, Taiwan
2005/08-2007/01 Assistant Professor, School of Medical Laboratory and Biotechnology, Chung Shan Medical University, Taiwan
Awards and Honors:
2020/08-2022/07 Distinguished Professor, National Chung Hsing University, Taichung, Taiwan【中興大學特聘教授】
2018/08-2020/07 Distinguished Professor, National Chung Hsing University, Taichung, Taiwan【中興大學特聘教授】
2018 Outstanding Researcher, Department of Medical Research, Taichung Veterans General Hospital, Taichung, Taiwan【國軍退除役官兵輔導委員會台中榮總107年度研究發展―特優獎】
2016 Outstanding Researcher, Department of Medical Research, Taichung Veterans General Hospital, Taichung, Taiwan【國軍退除役官兵輔導委員會台中榮總105年度研究發展―特優獎】
2014 Outstanding Researcher, Department of Medical Research, Taichung Veterans General Hospital, Taichung, Taiwan【國軍退除役官兵輔導委員會台中榮總103年度研究發展―特優獎】
2014 "Excellent Laboratory of Genetic Medicine Education Promotion"【2014「基因醫學教育推廣優秀實驗室」】
2014 The 6th Asia-Pacific Bayer Chinese Diabetes Forum - ABCD Best Basic Research Award 【2014第六屆亞太拜耳華人糖尿病論壇―ABCD最佳基礎研究獎】
2014 Outstanding Researcher Young Scientist Award, National Chung Hsing University 【103年度「國立中興大學優秀年輕學者獎助計畫（懷璧獎）」生命科學組】
Selected Publications:
Aggravation of pulmonary fibrosis after knocking down the Aryl hydrocarbon receptor in the Insulin-like growth factor 1 receptor pathway. Wu SM, Tsai JJ, Pan HC, Jack L. Arbiser JL, Elia L, Sheu ML*. British Journal of Pharmacology. 2022 Jan 26.
Targeting histone deacetylase-3 blocked epithelial-mesenchymal plasticity and metastatic dissemination in gastric cancer. Sheng-Mao Wu SM, Jan YJ, Tsai SC, Hung-Chuan Pan HC, Shen CC, Cheng-Ning Yang CN, Lee SH, Shing-Hwa Liu SH, Shen LW, Chiu CS, Jack L. Arbiser JL, Meng M, Sheu ML*. Cell Biology and Toxicology. 2022 Jan 1.
Dual Regeneration of Muscle and Nerve by Intramuscular Infusion of Mitochondria in a Nerve Crush Injury Model. Sheu ML, Shen CC, Tsou HK, Yang MY, Su HL, Sheehan J, Chang MH, Chen HS, Pan HC. Neurosurgery. 2021 Jun 15;89(1):E49-E59.
Advanced glycation end products activated endothelial-to-mesenchymal transition in pancreatic islet endothelial cells and triggered islet fibrosis in diabetic mice. Tsai PS, Chiu CY, Sheu ML*, Yang CY, Lan KC, Liu SH*. Chemico-Biological Interactions 2021 Aug 25;345:109562.
Sheu WH, Lin KH, Wang JS, Lai DW, Lee WJ, Lin FY, Chen PH, Chen CH, Yeh HY, Wu SM, Shen CC, Lee MR, Liu SH, Sheu ML*. Therapeutic Potential of Tpl2 (Tumor Progression Locus 2) Inhibition on Diabetic Vasculopathy Through the Blockage of the Inflammasome Complex. Arteriosclerosis Thrombosis and Vascular Biology. 2021 Jan;41(1):e46-e62.
Huang KH, Guan SS, Lin WH, Wu CT, Sheu ML, Chiang CK, Liu SH. Role of Calbindin-D28k in Diabetes-Associated Advanced Glycation End-Products-Induced Renal Proximal Tubule Cell Injury. Cells. 2019 Jun 30;8(7):660
Chiu CS, Tsai CH, Hsieh MS , Tsai SC, Jan YJ, Lin WY, Lai DW, Wu SM, Hsing HY, Arbiser JL, Sheu ML*. Exploiting Honokiol-induced ER stress CHOP activation inhibits the growth and metastasis of melanoma by suppressing the MITF and β-catenin pathways. Cancer Letters. 2018 Nov 1;442:113-125
Lai DW, Lin KH, Sheu WH, Lee MR, Chen CY, Lee WJ, Hung YW, Shen CC, Chung TJ, Liu SH, Sheu ML*.Therapeutic Targeting Tumor Progression Locus-2 (TPL2)/Activating Transcription Factor-4 (ATF4)/Chemokine Stromal Cell-Derived Factor-α (SDF1α) Axis Suppresses Diabetic Retinopathy. Circulation Research 2017 Sep 1;121(6):e37-e52. 2018 【2018 selected Outstanding research paper award of TienTe Lee medication foundation第12屆永信李天德醫藥科技獎，研究生獲選-傑出論文獎】【2018 Outstanding research paper award of Jung-Yaw Lin academic education foundation研究生獲選-2017第14屆林榮耀教授學術教育基金會論文獎】
Wu SM, Lin WY, Shen CC, Pan HC, Keh-Bin W, Chen YC, Jan YJ, Lai DW, Tang SC, Tien HR, Chiu CS, Tsai TC, Lai YL, Sheu ML*. Melatonin set out to ER stress signaling thwarts epithelial mesenchymal transition and peritoneal dissemination via calpain-mediated C/EBPβ and NFκB cleavage. Journal of Pineal Research. 2016 Mar;60(2):142-54. 【2017 selected Outstanding research paper award of TienTe Lee medication foundation第12屆永信李天德醫藥科技獎，研究生獲選-傑出論文獎】【2018 Outstanding research paper award of Jung-Yaw Lin academic education foundation研究生獲選-2017第14屆林榮耀教授學術教育基金會論文獎】
Chiang CK, Wang CC, Lu TF, Huang KH, Sheu ML, Liu SH, Hung KY. Involvement of Endoplasmic Reticulum Stress, Autophagy, and Apoptosis in Advanced Glycation End Products-Induced Glomerular Mesangial Cell Injury. Scientific Reports. 2016 Sep 26;6:34167.
Lee WJ, Liu SH, Chiang CK, Lin SY, Liang KW, Chen CH, Tien HR, Chen PH, Wu JP, Tsai YC, Lai DW, Chang YC, Sheu WH, Sheu ML* Aryl Hydrocarbon Receptor Deficiency Attenuates Oxidative Stress-Related Mesangial Cell Activation and Macrophage Infiltration and Extracellular Matrix Accumulation in Diabetic Nephropathy.. Antioxidants & Redox Signaling. 2016 Feb 1;24(4):217-231.
Previous Appointment
Deputy Secretary General, Taiwanese Society for Investigative Dermatology, Taiwan, 2012-2021
Visiting Scientist, National Heart, Lung, and Blood Institute (NHLBI) of the NIH, USA, 2006
Visiting Scientist, Uniformed Services University of the Health Sciences, Department of Dermatology, USA, 2006
Specialty
Tuberous Sclerosis Complex; Atopic Dermatitis; Environmental and Occupational Dermatology; Clinical Immunology
Publications
Peng JH, Tu HP and Hong CH. A population-based study to estimate survival and standardized mortality of tuberous sclerosis complex (TSC) in Taiwan. Orphanet Journal of Rare Diseases 2021; 16(335):https://doi.org/10.1186/s13023-021-01974-3 (SCI). (Impact factor: 3.523;Rank: 32.87%)
Yu S, Li LH, Lee CH, Jeyakannu P, Wang JJ, Hong CH. Arsenic leads to autophagy of keratinocytes by increasing aquaporin 3 expression. Scientific Reports 2021; 11:17523 (SCI). (Impact factor: 3.998;Rank: 23.24%)
Lin EC, Tu HP, Hong CH. Halved Incidence of Scrub Typhus after Travel Restrictions to Confine a Surge of COVID-19 in Taiwan. Pathogens 2021; 10(11):1386 (SCI). (Impact factor: 3.018;Rank: 47.43%)
Hong CH; Lin SH; Clausen BE; Lee CH. Selective AhR knockout in langerin-expressing cells abates Langerhans cells and polarizes Th2/Tr1 in
epicutaneous protein sensitization. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (PNAS) 2020; 117(23):12980-12990 (SCI). (Impact factor: 9.412;Rank: 10.56%)
Hong CH, Ho JC, Lee CH. Steroid Receptor RNA Activator, a Long Noncoding RNA, Activates p38, Facilitates Epithelial-Mesenchymal Transformation, and Mediates Experimental Melanoma Metastasis. J Invest Dermatol. 2020; 140(7):1355-1363 (SCI). (Impact factor: 7.143;Rank: 3.68%)
Lee CH, Ho JC, Hong CH. Targeting steroid receptor RNA activator (SRA), a long non-coding RNA, enhances melanogenesis through activation of TRP1 and inhibition of p38 phosphorylation.PLoS One 2020;15(8):e0237577. doi: 10.1371/journal.pone.0237577. eCollection 2020.
Hong CH, Lin SH, Lee CH. CCL21 Induces mTOR-dependent MALAT1 Expression, Leading to Cell Migration in Cutaneous T-Cell Lymphoma. in vivo. 2019 May 1;33(3):793-800.
Hong CH, Ho JC, Lee CH. Steroid receptor RNA activator (SRA), a long noncoding RNA, activates p38, facilitates epithelial mesenchymal transformation, and experimental melanoma metastasis. J Invest Dermatol. 2020 Jan 13. pii: S0022-202X(19)33503-1. doi: 10.1016/j.jid.2019.09.028. [Epub ahead of print] PMID: 31945347
Yu S, Tu HP, Yu CL, Lee CH, Hong CH. Is psoriasis an independent risk factor of renal disease? A nationwide retrospective cohort study from 1996 to 2010. Dermatologica Sinica 2017; 35:78-84.
Hong CH, Lee CH, Yu HS, Huang SK*. Benzopyrene, a major polyaromatic hydrocarbon in smoke fume, mobilizes Langerhans cells and polarizes Th2/17 responses in epicutaneous protein sensitization through the aryl hydrocarbon receptor. International Immunopharmacology 2016 Jul;36:111-117 (SCI, IF=2.551)
Hong CH, Tu HP, Lin JR , and Lee CH*. An estimation of the incidence of tuberous sclerosis complex in a nationwide retrospective cohort study (1997-2010). British journal of Dermatology 2016 Jun;174(6):1282-9. (SCI, IF=4.317)
Hong CH, Chang KL, Wang HJ, Yu HS*, Lee CH*. IL-9 induces IL-8 production via STIM1 activation and ERK phosphorylation in epidermal keratinocytes: A plausible mechanism of IL-9R in atopic dermatitis. Journal of Dermatological Science. 2015 Jun;78(3):206-14. (SCI, IF=3.739)
Hong CH, Lee CH, Chen GS, Chang KL, Yu HS*. STAT3-dependent VEGF production from keratinocytes abrogates dendritic cell activation and migration by arsenic: a plausible regional mechanism of immunosuppression in arsenical cancers.
Chemico-Biological Interactions. 2015 Feb 5;227:96-103.
Hong CH, Yu HS, Ko YC, Chang WC, Chuang HY, Chen GS, Lee CH*. Functional Regulation of Interleukin-31 Production by its Genetic Polymorphism in Patients with Extrinsic Atopic Dermatitis. Acta Dermato-Venereologica. 2012 Aug 6;92(4):430-432
Seibert D, Hong CH, Takeuchi F, Olsen C, Hathaway O, Moss J, Darling TN*. Recognition of Tuberous Sclerosis in Adults Women: Delayed Presentation with Life-Threatening Consequences.' Annals of Internal Medicine. 2011 June; 154(12): 806-814.
Aldrich S, Hong CH(co-first author), Groves L, Olsen C, Moss J, Darling TN*. Acral Lesions in Tuberous Sclerosis Complex: Insights into Pathogenesis. Journal of the American Academy of Dermatology. 63(2): 244-251, 2010 May
Avila NA*, Dwyer AJ, Rabel A, Darling T, Hong CH, Moss J. CT of Sclerotic Bone Lesions: Imaging Features Differentiating Tuberous Sclerosis Complex with Lymphangioleiomyomatosis from Sporadic Lymphangioleiomymatosis. Radiology, 254(3):851-7, 2010 Mar.
Hong CH, Darling TN, Lee CH*. Prevalence of Tuberous Sclerosis Complex in Taiwan: A national population-based study. Neuroepidemiology, 33(4): 335-341, 2009
Hong CH, Lee CH, Chang LW, Chiou MH, Hsieh MC, Kao YH, Yu HS*. Anti-endothelial cell IgG from patients with chronic arsenic poisoning induces endothelial proliferation and VEGF-dependent angiogenesis. Microvascular Research, 76; 194-201, 2008
Sparling JD, Hong CH, Brahim JS, Moss J, Darling TN*. Oral Findings in 58 Adults with Tuberous Sclerosis Complex. Journal of the American Academy of Dermatology, 56: 786-790, 2007.
Hong CH, Hou MF, Chen GS. Microcystic adnexal carcinoma of the nipple. Dermatologica Sinica, 22: 153-158, 2004.Hong CH*, Chen GS, Yu HS, Chuang HY. Occupational radiodermatitis: an accidental overexposure to Ir192 gamma rays. Dermatologica Sinica 20: 128-135, 2002.
Professional and Research Experience:
Professional: Toxicology, Toxicity test, Ophthalmic Pharmacology
(毒理學、毒性試驗、眼科藥理學)
Experiences:
衛福部基因改造食品審議委員會委員
衛福部基因改造食品諮議會委員
衛福部健康食品審議委員會委員
衛福部實驗室認證審議小組(GLP領域)委員
衛福部牛海綿狀腦病專家諮詢會委員
衛福部藥品諮議小組委員
農委會基因改造飼料及飼料添加物審議小組委員
Selected Publications:
Hsu, TJ, Nepali, K, Tsai, CH, Lin FL, Hsiao, G, Lai, MJ*, Cheng YW* (2021) The HDAC/HSP90 Inhibitor G570 Attenuated Blue Light-Induced Cell Migration in RPE Cells and Neovascularization in Mice through Decreased VEGF Production. Molecules. (26):4359--4378.
YD Chang, CH Li, CH Tsai, Cheng YW, Kang JJ and Lee CC (2020). Aryl hydrocarbon receptor deficiency enhanced airway inflammation and remodeling in a murine chronic asthma model. FASEB JOURNAL, 1-14.
Tsai CH, Lee Y, Li CH, Cheng YW* and Kang JJ* (2020) Down-regulation of aryl hydrocarbon receptor intensifies carcinogen-induced retinal lesion via SOCS3-STAT3 signaling. Cell Biology and Toxicology. Feb;1867(2):118564
Tsai CH, Li CH, Liao PL, Cheng YW* and Kang JJ* (2019) Aza-PBHA, a potent histone deacetylase inhibitor, inhibits human gastric cancer cell migration via PKCa-mediated AHR-HDAC interactions. BBA- Molecular Cell Research. major revision. 2020 Feb;1867(2):118564.
Lin CH, Lin CHWu MR, Huang WJ, Chow DSL, Hsiao G, Cheng YW* (2019) Low-luminance blue light-enhanced phototoxicity in A2E-laden RPE cell cultures and rats. International Journal of Molecular Sciences. (20):1799-1818.
Liao PL, Lin CH, Ho JD, Li CH, Tsai CH, Chiou GCY, Kang JJ, Cheng YW* (2017) Anti-inflammatory properties of shikonin contribute to improved early-stage diabetic retinopathy. Scientific Report , Mar 21; 7:44985.
Tsai CH, Li CH, Cheng YW, Lee CC, Liao PL, Lin CH; Huang SH, Kang JJ (2017). The inhibition of lung cancer cell migration by AHR-regulated autophagy. Scientific Report, 14; 7:41927. Lin CH, Wu MR, Li CH, Cheng HW, Huang SH, Tasi CH; Ho JD, Kang JJ; Hsiao G; Cheng YW* (2017) Periodic exposure to smartphone-mimic low-luminance blue light induces retina damage through Bcl-2/BAX-dependent apoptosis. Toxicological Science, May 1;157(1):196-210.
Li CH, Liu CW, Tsai CH, Peng YJ, Yang YH, Liao PL, Lee CC, Cheng YW*, Kang JJ* (2017) Cytoplasmic aryl hydrocarbon receptor regulates glycogen synthase kinase 3 beta, accelerates vimentin degradation, and suppresses epithelial-mesenchymal transition in non-small cell lung cancer cellsL. Archive in Toxicology, May; 91(5):2165-2178.
Lee CC, Yang WH, Li CH, Cheng YW, Tsai CH, Kang JJ (2016) Ligand-independent aryl hydrocarbon receptor inhibits lung cancer. Cancer Lette Jul 1, 376(2):211-217.
Professional and Research Experience:
1996/08 to 2003/06 Chung Shan Medical University (Associate Professor)
2003/07 to 2006/01 Chung Shan Medical University (Professor)
2004/03 to 2006/01 Division of Environmental Health and Occupational Medicine, NHRI (Adjunct Associate Investigator)
2006/01 to 2007/12 Division of Environmental Health and Occupational Medicine, NHRI (Associate Investigator)
2007/12 to 2016/03 Division of Environmental Health and Occupational Medicine, NHRI (Investigator)
2016/04 to 2019/01 National Institute of Environmental Health Sciences, (Associate Director)
2016/03 to present National Institute of Environmental Health Sciences, NHRI (Investigator)
2019/01 to 2020/07 National Institute of Environmental Health Sciences, NHRI (Acting Director)
Awards and Honors:
American Board certified Toxicologist since 2014
Toxicology Society of Taiwan certified Toxicologist since 2015
Selected Publications:
Chou, W.-C., Hsu, Chin-Yu, Ho, C.-C., Hsieh, J.-H. H., Chiang, H.-C., Tsou, T.- C., Chen, Y.-C.*, Lin, P.* (2017, Nov). Development of an in vitro-based risk assessment framework for predicting ambient particulate matter-bound polycyclic aromatic hydrocarbon-activated toxicity pathways. Environmental Science & Technology, 51, 14262–14272.
Ho, C. C., Wu, W. T., Chen, Y. C., Liou, S. H., Yet, S. F., Lee, C. H., Tsai, H. T., Weng, C. Y., Tsai, M. H., Lin, P.* (2019, Jan). Identification of osteopontin as a biomarker of human exposure to fine particulate matter. Environmental Pollution, 245, 975-985.
Chou, W.-C., Chen, Y.-C., Yet, S.-F., Weng, C.-Y., Tsai, H.-T., Hsu, J.-F., Lin, P.* (2020, Feb). Identification of ambient fine particulate matter components related to vascular dysfunction by analyzing spatiotemporal variations. Science of The Total Environment, 719, 137243.
Ho, C.C., Chen, Y.C., Tsai, M.H., Tsai, H.T., Weng, C.Y., Yet, S.F., Lin, P.* (2021, May). Ambient particulate matter induces vascular smooth muscle cell phenotypic changes via nox1/ros/nf-kappab dependent and independent pathways: Protective effects of polyphenols. Antioxidants (Basel), 10(5), 782.
Professional and Research Experience:
2014-present Distinguished Professor National Cheng Kung University,
2009-2014 Full Professor National Cheng Kung University,
2013/Mar.-July Visiting Scientist University of Texas M.D.Anderson Cancer
Awards and Honors:
World’s Top 2% Scientists 2020
Distinguished professor in National Cheng Kung University 2017-2020, 2020-2023
Outstanding achievement award, Asia Pacific Society for Biology and Medical Sciences (APSBMS), 2019
Selected Publications:
1. B-H Mao, Y-K Luo, B-J Wang, C-W Chen, F-Y Cheng, Y-H Lee, S-J Yan* and Y-J Wang*. Use of an In silico Knowledge Discovery Approach to Determine Mechanistic Studies of Silver Nanoparticles-induced Toxicity from In vitro to In vivo. Particle and Fibre Toxicology. 2022, 19:6 (SCI IF= 9.4 JCR 2020) (Corresponding author)
2. Y-Y Chen, Y-H Lee, B-J Wang, R-J Chen* and Y-J Wang*. Skin Damage Induced by Zinc Oxide Nanoparticles Combined with UVB is Mediated by Activating Cell Pyroptosis via the NLRP3 Inflammasome-Autophagy-Exosomal Pathway. Particle and Fibre Toxicology. 2022, 19:2 (SCI IF= 9.4, JCR 2020) (Corresponding author)
3. Z-Y Chen, Y-C Su, F-Y Cheng, S-J Yan* and Y-J Wang*. Lifetime bioaccumulation of silver nanoparticles accelerates functional aging by inactivating antioxidant pathways, an effect reversed by pterostilbene. Environ. Sci.: Nano, 2021, 8, 3774. (SCI IF=8.131., JCR 2020) (Corresponding author)
4. Y-H Wu; W-S Wu; L-C Lin; C-S Liu; S-Y Ho; B-J Wang; B-M Huang; Y-L Yeh; H-W Chiu; W-L Yang*; Y-J Wang*. Bortezomib enhances radiosensitivity in oral cancer through inducing autophagy-mediated TRAF6 oncoprotein degradation. J Exp Clin Canc Res. 2018, 37;91 (SCI IF=11.161, JCR 2020) (Corresponding author)
5. R-J Chen, P-H Wu, C-T Ho, T-D Way, M-H Pan, H-M Chen, Y-S Ho, Y-J Wang*. P53-dependent Down-regulation of hTERT Protein Expression and Telomerase Activity Induces Senescence in Lung Cancer Cells by Pterostilbene Treatment. Cell Death Dis. 10;8(8): e2985 (2017). (SCI IF=8.469, JCR 2020) (Corresponding author)
6. Y-J Wang, J-F Lin, L-H Cheng, W-T Chang, Y-H Kao, M-M Chang, B-J Wang and H-C Cheng. Pterostilbene prevents AKT-ERK axis-mediated polymerization of surface fibronectin on suspended lung cancer cells independently of apoptosis and suppresses metastasis. J. Hematol. Oncol. 10:72-85. (2017). (SCI IF=17.388, JCR 2020)
7. H-W Chiu, Y-L Yeh, Y-C Wang, W-J Huang, S-Y Ho, P Lin* and Y-J Wang*. Combination of the novel histone deacetylase inhibitor YCW1 and radiation induces autophagic cell death through the downregulation of BNIP3 in triple-negative breast cancer cells in vitro and in an orthotopic mouse model. Molecular Cancer. 15:46. (2016) (SCI IF=27.401, JCR 2020) (Corresponding author)
8. Y-H Lee, F-Y Cheng, H-W Chiu, J-C Tsai, C-Y Fang, C-W Chen* and Y-J Wang*. Cytotoxicity, oxidative stress, apoptosis and the autophagic effects of silver nanoparticles in mouse embryonic fibroblasts. Biomaterials. 35(16):4706-4715 (2014) (SCI IF= 12.479, JCR 2019) (Corresponding author)
9. Wang, Y.-J., Chang, H., Kuo, Y.-C., Wang, C.-K., Siaoa, S.-H., Chang, L. W. and Lin, P. Synergism between 2,3,7,8- tetrachlorodibenzo-p-dioxin and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone on lung tumor incidence in mice. J. Hazardous Materials. 186: 869-875 (2011) (SCI IF= 10.588, JCR 2020)
10. H-W Chiu, J-H Lin, Y-A Chen, S-Y Ho and Y-J Wang*. Combination treatment with arsenic trioxide and irradiation enhances cell-killing effects in human fibrosarcoma cells in vitro and in vivo through induction of both autophagy and apoptosis. Autophagy. 6: 353-365 (2010) (SCI IF= 16.016, JCR 2020) (Corresponding author)
11. H-W Chiu, S-Y Ho, H-R Guo and Y-J Wang*. Combination treatment with arsenic trioxide and irradiation enhances autophagic effects in U118-MG cells through increased mitotic arrest and regulation of PI3K/Akt and ERK1/2 signaling pathways. Autophagy. 5:472-483 (2009) (SCI IF= 16.016, JCR 2020) (Corresponding author)
Professional and Research Experience:
Professor, School of Respiratory Therapy, Taipei Medical University, Taiwan
Adjunct Associate Professor, School of Public Health, College of Public Health, Taipei Medical University, Taipei, Taiwan
Associate Editor, Frontiers in Medicine, Section of Pulmonary Medicine
Awards and Honors:
2021 World's Top 2% Scientists 2020 (全球前2%頂尖科學家榜單-2020年度科學影響力), Elsevier
2021 Best Paper of the Year Award on Aerosol and Air Quality Research (AAQR) (SCI; First author; Acute effects of pulmonary exposure to zinc oxide nanoparticles on brain in vivo)
Selected Publications:
Hsiao, T-C.#, Cheng, P-C.#, Chi, K.H., Wang, H-Y., Pan, S-Y., Kao, C., Lee, Y-L., Kuo, H-P., Chung, K.F., Chuang, H-C.* (2022) Interactions of chemical components in ambient PM2.5 with influenza viruses. Journal of Hazardous Materials 423, p127243.
Nguyen, T.T.#, Ho, S-C.#, Lu, Y-H., Chen, T-T., Lee, K-Y., Chen, K-Y., Wu, C-D., Chung, K.F., Kuo, H-P., Huynh, N.X.T., Hoang, B.D., Tran, P.C.T., Wu, S-M., Kou, H-Y., Lee, Y-L., Chuang, H-C.* (2021) Association between air pollution and lung lobar emphysema in COPD. Frontiers in Medicine-Pulmonary Medicine. 8, p705792.
Shih, C-H., Chen, J-K., Kuo, L-W., Cho, K-H., Hsiao, T-C., Lin, Z-W., Lin, Y-S., Kang, J-H., Lo, Y-C., Chuang, K-J., Cheng, T-J., Chuang, H-C.* (2018) Chronic pulmonary exposure to traffic-related fine particulate matter causes brain impairment in adult rats. Particle and Fibre Toxicology 15(1), p.44.
Chuang, H-C.*, Su, T-Y., Chuang, K-J., Hsiao, T-C., Lin, H-L., Hsu, Y-T., Pan, C-H., Lee, K-Y., Ho, S-C., Lai, C-H.* (2018) Pulmonary exposure to metal fume particulate matter cause sleep disturbances in shipyard welders. Environmental Pollution 232, p523-532.
Ba, K-J.#, Chuang, K-J.#, Chen, J-K., Hua, H-E., Shen, Y-L., Liao, W-N., Lee, C-H., Chen, K-Y., Lee, K-Y., Hsiao, T-C., Pan, C-H., Ho, K-F., Chuang, H-C.* (2017) Investigation into the pulmonary inflammopathology of exposure to nickel oxide nanoparticles in mice. Nanomedicine: Nanotechnology, Biology, and Medicine (E-Pub).
Professional and Research Experience:
2006.01- 2008.03 Associate Manager, Study Director, Level Biotechnology Ltd. Preclinical Testing Center
2008.04 - 2010.07 Postdoc fellowship, Graduate Institute of Toxicology, College of Medicine, National Taiwan University
2011.08 – 2012.08 Postdoc fellowship, School of pharmacy, Taipei Medicine University
2012.09 ~ 2017.02 Assistant Professor., Department of Physiology, School of Medicine, Taipei Medical University
2020.06 ~ General Secretary, The Chinese Physiological Society
Selected Publications:
Hsu HL, Chen HK, Tsai CH, Liao PL, Chan YJ, Lee YC, Lee CC, Li CH*. Aryl hydrocarbon receptor defect attenuates mitogen-activated signaling through leucine-rich repeats and immunoglobulin-like domains 1 (LRIG1)-dependent EGFR degradation. International Journal of Molecular Sciences. 2021 Sept 15; 22(18): 9988.
Chan YJ, Liao PL, Tsai CH, Cheng YW, Lin FL, Ho JD, Chen CY, Li CH* (2020) Titanium dioxide nanoparticles impair the inner blood-retinal barrier and retinal electrophysiology through rapid ADAM17 activation and claudin-5 degradation. Particle & Fibre Toxicology. 2021 Jan 9;18(1):4.
Chen CY, Liao PL, Tsai CH, Chan YJ, Cheng YW, Hwang LL, Lin KH, Yen TL, Li CH* (2019) Inhaled gold nanoparticles cause cerebral edema and upregulate endothelial aquaporin 1 expression, involving caveolin 1 dependent repression of extracellular regulated protein kinase activity. Particle & Fibre Toxicology 2019 Oct 16;16(1):37.
Li CH, Liu CW, Tsai CH, Peng YJ, Yang YH, Liao PL, Lee CC, Cheng YW*, Kang JJ*. (2017) Cytoplasmic aryl hydrocarbon receptor regulates glycogen synthase kinase 3 beta accelerates vimentin degradation, and suppresses epithelial-mesenchymal transition in non-small cell lung cancer cells. Archives Toxicology. 2017 May;91(5):2165-2178.
Li CH, Shyu MK, Jhan C, Cheng YW, Tsai CH, Liu CW, Lee CC, Chen RM, Kang JJ*. Gold Nanoparticles increase endothelial paracellular permeability by altering components of endothelial tight junctions, and increase blood-brain barrier permeability in mice. Toxicological Sciences, 2015;148:192-203.
Lin CD, Kou YY, Liao CY, Li CH, Huang SP, Cheng YW, Liao WC, Chen HX, Wu PL, Kang JJ, Lee CC*, Lai CH*. Zinc oxide nanoparticles impair bacterial clearance by macrophages. Nanomedicine (Lond). 2014;9(9):1327-39.
Li CH, Liao PL, Liu CW, Kao CC, Huang SH, Cheng YW, Kang JJ*. Zinc oxide nanoparticles induced intercellular adhesion molecule 1 expression requires Rac1/Cdc42, mixed-lineage kinase 3, and c-Jun N-terminal kinase activation in endothelial cells. Toxicological Sciences, 2012;126:162-72.
Li CH, Shen CC, Cheng YW, Huang SH, Wu CC, Kao CC, Liao JW, Kang JJ*. Organ biodistribution, clearance, and genotoxicity of orally administered zinc oxide nanoparticles in mice. Nanotoxicology, 2012;6:746-56.
Professional and Research Experience:
Post-doc, Stanford Cardiovascular Institute (2016-2019)
Post-doc, Department and Graduate Institute of Pharmacology, College of Medicine, National Taiwan University (2015)
Awards and Honors:
Einstein Program, Young Scholar Fellowship, Taiwan Ministry of Science and Technology (2019-2023)
North American Cannabis Summit Scholarship, Tobacco-Related Disease Research Program (TRDRP) of California (2019)
Selected Publications (5 years):
C.W. Huang, S.Y. Lee, T.T. Wei, Y.H. Kuo, S.T. Wu, H.C. Ku. A novel caffeic acid derivative prevents renal remodeling after ischemia/ reperfusion injury. Biomed & Pharmacother. 2021 Aug 13;142:112028
C.K. Luo, P.H. Chou, S.K. Ng, W.Y. Lin, T.T Wei. Cannabinoids orchestrate cross-talk between cancer cells and endothelial cells in colorectal cancer. Cancer Gene Ther. 2021 May 18
X.M. Ouyang, Y. Liu, Y. Zhou, J. Guo, T.T. Wei, C. Liu, B. Lee, B.B. Chen, A. Zhang, K.M. Case, L. Wang, N.G. Kooreman, A. Habtezion, E.G. Engleman, J.C. Wu. Antitumor effects of iPSC-based cancer vaccine in pancreatic cancer. Stem Cell Reports. 2021 May 5;S2213-6711(21)00199-5
C.T. Chen, S. Salunke, T.T. Wei, Y.A. Tang, Y.C. Wang. Fluorescent Nanohybrids from ZnS/CdSe Quantum Dots Functionalized with Triantennary, N-Hydroxy-p-(4-arylbutanamido)benzamide/Gallamide Dendrons That Act as Inhibitors of Histone Deacetylase for Lung Cancer. ACS Appl. Bio Mater. 2021 Feb
T.T. Wei, Y.T. Lin, S.P. Tang, C.K. Luo, C.T. Tsai, C.T. Shun, C.C. Chen. Metabolic targeting of HIF-1α potentiates the therapeutic efficacy of oxaliplatin in colorectal cancer. Oncogene. 2020 Jan;39(2):414-427
N.G. Kooreman, Y.K. Kim, P.E. Almeida, V. Termglinchan, S. Diecke, N.Y. Shao, T.T. Wei, H. Yi, D. Dey, R. Nelakanti, T.P. Brouwer, D.T. Paik, I. Sagiv-Barfi, A. Han, H.A. Quax, J.F. Hamming, R. Levy, M.M. Davis, and J.C. Wu. iPSC-Based Cancer Vaccination: An Autologous Stem Cell Vaccine against Cancer. Cell Stem Cell. 2018 Apr 5;22(4):501-513
W.H. Lee, W.Y. Chen, N.Y. Shao, D.Xiao, X. Qin, N. Baker, H.R. Bae, T.T. Wei, Y. Wang, P. Shukla, H. Wu, K. Kodo, S.G Ong, J.C. Wu. Comparison of Non-Coding RNAs in Exosomes and Functional Efficacy of Human Embryonic Stem Cell- versus Induced Pluripotent Stem Cell-Derived Cardiomyocytes. Stem Cells. 2017 Oct;35(10):2138-2149
Professional and Research Experience:
2016 - Distinguished Professor, School of Medicine, National Yang-Ming University
2010 - Professor, Institute of Pharmacology/Medical School, National Yang-Ming University
2007 Visiting Researcher, Molecular Biochemistry, The Scripps Research Institute (TSRI), CA, USA
2006 - Associate professor, Institute of Clinical Medicine & Medical School, National Yang-Ming University
2005 - Attending physician, Department of Medical Research & Education, TVGH
2003-2004 Chief, the section of Ophthalmology, Tauyuan Veterans Hospital
2002 Post-Doc, City of Hope, Bone Marrow Transplant/Stem Cell Lab, CA, USA
2000-2002 Attending physician, Department of Ophthalmology, TVGH
1994-1999 Resident/Fellow training, Ophthalmology, Taipei Veterans General Hospital, Taiwan
Awards and Honors:
2020 17th National Innovation Award, Academic Research & Best Potential Investment, Taiwan
2019 16th National Innovation Award, Medical Research and Innovation, Taiwan
2018 APAO 2018 Achievement Award, Asia-Pacific Academy of Ophthalmology, Australia·
2018 「Future Technology of Breaking Through and Excellent Team 」Ministry of Science Technology (MOST)
2017 Outstanding Research Award of Ministry of Science Technology 2nd (MOST), Taiwan
Selected Publications:
Chien CS, Li Julie YS, YC, Wang ML, Aliaksandr A Yarmishyn, Tsai PH, Juan CC, Phu Neugyn, Cheng HM, Huo TI, Chiou SH *, Chien Shu * (listed as co-corresponding author).METTL3-dependent N6-methyladenosine RNA Modification Mediates the Atherogenic Inflammatory Cascades in Vascular Endothelium. Proc. Natl. Acad. Sci. USA 2021 FEB (In press) (IF= 9.412; RANK=8/71;Multidisciplinary Sciences)
SJ Chou,Yang P, Ban Q, Yang YP, Wang ML, Chien CS, Chen SJ, Sun N, Zhu Y, Wang F, Zhang RY, Nguyen VQ, Liu Wnfei, Chen M, Jonas SJ, Weiss PS, Tseng HR*, Chiou SH*. Dual Supramolecular Nanoparticle Vectors Enable CRISPR/Cas9‐Mediated Knockin of Retinoschisin 1 Gene—A Potential Nonviral Therapeutic Solution for X‐Linked Juvenile Retinoschisis. Advanced Science 2020 April 16;7(10):1903432 (IF=15.804;RANK=9/103; NANOSCIENCE & NANOTECHNOLOGY )
Yang P, Chou SJ, Li J, Hui W, Liu W, Sun N, Zhang RY, Zhu Y, Tsai ML, Lai HI, Smalley M, Zhang X, Chen J, Romero Z, Liu D, Ke Z, Zou C, Lee CF, Jonas SJ, Ban Q, Weiss PS*, Kohn DB*, Chen K*, Chiou SH*, Tseng HR*.Supramolecular Nanosubstrate-Mediated Delivery System Enables CRISPR/Cas9 Knockin of Hemoglobin Beta Gene for Hemoglobinopathies. Science Advances 2020 Oct 23;6(43):eabb7107 (IF=13.116;RANK=4/71; MULTIDISCIPLINARY SCIENCES)
Tsai PH, Chien Y, Wang ML, Hsu CH, Laurent B, Chou SJ, Chang WC, Chien CS, Li HY, Lee HC, Huo TI, Hung JH, Chen CH, Chiou SH*.Ash2l interacts with Oct4-stemness circuitry to promote super-enhancer-driven pluripotency network. Nucleic Acids Res 2019 Sep 26. (IF= 11.147;RANK= 15/297; BIOCHEMISTRY & MOLECULAR BIOLOGY )
Chen HY, Wang ML, Laurent B, Hsu CH, Chen MT, Lin LT, Shen J, Chang WC, Hsu J, Hung MC, Chen YW, Huang PI, Yang YP, Li CP, Ma HI, Chen CH, Lin WC, Chiou SH*. Musashi-1 promotes stress-induced tumor progression through recruitment of AGO2. Theranostics. 2020 Jan 1; 10(1):201-217. (IF= 8.651;RANK=10 /138; MEDICINE, RESEARCH & EXPERIMENTAL )
Professional and Research Experience:
Division Director of Division of Regeneration Medicine Technology, Biomedical Technology and Device Research Laboratories , ITRI (2017 to Present)
Deputy Chief Operating Officer of Center of Excellence for Combination Products, Biomedical Technology and Device Research Laboratories, ITRI (2014-2016)
Division Director of Division of Tissue Regeneration Product Technology, Biomedical Technology and Device Research Laboratories, ITRI (2012-2014)
Deputy Division Director of Division of Tissue Regeneration Product Technology, Biomedical Technology and Device Research Laboratories, ITRI (2010-2011)
Research Supervisor of Division of Combination Products, Biomedical Technology and Device Research Laboratories, ITRI (2008-2009)
Manager of Department of Cell Engineering Technology, Stem Cell and Cell Therapy Program, Biomedical Engineering Research Laboratory , ITRI (2006-2007)
Manager of Department of Neural Tissue Engineering Program, Division of Biomaterials and Tissue Engineering, Biomedical Engineering center, ITRI (2002-2005)
Researcher, Division of Biomaterials and Tissue Engineering, Biomedical Engineering center , ITRI (2001-2002)
Awards and Honors:
• Quality award, ITRI, Taiwan (2020)
• Engineering Science Award , ITRI, Taiwan (2020)
• Certificate of the16th National Innovation Award , Institute for Biotechnology and Medicine Industry , Taiwan (2017, 2019, 2020)
• First Place, Annual Invention Award, ITRI, Taiwan (2019)
• Outstanding Research Award, ITRI, Taiwan (2018, 2019)
Selected Publications:
Three-Dimensional Printed Porous Titanium Screw with Bioactive Surface Modification for Bone-Tendon Healing: A Rabbit Animal Model, Int J Mol Sci, . 2020 May 21;21(10):3628.
Dendritic cells treated with a prostaglandin I 2 analog, iloprost, promote antigen-specific regulatory T cell differentiation in mice, Int Immunopharmacol, 2020 Feb;79:106106.
Human Wharton's Jelly Mesenchymal Stem Cell-Mediated Sciatic Nerve Recovery Is Associated with the Upregulation of Regulatory T Cells, Int J Mol Sci, 2020 Aug 31;21(17).
One injection for one-week controlled release: In vitro and in vivo assessment of ultrasound-triggered drug release from injectable thermoresponsive biocompatible hydrogels, Ultrason Sonochem, 2020 Apr;62:104875.
Augmentation of DMLS Biomimetic Dental Implants with Weight-Bearing Strut to Balance of Biologic and Mechanical Demands: From Bench to Animal, Materials (Basel) 2019 Jan 7.
Professional and Research Experience:
Attending Physician, National Taiwan University Hospital
Division Chief, Division of Medical Affairs, Department of Health, Taipei City Government, Taiwan
Deputy Secretary General, Taiwan Medical Association
Chairperson of Pediatric Emergency Committee, Taiwan Society of Emergency Medicine
Senior Technical Specialist, Department of Medical Affairs, Ministry of Health and Welfare, Taiwan
Deputy Director, National Biobank Consortium of Taiwan
Chief Executive officer, Taiwan Organ Registry and Sharing Center
Awards and Honors:
The Silver Medal Award, the 1st The Creative Clinical Application of POCUS Competition, Taiwan Society of Ultrasound in Medicine, 2020
Best Oral Award Winners, the 16th World Federation for Ultrasound in Medicine and Biology Congress, Taipei, 2017
Selected Publications:
Development of a nursing-specific Mini-CEX and evaluation of the core competencies of new nurses in postgraduate year training programs in Taiwan. BMC Med Educ. 2019;19(1):270
The development and use of a pharmacist-specific Mini-CEX for postgraduate year trainees in Taiwan. BMC Med Educ. 2019;19(1):165.
Antepartum urinary tract infection and postpartum depression in Taiwan - a nationwide population- based study. BMC Pregnancy Childbirth. 2018;18(1):79.
Economic Conditions May Contribute to Increased Violence toward Children: A Nationwide Population-Based Analysis of Pediatric Injuries in Taiwanese Emergency Departments. Int J Environ Res Public Health. 2018;15(2):182.
Professional and Research Experience:
Committee Member, Regenerative Medicine Consultation Board, TFDA, Ministry of Health and Welfare (MOHW), Taiwan (衛福部 食品藥物管理署再生醫學諮議小組), 2020 to present.
Committee Member, Ministry of Health and Welfare (MOHW), Taiwan (衛福部 醫事司細胞治療特管辦法定價委員會), 2019 to present.
Committee member, Asia Cellular Therapy Organization (ACTO) 2018 to present.
President, Taiwan Association of Cell Therapy (TACT), 2020 to present.
Secretary in General, Taiwan Association of Cell Therapy (TACT), 2014 to 2020.
Secretary in General, The Pharmacological Society in Taiwan, 2020 to present.
Member of Director Board, Taiwan Society for Stem Cells Research (TSSCR), 2012 to present.
Member of Director Board, Formosan Association of Regenerative Medicine, 2015 to present.
Awards and Honors:
第17屆(2020年)國家新創獎 -新創精進獎
第16屆(2019年)國家新創獎 - 學研新創
2012- ISSCR Travel Ward
Honorable Mention Award for “Competition for Originality in Biotechnology”: by the Industrial Development Bureau, Ministry of Economic Affairs, 2009.
Post-doctoral research fellow scholarship, Academia Sinica 2003-2005.
Selected Publications:
Zhuang WZ, Lin YH, Su LJ, Wu MS, Jeng HY, Chang HC, Huang YH, Ling TY. (2021) Mesenchymal Stem/Stromal Cell-Based Therapy: Mechanism, Systemic Safety and Biodistribution for Precision Clinical Applications. J Biomed Sci. 14;28(1):28. doi: 10.1186/s12929-021-00725-7.
Huang AP, Hsu YH, Wu MS, Tsai HH, Su CY, Ling TY, Hsu SH, Lai DM. (2020) Potential of stem cell therapy in intracerebral hemorrhage. Mol Biol Rep. Jun;47(6):4671-4680. doi: 10.1007/s11033-020-05457-9. Epub 2020 May 15.
Tsai TH, Ling TY, Lee CH. (2020) Adoption of Regulations for Cell Therapy Development: Linkage Between Taiwan and Japan. Clin Transl Sci. May 14. doi: 10.1111/cts.12813.
Lin SC, Liou YM, Ling TY, Chuang YH, Chiang BL. (2019) Placenta-Derived Mesenchymal Stem Cells Reduce the Interleukin-5 Level Experimentally in Children with Asthma. Int J Med Sci. 20;16(11):1430-1438.
Su LJ, Lin HH, Wu MS, Pan L, Yadav K, Hsu HH, Ling TY, Chen YT, Chang HC. (2019) Intracellular Delivery of Luciferase with Fluorescent Nanodiamonds for Dual-Modality Imaging of Human Stem Cells. Bioconjug Chem. 30(8):2228-2237.
Professional and Research Experience:
2003/04~2003/08 Post-doctoral fellow in Human Genetics in the Johns Hopkins University
2003/08~2004/07 Attending physician, Department of Internal Medicine, Yun-Lin Hospital
2004/07~ Attending physician, Department of Internal Medicine, National Taiwan University Hospital
2011/08~ Professor, Department of Laboratory Medicine and Internal Medicine, National Taiwan University College of Medicine
Awards and Honors:
2011 Distinguished Research Award, National Taiwan University Hospital
2009 Ching-Hsin Medical Award
2007 Recipient of the Teaching Award for Excellence in Medical Education
The First Place Award of the poster session of Graduate Student Association, the Johns Hopkins University, Baltimore, 2003.
The Travel Award of 44th Annual Meeting of the American Hematology Society, Philadelphia, 2002
Selected Publications:
Lin CC, Yao CY, Hsu YC, Hou HA, Yuan CT, Li YH, Kao CJ, Chuang PH, Chiu YC, Chen Y, Chou WC, Tien HF. Knock-out of Hopx disrupts stemness and quiescence of hematopoietic stem cells in mice. Oncogene 2020, Jul;39(28):5112-5123. (corresponding author)
Wang YH, Lin CC, Yao CY, Hsu CL, Hou HA, Tsai CH, Chou WC, Tien HF. A 4-gene leukemic stem cell score can independently predict the prognosis of myelodysplastic syndrome patients. Blood Adv. 2020 Feb 25;4(4):644-654. (corresponding author)
Hsu YC, Chen TC, Lin CC, Yuan CT, Hsu CL, Hou HA, Kao CJ, Chuang PH, Chen YR, Chou WC, Tien HF. Phf6-null hematopoietic stem cells have enhanced self-renewal capacity and oncogenic potentials. Blood Adv. 2019 Aug 13;3(15):2355-2367. (corresponding author)
Hsu YC, Chiu YC, Lin CC, Kuo YY, Hou HA, Tzeng YS, Kao CJ, Chuang PH, Tseng MH, Hsiao TH, Chou WC, Tien HF. The distinct biological implications of Asxl1 mutation and its roles in leukemogenesis revealed by a knock-in mouse model. J Hematol Oncol. 2017 Jul 11;10(1):139. (corresponding author)
Lin CC, Hsu YC, Li YH, Kuo YY, Hou HA, Lan KH, Chen TC, Tzeng YS, Kuo YY, Kao CJ, Chuang PH, Tseng MH, Chiu YC, Chou WC, and Tien HF. Higher HOPX Expression is Associated with Distinct Clinical and Biological Features and Predicts Poor Prognosis in de novo Acute Myeloid Leukemia. Haematologica 2017; Jun;102(6):1044-1053. (corresponding author)
Professional and Research Experience:
02/2002-07/2009 Assistant Professor, Department of Clinical Laboratory Sciences and Medical Biotechnology, National Taiwan University College of Medicine, Taipei, Taiwan
08/2009-07/2013 Associate professor, Department of Clinical Laboratory Sciences and Medical Biotechnology, National Taiwan University College of Medicine, Taipei, Taiwan
08/2013-present Professor, Department of Clinical Laboratory Sciences and Medical Biotechnology, National Taiwan University College of Medicine, Taipei, Taiwan
Awards and Honors:
Ching-Hsin Medical Award (College of Medicine, National Taiwan University)(2014)
Selected Publications:
CT Huang, TL Chao, HC Kao, YH Pang, WH Lee, CH Hsieh, SY Chang*, HC Huang *, HF Juan *. Enhancement of the IFN-β-induced host signature informs repurposed drugs for COVID-19. Heliyon 6(12):e05646. * equal contribution.
KY Huang, MS Lin, TC Kuo, CL Chen, CC Lin, YC Chou, TL Chao, YH Pang, HC Kao, RS Huang, S Lin, SY Chang*, Pan-Chyr Yang*. Humanized COVID-19 decoy antibody effectively blocks viral entry and prevents SARS-CoV-2 infection. EMBO Molecular Medicine e12828. * equal contribution. DOI: 10.15252/emmm.202012828
YW Cheng, TL Chao, CL Li, MF Chiu, HC Kao, SH Wang, YH Pang, CH Lin, YM Tsai, WH Lee, MH Tao, TC Ho, PY Wu, LT Jang, PJ hen, SY Chang*, SH Yeh*. Furin Inhibitors Block SARS-CoV-2 Spike Protein Cleavage to Suppress Virus Production and Cytopathic Effects. Cell Reports 33(2):108254. * equal contribution. https://doi.org/10.1016/j.celrep.2020.108254
WD Liu, SY Chang (Co-first), JT Wang, MJ Tsai, CC Hung, CL Hsu, SC Chang. Prolonged virus shedding even after seroconversion in a patient with COVID-19. J Infect. 2020 Apr 10:S0163-4453(20)30190-0.
TL Chao, SY Gu, PH Lin, YT Chou, TY Ling, SY Chang*. Characterization of Influenza A Virus Infection in Mouse Pulmonary Stem/Progenitor Cells. Front Microbiol. 2020 Jan 21;10:2942. doi: 10.3389/fmicb.2019.02942.
Professional and Research Experience:
Taiwan Society of Pathology
Taiwan Society of Clinical Pathology and Laboratory Medicine
Taiwanese Society of Molecular Medicine
International Association of Therapeutic Drug Monitoring and Clinical Toxicology
Association for Molecular Pathology
Awards and Honors:
The Phi Tau Phi Scholastic Honor Society of Republic of China
Selected Publications:
1. High PD-L1 expression correlates with primary resistance to EGFR-TKIs in treatment naïve advanced EGFR-mutant lung adenocarcinoma patients, Kuo-Hsuan Hsu, Yen-Hsiang Huang, Jeng-Sen Tseng, Kun-Chieh Chen, Wen-Hui Ku, Kang-Yi Su, Jeremy J.W. Chen, Huei-Wen Chen, Sung-Liang Yu, Tsung-Ying Yang, Gee-Chen Chang, Lung Cancer 127 (2019) 37–43.
2. Characteristics and Predictive Value of PD-L1 Status in Real-World Non–Small Cell Lung Cancer Patients, Jeng-Sen Tseng, Tsung-Ying Yang, Chih-Ying Wu, Wen-Hui Ku, Kun-Chieh Chen, Kuo-Hsuan Hsu, Yen-Hsiang Huang, Kang-Yi Su, Sung-Liang Yu, and Gee-Chen Chang, J Immunotherapy 2018;41:292–299.
Professional and Research Experience:
2004–2004 Junior Researcher
Department of Chemistry, Utrecht University, the Netherlands
2005–2006 Netherlands Ramsay Fellow of the Royal Netherlands Academy of Arts and Sciences
Department of Chemistry, University of Cambridge, UK
2006–2008 Human Frontier Science Program (HFSP) Long-term Fellow
Department of Chemistry, University of Cambridge, UK
2009–2010 Research Associate
Department of Chemistry, University of Cambridge, UK
2010–2011 Assistant Professor
Institute of Bioinformatics and Structural Biology, National Tsing Hua University, Taiwan
2011–2017 Assistant Research Fellow
Institute of Biological Chemistry, Academia Sinica, Taiwan
2017– Associate Research Fellow with tenure
Institute of Biological Chemistry, Academia Sinica, Taiwan
2018– Adjunct Associate Professor
Institute of Biochemical Sciences, National Taiwan University, Taiwan
Awards and Honors:
2020-2024 Career Development Award, Academia Sinica
2010-2015 Outstanding Scholar Award, Foundation for the Advancement of Outstanding Scholarship, Taiwan
2010-2013 Career Development Award, International Human Frontier Science Program
2006–2008 Long-term Fellowship, International Human Frontier Science Program
2005–2006 Netherlands Ramsay Fellowship, Netherlands Royal Academy of Arts and Sciences (KNAW)
Selected Publications:
C.W. Kuo, T.J. Yang, Y.C. Chien, Yu PY, S.-T.D. Hsu* & Khoo KH* "Distinct shifts in site-specific glycosylation pattern of SARS-CoV-2 spike proteins associated with arising mutations in the D614G and Alpha variants" Glycobiology (2021) accepted
S.C. Su, T.J. Yang, P.Y. Yu, K.H. Liang, W.Y. Chen, C.W. Yang, H.T. Lin, M.J. Wang, R.M. Lu, H.C. Tso, M.J. Chung, T.Y. Hsieh, Y.L. Chang, S.C. Lin, F.Y. Hsu, F.Y. Ke, Y.H. Wu, Y.C. Hwang, I.J. Liu, J.J. Liang, C.C. Liao, H.Y. Ko, C.P. Sun, P.Y. Wu, J.T. Jan, Y.C. Chang, Y.L. Lin*, M.H. Tao*, S.-T.D. Hsu* & H.C. Wu* "Structure-guided antibody cocktail for prevention and treatment of COVID-19" PLoS Pathog. (2021) in press doi.org/10.1371/journal. ppat.1009704
T.J. Yang, P.T. Yu, Y.C. Chang & S.-T.D. Hsu* "D614G mutation in the SARS-CoV-2 spike protein enhances viral fitness by desensitizing it to temperature-dependent denaturation" J. Biol. Chem. (2021) 297(4), 10238 doi: 10.1016/j.jbc.2021.101238
T.J. Yang, P. Yu, Y.C. Chang, K.H. Liang, H.C. Tso, M.R. Ho, W.Y. Chen, H.T. Lin, H.C. Wu & S.-T.D. Hsu* "Effect of SARS-CoV-2 B.1.1.7 mutations on spike protein structure and function" Nat. Struc. Mol. Biol. (2021) 28(9), 731-739 doi: 10.1038/s41594-021-00652-z
T.J. Yang, T.C. Chang, T.P. Ko, P. Draczkowski, Y.C. Chien, Y.C. Chang, K.P. Wu, K.H. Khoo, H.W. Chang* & S.-T.D. Hsu* “Cryo-EM analysis of a feline coronavirus spike protein reveals a unique structure and camouflaging glycans” Proc. Natl. Acad. Sci. U. S. A. (2020) 117, 1438-46 doi: 10.1073/pnas.1908898117
Professional and Research Experience:
Postdoctoral research assistant, Institut de Biologie Structurale, CNRS, France
Postdoctoral research assistant, Biozentrum, University of Basel, Switzerland
Selected Publications:
Chiu SH, Ho WL, Sun YC, Kuo JC, and Huang JR*. "Phase separation driven by interchangeable properties in the intrinsically disordered regions of protein paralogs." (2022) submitted
Ho WL and Huang JR*. "The return of the rings: evolutionary role of aromatic residues in liquid-liquid phase separation." (2021) bioRxiv (under revision)
Chiang WC, Lee MH, Chen TC, and Huang JR*. "Interactions between the Intrinsically Disordered Regions of hnRNP-A2 and TDP-43 Accelerate TDP-43′s Conformational Transition." (2020) Int J Mol Sci. 21(16), 5930
Chiu YP, Sun YC, Qiu DC, Lin YH, Chen YQ, Kuo JC, and Huang JR*. "Liquid-liquid phase separation and extracellular multivalent interactions in the tale of galectin-3" (2020) Nat Comm 11:1229
Li HR, Chiang WC, Chou PC, Wang WJ, Huang JR*. "TAR DNA-binding protein 43 (TDP-43) liquid-liquid phase separation is mediated by just a few aromatic residues" (2018) J Biol Chem 293(16):6090-6098
Lin YH, Qiu DC, Chang WH, Yeh YQ, Jeng US, Liu FT, Huang JR*. "The intrinsically disordered N-terminal domain of galectin-3 dynamically mediates multisite self-association of the protein through fuzzy interactions." (2017) J Biol Chem 292(43) 17845–17856
Professional and Research Experience:
2008 – now, Professor, Institute of Bioinformatics and Structural Biology, National Tsing Hua University, Taiwan
Selected Publications:
1. Li, J.-Y., Chen, Y.-C., Lee, Y.-Z., Huang, C.-H., Sue, S.-C*. (2020) N-terminal backbone pairing shifts in CCL5-12AAA14 dimer interface: Structural significance of the FAY sequence. International Journal of Molecular Sciences. 21, E1689.
2. Chen, Y.-C., Chen, S.-P., Li, J.-Y., Chen, P.-C., Lee, Y.-Z., Li, K.-M., Zarivach, R., Sun, Y.-J., Sue, S.-C*. (2020) Integrative model to coordinate the oligomerization and aggregation mechanisms of CCL5. J Mol Biol. 432, 1143-1157.
3. Lee, Y.-Z., Sue, S.-C.* (2019) Salt-sensitive intein for large-scale polypeptide production. Methods in Enzymology, 621, 111-130, Elsevier.
4. Chen, Y.-P., Wu, H.-L., Boye, K., Pan, C.-Y., Chen, Y.-C., Pujol, N., Lin, C.-W., Chiu, L.-Y., Billottet, C., Alves, I. D., Bikfalvi, A.*, Sue, S.-C.* (2017) Oligomerization state of CXCL4 chemokines regulates G protein-couple receptor activation. ACS Chem Biol. 12, 2767-2778.
5. Boye, K., Pujol, N., I, D. A., Chen, Y.-P., Daubon, T., Lee, Y.-Z., Dedieu. S., Constantin, M., Bello, L., Rossi, M., Bjerkvig, R., Sue, S.-C., Bikfalvi, A., and Billottet, C. (2017) The role of CXCR3/LRP1 cross-talk in the invasion of primary brain tumors. Nature Commun. 8, 1571.
Professional and Research Experience:
08/2012~ Professor, Institute of Biochemistry and Molecular Biology, College of Medicine, National Taiwan University
08/2007~07/2012 Associate Professor, Institute of Biochemistry and Molecular Biology, College of Medicine, National Taiwan University
08/2001~07/2007 Associate and Assistant Professor, Institute of Biochemistry,, National Chung Hsing University
02/1999~07/2001 Postdoctoral Researcher, Department of Biochemistry, School of Medicine, University of Utah
Awards and Honors:
Distinguished Research Award, Ministry of Science and Technology (2021, 2012)
Dr. Cong-Ming Tu Research Award (Formosan Medical Association) (2018)
Taiwan Bio-development Foundation (TBF) Chair in Biotechnology (2015)
Tiente Lee Excellence in Medicine Technology Award (2014)
A-IMBN Research Young Investigators/Ken-ichi Arai Award (2013)
Academia Sinica Research Award for Junior Research Investigators (2012)
Dr. Chen-Yuan Lee Memorial Award for Excellence in Biomedical Research (2012)
Selected Publications:
1) Tang, H., Wu, M.-H., Lin, H.-Y., Han, M.-R., Tu, Y.-H, Yang, Z.-J., Chieh, T.-C.,* Chan, N.-L.,* and Chang, W.-C.* (2022) Mechanistic analysis of carbon-carbon bond formation by deoxypodophyllotoxin synthase. Proc. Natl. Acad. Sci. U.S.A. 119(1):e2113770119; doi: 10.1073/pnas.2113770119) (co-corresponding author)
2) Hsieh CM, Chen CY, Chern JW & Chan, N.-L.* (2020) Structure of Human Phosphodiesterase 5A1 Complexed with Avanafil Reveals Molecular Basis of Isoform Selectivity and Guide-lines for Targeting α-Helix Backbone Oxygen by Halogen Bonding. J Med Chem. 63:8485–8494. (Journal Cover)
3) Li J, Liao HJ, Tang Y, Huang JL, Cha L, Lin TS, Lee JL, Kurnikov IV, Kurnikova MG*, Chang WC*, Chan, N.-L.*, Guo Y* (2020) Epoxidation Catalyzed by the Nonheme Iron(II)- and 2-Oxoglutarate-Dependent Oxygenase, AsqJ: Mechanistic Elucidation of Oxygen Atom Transfer by a Ferryl Intermediate. J Am Chem Soc. 142:6268-6284. (Journal Cover)
4) Chen, S.-F., Huang, N.-L., Lin, J.-H., Wang, Y.-R., Wu, C.-C., Yu, Y.-J., Gilson, M.* & Chan, N.-L.* (2018) Structural Insights into the Gating of DNA Passage by the Topoisomerase II DNA-Gate. Nature Communications, 9(1):3085. doi: 10.1038/s41467-018-05406-y
5) Wang, Y.-R., Chen, S.-F., Wu, C.-C., Liao, Y.-W., Lin, T.-S., Liu, K.-T., Chen, Y.-S., Li, T.-K.*, Chien, T.-C.*, & Chan, N.-L.* (2017) Producing irreversible topoisomerase II-mediated DNA breaks by site-specific Pt(II)-methionine coordination chemistry. Nucleic Acids Res. 45:10861-10871.
Professional and Research Experience:
2019.08 ~ Present: Associate Professor, Institute of Molecular Medicine, National Tsing Hua University
2020.02 ~ Present: Honorary Professor, Mathematical Sciences, University of Liverpool
2015.02 ~ 2019.07: Assistant Professor, Institute of Molecular Medicine, National Tsing Hua University
2011.08 ~ 2015.01: Research Fellow, Department of Cell Biology, Johns Hopkins University School of Medicine
2009.07 ~ 2011.08: Postdoctoral Fellow, Institute of Molecular Medicine, National Taiwan University
Awards and Honors:
2021: Outstanding Scholar Award, Foundation for the Advancement of Outstanding Scholarship.
2021: Outstanding teaching award, National Tsing Hua University
2020: 58th Ten Outstanding Persons
2019: MOST Young Scholar Fellowship
2018: Outstanding research award for junior faculty, National Tsing Hua University
2018: 14th TienTe Lee Award
2017: Outstanding teaching award, National Tsing Hua University
Selected Publications:
Fan CH*, Wei KC, Chiu NH, Wang HC, Wu RY, Ho YJ, Chan HL, Wang TSA, Huang YZ, Hsieh TH, Lin CH, Lin YC#, Yeh CK#. (2021). “Sonogenetic based neuromodulation for the amelioration of Parkinson's disease”. Nano Letters 21(14):5967-5976
Lian YL*, Chen KW*, Chou YT, Ke TL, Chen BC, Lin YC#, Chen L#. (2020) "PIP3 depletion rescues myoblast fusion defect in human rhabdomyosarcoma cells". Journal of Cell Science 133, jcs240325
Yang WT*, Hong SR*, He K*, Ling K, Shaiv K, Hu J#, Lin YC#. (2021) "The emerging roles of axonemal glutamylation in regulation of cilia architecture and functions" Frontiers in Cell and Developmental Biology 9: 622302.
Wu CY*, Fan CH*, Chiu NH, Lin YC#, Yeh CK#. (2020) "Targeted delivery of engineered auditory sensing protein for ultrasound neuromodulation in the brain". Theranostics 10(8):3546-3561
Huang YS*, Fan CH*, Hsu N*, Chiu NH, Wu CY, Guo V, Chiang YC, Hsu WC, Chen L, Lai CPK, Yeh CK#, Lin YC#. (2020) "Sonogenetic modulation of cellular activities using an engineered auditory-sensing protein". Nano Letters 20(2):1089-1100
Hong SR*, Wang CL*, Huang YS, Chang YC, Chang YC, Pusapati GV, Lin CY, Hsu N, Cheng HC, Chiang YC, Huang WE, Shaner NC, Rohatgi R, Inoue T,# Lin YC# (2018). “Spatiotemporal manipulation of ciliary glutamylation reveals its roles in intraciliary trafficking and Hedgehog signaling”. Nature Communications 9, 1732
Fan CH*, Huang YS*, Huang WE*, Lee AA*, Ho SY, Kao YL, Wang CL, Lian YL, Ueno T, Wang TSA, Yeh CK, Lin YC# (2017) "Manipulating cellular activities using an ultrasound-chemical hybrid tool". ACS Synthetic Biology 6: 2021-2027.
Professional and Research Experience:
Postdoc, Stanford University
Research scientist, Stanford University
Awards and Honors:
Career Development Award from Academia Sinica
Special outstanding talent award from MOST (延攬特殊優秀人才)
Investigator Fellowship from Academia Sinica (新聘學術研究獎)
Novo Nordisk STAR Postdoc Fellowship
U.C. Davis Pathology Fellowship
National Taiwan University President's Award
Selected Publications:
1. Chen, S.Y., Ho, C.D., Liu, W.W., Lucanic, M., Shih, H.M., Huang, P.H., and Cheng, H.J. Regulation of Axon Repulsion by MAX-1 SUMOylation and AP-3. (2018) Proceedings of the National Academy of Sciences. 115(35): 8236-8245.
2. Lu, C.*, Chen, S.Y.*, Van Neste, C., Natkunam, Y, Gilliland, D.G., Nolan, G.P., Weissman, I.L. Wernig, G. Activation of JUN in fibroblasts promotes pro-fibrotic programme and dampens protective immunity. (2020) Nature Communications 11(1): 2795 * Co-first auther
3. Weng, R., Lu, H.H., Lin, C.T., Fan, C.C., Lin, R.S., Huang,T.C., Lin, S.Y., Huang, Y.J., Juan, Y.H., Wu,Y.C., Hung,Z.C., Liu,C., Lin, X.H., Hsieh, W.C., Chiu, T.Y., Liao, J.C., Chiu, Y.L., Chen, S.Y., Yu, C.J., Tsai, H.C. Epigenetic modulation of immune synaptic-cytoskeletal networks potentiates γδ T cell-mediated cytotoxicity in lung cancer. (2021) Nature Communications 12: 2163
4. Rovira-Clavé, X.*, Jiang, S.Z.*, Bai, Y.H., Barlow, G.L., Bhate, S., Bava, F.A., Coskun, A.F., Han, G.J., Zhu, B.K., Ho, C.M., Hitzman, C., Chen, S.Y.#, Bava, F.A. #, Nolan, G.P. # Subcellular localization of drug distribution by super-resolution ion beam imaging. (2021) Nature Communications 12: 4628. # Co-senior author
5. Hsieh, W.C., Lai, E.Y., Liu, Y.T., Wang, Y.F., Tzeng,Y.S., Cui,L., Lai, Y.J., Huang, H.C., Huang,J.H., Ni, H.C., Tsai, D.Y., Liang, J.J., Liao, C.C., Lu, Y.T., Jiang,L., Liu, M.T., Chang, Y.Y., Wernig, G., Li, C.W., Lin, K.I., Lin, Y.L., Tsai, H.K., Huang, Y.T., Chen, S.Y.# Natural killer cell receptor and ligand composition influences the clearance of SARS-CoV-2. (2021) Journal of Clinical Investigation 131(21):e146408
# Corresponding author
Professional and Research Experience:
CEO, Syncell Inc., 2021-present
Research Fellow (currently on leave), Institute of Atomic and Molecular Sciences, Academia Sinica, 2019-present
Professor (adjunct), Department of Physics, National Taiwan University, 2020-2021
Professor (adjunct), Genome and Systems Biology Degree Program, National Taiwan University, 2020-2021
Associate Research Fellow, Institute of Atomic and Molecular Sciences, Academia Sinica, 2014-2019
Associate Professor (adjunct), Genome and Systems Biology Degree Program, National Taiwan University, 2015-2019
Assistant Professor, Mechanical Engineering, Columbia University, 2008-2013
Assistant Professor (affiliated), Biomedical Engineering, Columbia University, 2009-2013
Research Associate, Bioengineering, Stanford University, 2005-2008
Postdoc Fellow, Molecular and Cell Biology, ESPM, University of California, Berkeley, 2002-2005
Awards and Honors:
Outstanding Research Award, Ministry of Science and Technology, 科技部傑出研究獎 2021
National Innovation Award, 國家新創獎2020
Academia Sinica Career Development Award 2015
Foundation for the Advancement of Outstanding Scholar Award 2014
Selected Publications:
Chong, W.M., Wang, W.-J., Lo, C.-H., Chiu, T.-Y., Chang, T.-J., Liu, Y.-P., Tanos, B., Mazo, G., Tsou, M.-F.B., Jane, W.-N., Yang, T.T.*, Liao, J.-C.* (2020) Super-resolution microscopy reveals coupling between mammalian centriole subdistal appendages and distal appendages. eLife, 9, e53580. (IF=7.080)
Yang, T.T., Tran T.M.N., Chong, W.M., Huang, C.-E., Liao, J.-C.* (2019) Single particle tracking localization microscopy reveals nonaxonemal dynamics of intraflagellar transport proteins at the base of mammalian primary cilia. Molecular Biology of the Cell, 30, 828-837. (IF=3.791)
Weng, R.R., Yang, T.T., Huang, C.-E., Chang, C.-W., Wang, W.-J., Liao, J.-C.* (2018) Super-resolution imaging reveals TCTN2 depletion-induced IFT88 lumen leakage and ciliary weakening. Biophysical Journal, 115, 263-275. (IF=3.854)
Yang, T.T., Chong, W.M., Wang, W.-J., Mazo G., Tanos, B., Chen, Z., Tran T.M.N., Chen, Y.-D., Weng, R.R., Huang, C.-E., Jane, W.-N. Tsou, M.-F.B.*, Liao, J.-C.* (2018) Super-resolution architecture of mammalian centriole distal appendages reveals distinct blade and matrix functional components. Nature Communications, 9, 2023. (IF=12.121)
Yang, T.T., Su, J., Wang, W.-J., Craige, B., Witman, G.B., Tsou, M.-F.B., Liao, J.-C.* (2015) Superresolution pattern recognition reveals architectural map of the ciliary transition zone, Scientific Reports, 5, 14096. (IF=3.998)
Professional and Research Experience:
2018/8~2021/8 Dean of Research and Development; Kaohsiung Medical University, Kaohsiung, Taiwan.
2015/08~2018/07, Vice Dean, College of Medicine, Kaohsiung Medical University (KMU) , Kaohsiung, Taiwan
2014/9~2018/07, Director of Graduate Institude of Medicine, KMU, Kaohsiung, Taiwan
2014/8~2019/07, Director, Center for Biomarkers and Biotech Drugs, KMU, Kaohsiung
2015/08~2018/07,Distinguished Professor,Department of Biomedical Science and Environmental Biology, KMU
Awards and Honors:
2014、2017 Ministry of Science and Technology, Outstanding Research Award
2019 The Future Tech Expo.(未來科技展-未來科技突破獎)
2020 Outstanding Contribution Award for Technology Transfer of the Ministry of Science and Technology(科技部技術移轉傑出貢獻獎)
2020 TECO Awards (東元獎)
2020 National Invention and Creation Award (Silver Award)國家發明創作獎(銀獎)
2021 The Future Tech Expo.(未來科技展-未來科技突破獎)
Selected Publications:
Ho KW, Chen IU, Cheng YA, Liao TY, Liu ES, Chen HJ, Lu YC, Su YC, Roffler SR, Huang BC, Liu HJ, Huang MY, Chen CY, Cheng TL*. Double attack strategy for leukemia using a pre-targeting bispecific antibody (CD20 Ab-mPEG scFv) and actively attracting PEGylated liposomal doxorubicin to enhance anti-tumor activity. J Nanobiotechnology 2021 Jan 9;19(1):16. 2020 SCI IF=10.435 (SCI, 8/159=5%) in BIOTECHNOLOGY & APPLIED MICROBIOLOGY.
Chen IJ, Cheng YA, Ho KW, Lin WW, Cheng KW, Lu YC, Hsieh YC, Huang CC, Chuang CH, Chen FM, Su YC, Roffler SR, Cheng TL. *; Bispecific Antibody (HER2 × mPEG) Enhances Anti-Cancer Effects by Precise Targeting and Accumulation of mPEGylated Liposomes. Acta Biomater. 2020 Jul 15;111:386-397. 2020 SCI IF= 8.947 (SCI, 10/90=11.1%) in ENGINEERING BIOMEDICAL.
Cheng YA, Chen IJ, Su YC, Cheng KW, Lu YC, Lin WW, Hsieh YC, Kao CH, Chen FM, Roffler SR*, Cheng TL*; Enhanced drug internalization and therapeutic efficacy of PEGylated nanoparticles by one-step formulation with anti-mPEG bispecific antibody in intrinsic drug-resistant breast cancer. Biomater Sci. 2019 Aug 1;7(8):3404-3417. 2020 IF=6.843 (8/40=20%) in MATERIALS SCIENCE, BIOMATERIALS.
Lu YC, Chuang CH, Chuang KH, Chen IJ, Huang BC, Lee WH, Wang HE, Li JJ, Cheng YA, Cheng KW, Wang JY, Hsieh YC, Lin WW*, Cheng TL*;.Specific activation of pro-Infliximab enhances selectivity and safety of rheumatoid arthritis therapy. PLoS Biol. 2019 Jun 13;17(6):e3000286. 2020 IF=8.029 (6/93=6.45%) in BIOLOGY..
Hsieh YC, Wang HE, Lin WW, Roffler SR, Cheng TC, Su YC, Li JJ, Chen CC, Huang CH, Chen BM, Wang JY, Cheng TL*, Chen FM*. Pre-existing anti-polyethylene glycol antibody reduces the therapeutic efficacy and pharmacokinetics of PEGylated liposomes. Theranostics. 2018 May 9;8(11):3164-3175. 2020 SCI IF=11.556 (SCI, 9/140=6.4%) in MEDICINE, RESEARCH & EXPERIMENTAL.
Su YC, Burnouf PA, Chuang KH, Chen BM, Cheng TL*, Roffler SR*. Conditional internalization of PEGylated nanomedicines by PEG engagers for triple negative breast cancer therapy. Nat Commun. 2017 Jun 8;8:15507. 2020 SCI IF=14.919 (SCI, 4/73=5.4%) in MULTIDISCIPLINARY SCIENCES.
Professional and Research Experience:
The biochemical and molecular mechanisms of T cell activation, differentiation, and tolerance, which could help reach immune tolerance in autoimmune disease and transplantation. Current project focus on metabolic cues such as HIF-1 α and glutamine. We are also interested in microRNA and epigenetic regulation in immune system.
Awards and Honors:
Outstanding Research Scholar Award, 2018 (中華免疫學會傑出研究學者獎)
Wan-Yu Chen Award, 2017 (台灣腎臟醫學會陳萬裕研究獎)
AAI Early Career Faculty Travel Award, 2017
Selected Publications:
Yang HY, Dang EV, Barbi J, Jinasena D, Yu H, Zheng Y, Bordman Z, Fu J, Kim Y, Yen HR, Luo W, Zeller K, Shimoda L, Topalian SL, Semenza GL, Dang CV, Pardoll DM*, Pan F*.Control of T(H)17/T(reg) Balance by Hypoxia-Inducible Factor 1. Cell. 2011; 146(5): 772-784.
Yang HY, Barbi J, Wu CY, Zheng Y, Vignali P D.A., Wu X, Tao JH, Park BV, Bandara S, Novack L, Ni X, Yang X, Chang KY, Wu RC, Zhang J, Yang CW, Pardoll DM, Li HB, Pan F*. The MicroRNA miR-17 modulates regulatory T cell activity by targeting Foxp3 Co-regulators. Immunity. 2016 Jul; 45(1): 83-93
Yen CL, Wu CY, See LC, Li YJ, Tseng MH, Peng WS, Liu JR, Chen YC, Yen TH, Tian YC, Yang CW, Gerard F. Anderson, Yang HY*. Pioglitazone Reduces Mortality and Adverse Events in Patients With Type 2 Diabetes and With Advanced Chronic Kidney Disease: National Cohort Study. Diabetes Care. 2020 Oct; 43:e152–e153
Tsai CY, Chi HC, Wu RC, Weng CH, Tai TS, Lin CY, Chen TD, Wang YH, Chou LF, Hsu SH, Lin PH, Pang ST, Yang HY*. Combination Biomarker of Immune Checkpoints Predict Prognosis of Urothelial Carcinoma. Biomedicines. 2022, 10(1), 8.
Professional and Research Experience:
2021- Associate investigator, Institute of Molecular and Genomic Medicine,
NHRI
2017- Adjunct assistant professor, Graduate Institute of Clinical Medicine,
National Taiwan University, TAIWAN
2013-2020 Assistant investigator, Institute of Molecular and Genomic Medicine,
NHRI
2008-2013 Postdoctoral fellow, Institute of Molecular Medicine and Experimental
Immunology, University of Bonn, Germany
2007-2008 Postdoctoral fellow, Graduate Institute of Clinical Medicine, National
Taiwan University, TAIWAN
Awards and Honors:
2018 Gilead Sciences Research Scholars Program in Liver Disease-Asia
2004-2012 Travel grant awards, International Meeting on the Molecular Biology of
Hepatitis B Viruses
2011 BONFOR research prize, Research Commission of Medical School of
University of Bonn, Germany
2007 Award for excellent Ph.D thesis, Liver Disease Prevention &Treatment
Research Foundation
2007 The 17th Annual Wang Ming-Ning Award for medical Ph.D thesis
1998 Shen Fong-Wen Award for excellent master student
Selected Publications:
Knolle, P.A., Huang, L.R., Kosinska, A., Wohlleber, D., Protzer, U. Improving Therapeutic Vaccination against Hepatitis B-Insights from Preclinical Models of Immune Therapy against Persistent Hepatitis B Virus Infection. Vaccines (Basel). 2021 Nov 16;9(11):1333. doi: 10.3390/vaccines9111333.
Liu, Y.T.§, Tseng, T.C. §, Soong, R.S. §, Peng, C.Y., Cheng, Y.H., Huang, S.F., Chuang, T.H., Kao, J.H. Liu, Y.T.§, Tseng, T.C. §, Soong, R.S. §, Peng, C.Y., Cheng, Y.H., Huang, S.F., Chuang, T.H., Kao, J.H. and Huang, L.R.* A novel spontaneous hepatocellular carcinoma mouse model for studying T-cell exhaustion in the tumor microenvironment. J Immunother Cancer. 2018 Dec 7;6(1):144. doi: 10.1186/s40425-018-0462-3. *Corresponding author.
Hsu, W.C., Chen, M.Y., Hsu, S.C., Huang, L.R., Kao, C.Y., Cheng, W.H., Pan, C.H., Wu, M.S., Yu, G.Y., Hung, M.S., Leu, C.M., Tan, T.H., Su, Y.W. DUSP6 mediates T cell receptor-engaged glycolysis and retains TFH cell differentiation. Proc Natl Acad Sci U S A. 2018 Aug 21;115(34):E8027-E8036. doi: 10.1073/pnas.1800076115.
Lu, C.H., Yeh, D.W., Lai, C.Y., Liu, Y.L., Huang, L.R., Lee, A.Y., Jin, S.C., Chuang, T.H. USP17 mediates macrophage-promoted inflammation and stemness in lung cancer cells by regulating TRAF2/TRAF3 complex formation. Oncogene. 2018 Dec;37(49):6327-6340. doi: 10.1038/s41388-018-0411-0.
Tseng, T.C., Huang, L.R.* Immunopathogenesis of hepatitis B virus. The Journal of Infectious Diseases, 2017;216(S8):S765-70 Review article. *Corresponding author.
Jian, S.L., Chen, W.W., Su, Y.C., Su, Y.W., Chuang, T.H., Hsu, S.C. and Huang, L.R.* Glycolysis regulates the expansion of myeloid-derived suppressor cells in tumor-bearing hosts through prevention of ROS-mediated apoptosis. Cell Death & Disease, 2017, 8, e2779; doi:10.1038/cddis.2017.192. *Corresponding author.
Professional and Research Experience:
Postdoctoral fellow, Department of Molecular and Cell Biology, University of California, Berkeley, USA
Awards and Honors:
Damon Runyon Cancer Research Foundation postdoctoral fellowship
Selected Publications:
Huang RS, Lai MC, Shih HA, Lin S. (2021) A robust, integrated platform for expansion and CRISPR-Cas9 genome editing of primary human natural killer cells. J Exp Med, 218(3), e20201529.
Huang KY, Lin MS, Kuo TC, Chen CL, Lin CC, Chou YC, Chao TL, Pang YH, Ka HC, Huang RS, Lin S, Chang SY, Yang PC. (2021) Humanized COVID-19 decoy antibody effectively blocks viral entry and prevents SARS-CoV-2 infection. EMBO Mol Med, 13(1), e12828.
Huang RS, Shih HA, Lai MC, Chang YJ and Lin S. (2020) Enhanced NK-92 Cytotoxicity by CRISPR Genome Engineering Using Cas9 Ribonucleoproteins. Front Immunol, 11:1008.
Professional and Research Experience:
Dr. Lee has been interested in investigating the biological roles of type I interferon (IFN-I) and its downstream signal mediators, signal transducers and activators of transcription (STAT) family members, particularly STAT1 and STAT3, in cytokine signaling and immune modulation for over two decades. He has made several seminal findings, including a synergism of IFN-I and Flt3L in dendritic cell development, an essential role of STAT1 in marginal zone B differentiation and versatile functions of STAT3 in B lymphopoiesis and granulopoiesis, and IFN-I-dependent antiviral activity. His current research directions include 1) Cooperation between DCs and B cells in promoting TI response, 2) Regulation of DC development and functions during inflammation, and 3) Fine-tuning of IFN-I-dependent antiviral and inflammatory response by STAT3.
Awards and Honors:
Dr. Lee has received numerous awards including YZ Hsu Scientific Paper Award 有庠科技論文獎 (2014), The outstanding research award (three-time grant awardee) from NHRI (2016) and Tsungming Tu Memorial Lecture Award 杜聰明博士紀念演講獎 (2017) The Outstanding Research Scholar of the Chinese Society of Immunology (2018). He also serves as a guest editor and editorial reviewer of Frontiers in Immunology, and ad hoc reviewers of several journals, including PNAS, Blood, Oncoimmunology, Stem Cells, Scientific Reports...etc. Currently he is an Associate Editor of Frontiers in Immunology.
Selected Publications:
Chien-Kuo Lee and Hans A. R. Bluyssen Editorial: STATs and IRFs in Innate Immunity: From Transcriptional Regulators to Therapeutic Targets 2019 10:1829
Ting-Ting Chen, Ming-Hsun Tsai, John Kung, Thomas Decker, Kuo-I Lin and Chien-Kuo Lee STAT1 regulates marginal zone B cell differentiation in response to inflammation and infection with blood-borne bacteria. J. Exp. Med. 2016 213:3025
Yi-Ling Chen, Ting-Ting Chen, Li-Mei Pai, Joanna Wesoly, H. A. R. Bluyssen and Chien-Kuo Lee A type I IFN/Flt3 ligand axis augments plasmacytoid dendritic cell development from common lymphoid progenitors. J. Exp. Med. 2013 210:2515
Professional and Research Experience:
2018-Present:
Assistant Professor of Immunology
Department of Pathology, Case Western Reserve University School of Medicine, USA
2018-Present:
Member, Case Comprehensive Cancer Center, USA
2011-2018:
Postdoctoral Research Associate
Department of Pathology & Immunology
Washington University School of Medicine, USA
Advisor: Professor Marco Colonna & Professor Edward J. Pearce
Awards and Honors:
2022 Andrew McDonough B+ Foundation Childhood Cancer Research Grant Award
2020 Case Comprehensive Cancer Center GI SPORE Developmental Research
Project Pilot Award
2020 VeloSano Bike to Cure Pilot Award
2019 Cancer Research Institute CLIP Investigator Award
2019 Case Comprehensive Cancer Center ACS IRG Early Career Pilot Award
2019 Cleveland Digestive Diseases Research Core Center Pilot Award
2018 Case Comprehensive Cancer Center ACS IRG Pilot Award
Selected Publications:
Raines LN, Zhao H, Wang Y, Chen HY, Gallart-Ayala H, Hsueh PC, Cao W, Koh Y, Alamonte-Loya A, Liu PS, Ivanisevic J, Lio CWJ, Ho PC, Huang SC*, PERK is a critical metabolic hub for immunosuppressive function in macrophages. Nature Immunology, 2022 (In press).
Lio CJ, Huang SC*, Circles of life: linking metabolic and epigenetic cycles to immunity. Immunology, 2020; 161(3):165-174 [PMID: 32418209]
Di Luccia B, Gilfillan S, Cella M, Colonna M, Huang SC*. ILC3s integrate glycolysis and mitochondrial production of reactive oxygen species to fulfill activation demands. Journal of Experimental Medicine, 2019; 216(10):2231-2241. [PMID: 31296736]
Huang SC, Smith AM, Everts B, Colonna M, Pearce EL, Schilling JD, Pearce EJ. Metabolic reprogramming mediated by the mTORC2-IRF4 axis is essential for macrophage alternative activation. Immunity, 2016; 45(4): 817-830. [PMID: 27760338]
Huang SC, Everts B, Ivanova Y, O’Sullivan D, Nascimento M, Smith AM, Beatty W, Love-Gregory L, Lam WY, O’Neill CM, Yan C, Du H, Abumrad NA, Urban JF Jr, Artyomov MN, Pearce EL, Pearce EJ. Cell-intrinsic lysosomal lipolysis is essential for alternative activation of macrophages. Nature Immunology, 2014; 15(9): 846-855. [PMID: 25086775]
Professional and Research Experience:
2021 – present: Associate Professor, Institute of Microbiology and Immunology, National Yang-Ming Chiao-Tung University, Taipei, Taiwan
2013 – 2021: Assistant Professor, Institute of Microbiology and Immunology, National Yang-Ming Chiao-Tung University, Taipei, Taiwan
Awards and Honors:
2015 – Outstanding poster award at the Glycoscience Symposium, Academia Sinica, Taipei, Taiwan
2010 – 2012: Irvington Institute postdoctoral fellowship of the Cancer Research Institute
Selected Publications:
Hsu HP, Chen YT, Chen YY, Lin CY, Chen PY, Liao SY, Lim CCY, Yamaguchi Y, Hsu CL, Dzhagalov IL; Heparan sulfate is essential for thymus growth. J Biol Chem. 2021 Feb 15:100419. doi: 10.1016/j.jbc.2021.100419.
Chu CF, Feng HK, Sun KH, Hsu CL, Dzhagalov IL; Examination of Fas-Induced Apoptosis of Murine Thymocytes in Thymic Tissue Slices Reveals That Fas Is Dispensable for Negative Selection. Front. Cell Dev. Biol. 8:586807. doi: 10.3389/fcell.2020.586807
Zhou TA, Hsu CL, Dzhagalov IL. Testing the Efficiency and Kinetics of Negative Selection Using Thymic Slices. Methods Mol Biol. 2020;2111:205-219. doi: 10.1007/978-1-0716-0266-9_17.
Kurd NS, Lutes LK, Yoon J, Chan SW, Dzhagalov IL, Hoover AR, Robey EA. A role for phagocytosis in inducing cell death during thymocyte negative selection. Elife. 2019 Dec 23;8. pii: e48097
Hsu C-L, Dzhagalov IL. Metabolite Transporters—The Gatekeepers for T Cell Metabolism. Immunometabolism. 2019;1:e190012. https://doi.org/10.20900/immunometab20190012
Chen ST, Chen L, Lin DS, Chen SY, Tsao YP, Guo H, Li FJ, Tseng WT, Tam JW, Chao CW, Brickey WJ, Dzhagalov I, Song MJ, Kang HR, Jung JU, Ting JP. NLRP12 Regulates Anti-viral RIG-I Activation via Interaction with TRIM25. Cell Host Microbe. 2019 Apr 10;25(4):602-616.e7. doi: 10.1016/j.chom.2019.02.013. Epub 2019 Mar 19.
Wei CW, Lee CY, Lee DJ, Chu CF, Wang JC, Wang TC, Jane WN, Chang ZF, Leu CM, Dzhagalov IL, Hsu CL. Equilibrative Nucleoside Transporter 3 Regulates T Cell Homeostasis by Coordinating Lysosomal Function with Nucleoside Availability. Cell Rep. 2018 May 22; 23(8):2330-2341. doi: 10.1016/j.celrep.2018.04.077.
Dzhagalov IL, Chen KG, Herzmark P, Robey EA. Elimination of Self-Reactive T cells in the Thymus: A Timeline of Negative Selection. PLoS Biol. 2013 May;11(5):e1001566. doi: 10.1371/journal.pbio.1001566. Epub 2013 May 21.
Dzhagalov IL, Melichar HJ, Ross JO, Herzmark P, Robey EA. Two-photon imaging of the immune system. Current Protocols in Cytometry 2012 Apr;Chapter 12:Unit12.26.
Dzhagalov I and Phee H. How to find your way through the thymus: a practical guide for aspiring T cells, Cell Mol Life Sci 2012 Mar;69(5):663-82
Dzhagalov I and Robey EA. Multitasking in the medulla, Nat Immunol 2010 May 11:461-462
Phee H, Dzhagalov I, Mollenauer M, Wang Y, Irvine DJ, Robey E, Weiss A. Regulation of thymocyte positive selection and motility by GIT2, Nat Immunol 2010 May 11:503-511
Le Borgne M, Ladi E, Dzhagalov I, Herzmark, P, Liao YF, Chakraborty AK, Robey, EA. The impact of negative section on thymocyte migration in the medulla, Nat Immunol 2009 Aug:10(8):823-30
Dzhagalov I, Dunkle A, He YW. The anti-apoptotic Bcl-2 family member Mcl-1 promotes T lymphocyte survival at multiple stages, J Immunol 2008 Jul:181(1):521-8
Dzhagalov I, Chambon P, He YW. Regulation of CD8+ T Lymphocyte Effector Function and Macrophage Inflammatory Cytokine Production by Retinoic Acid Receptor Gamma, J Immunol 2007 Feb:178(4):2113-2121
Dzhagalov I, St John A, He YW. The Anti-apoptotic protein Mcl-1 is essential for the survival of neutrophils but not macrophages. Blood. 2007 Feb; 109(4):1620-1626.
Professional and Research Experience:
2017.02 - 2019.07, Vice Dean, College of Medicine, National Cheng Kung University
2012.08 - 2015.07, Chairman, Department of Cell Biology and Anatomy, College of Medicine, National Cheng Kung University
2005.08 - 2008.07, Director, Teaching Resource Center, College of Medicine, National Cheng Kung University
Awards and Honors:
2008 Best Teaching Award, College of Medicine, National Cheng Kung University
Selected Publications:
Wang TF, Tsai SF, Zhao ZW, Kuo YM*. Exercise-induced increase of corticosterone participates in exercise-enhanced adult hippocampal neurogenesis in mice. Chin J Physiol 64:186-193 (2021)
Lkhagvasuren B, Mee-inta O, Zhao ZW, Hiramoto T, Boldbaatar D, Kuo YM*. Pancreas-brain crosstalk. Front Neuroanat 15: 691777 (2021)
Wu SY, Pan BS, Tsai SF, Chiang YT, Huang BM, Mo FE, Kuo YM*. BDNF reverses aging-related microglial activation. J Neuroinflammation 17: 210 (2020)
Tsai SF, Liu YW, Kuo YM*. Acute and long-term treadmill running differentially induce c-Fos expression in regions- and time-dependent manners in mouse brain. Brain Struct Funct 224: 2677-2689 (2019)
Beh ST, Kuo YM*, Chang WS, Wilder-Smith E, Tsao CH, Tsai CH, Chen LT, Liao LD*. Preventive hypothermia as a neuroprotective strategy for paclitaxel-induced peripheral neuropathy. Pain 160: 1505-1521 (2019)
Tsai SF, Wu HT, Chen PC, Chen YW, Yu M, Wang TF, Wu SY, Tzeng SF, Kuo YM*. High-fat diet suppresses the astrocytic process arborization and downregulates the glial glutamate transporters in the hippocampus of mice. Brain Res 1700: 66-77 (2018).
Tsai SF, Wu HT, Chen PC, Chen YW, Yu M, Tzeng SF, Wu PH, Chen PS, Kuo YM*. Stress aggravates high-fat diet-induced insulin resistance via a mechanism that involves the amygdala and is associated with changes in neuroplasticity. Neuroendocrinology 107: 147-157 (2018)
Tsai SF, Ku NW, Wang TF, Yang YH, Shih YH, Wu SY, Lee CW, Yu M, Yang TT, Kuo YM*. Long-term moderate exercise rescues age-related decline in hippocampal neuronal complexity and memory. Gerontology 64:551-561 (2018)
Shih YH, Wu SY, Yu M, Huang SH, Lee CW, Jiang MJ, Lin PY, Yang TT, Kuo YM*. Hypertension accelerates Alzheimer’s disease-related pathologies in pigs and 3xTg mice. Front Aging Neurosci 10:73 (2018).
Professional and Research Experience:
Assistant Professor, Department of Physiology, College of Medicine, National Cheng Kung University, Taiwan
Visiting Associate, Division of Biology and Biological Engineering, California Institute of Technology, USA
Postdoctoral Scholar, Division of Biology and Biological Engineering, California Institute of Technology, USA
Postdoctoral Fellow, Institute of Biomedical Sciences, Academia Sinica, Taiwan
Research Assistant, Division of Metabolism, Department of Internal Medicine, Chang-Gung Memorial Hospital, Taiwan
Awards and Honors:
2021.08 MOST Research Grants (Rewarding Outstanding Talent and Recruiting of Outstanding Talent) and Research Merit Pay for School Faculty and Researchers
2021.09 Outstanding research, National Cheng Kung University
2021.06 Outstanding research, College of Medicine, National Cheng Kung University
2021.05 Excellence in Teaching, Department of Physiology, College of Medicine, National Cheng Kung University
2020.08 MOST Research Grants (Rewarding Outstanding Talent and Recruiting of Outstanding Talent) and Research Merit Pay for School Faculty and Researchers
2019.08 MOST Research Grants (Rewarding Outstanding Talent and Recruiting of Outstanding Talent) and Research Merit Pay for School Faculty and Researchers
2018.08 MOST Research Grants (Rewarding Outstanding Talent and Recruiting of Outstanding Talent) and Research Merit Pay for School Faculty and Researchers
2012.07 Best Poster Presentation Award, National Institutes of Health (NIH) Silvio O. Conte Centers for Basic and Translational Mental Health Retreat, Denver, CO, USA
2011.12 Postdoctoral Scholar Fellowship. Postdoctoral Research Abroad Program sponsored by National Science Council, Taiwan
Selected Publications:
Wu, W.L.*, Adame, M.D., Liou, C.W., Barlow, C.W., Lai, T.T., Sharon G., Schretter, C.E., Needham, B.D., Wang, M., Tang, W., Ousey, J., Lin, Y.Y., Yao, Z.H., Abdel-Haq, R., Beadle, K., Gradinaru, V., Ismagilov, R.F., Mazmanian, S.K., 2021. Microbiota regulate social behaviour via stress response neurons in the brain. Nature, 595, 409-414.
Needham, B.D., Tang, W., Wu, W.L.*, 2017. Searching for the gut microbial contributing factors to social behavior in rodent models of autism spectrum disorder. Developmental Neurobiology, 78, 474-499.
Wu, W.L.*, 2017. Association among gut microbes, intestinal physiology, and autism. EBioMedicine, 25. 11-12.
Professional and Research Experience:
2009-current Investigator; Institute of Molecular and Genomic Medicine, NHRI
2018-2020 Associate Director, IMGM, NHRI
2009-current Joint Appointment Associate Professor, Graduate Institute of Basic Medical Science, China Medical University
2011-current Adjunct Professor, Institute of Molecular & Cellular Biology, NTU
2012-current Joint Appointment Associate Professor; Graduate Institute of Life Sciences, National Defense Medical Center
2004-2009 Associate investigator; Division of Molecular and Genomic Medicine, NHRI
1997-2012 Adjunct Associate Professor; Graduate Institute of Life Sciences, National Defense Medical Center
1997-2004 Assistant investigator; Division of Molecular and Genomic Medicine, NHRI
1993-1997 Research Associate; McArdle Laboratory for Cancer Research, U.S.A.
Awards and Honors:
1. Sigma Xi Best Ph.D. Thesis Award (1993)
2. NHRI Outstanding Research Achievement Award (2013)
Selected Publications:
RH Lai, YY Hsu, CC Hsu , FS Shie , BH Yu, YK Chang, MH Chen and JL Juang*. (2021) Non-genomic rewiring of vitamin D receptor to p53 as a key to Alzheimer’s disease. Aging Cell. DOI: 10.1111/acel.13509 (published online) (IF: 9.304).
Te-Haw Wu,† Rai-Hua Lai, ‡ Chun-Nien Yao,† Jyh-Lyh Juang* (co-corresponding author), and Shu-Yi Lin,* (2021) A supramolecular bait to trigger non-equilibrium co-assembly and clearance of Aβ42. Angewandte Chemie. 60(8):4014-4017. (IF:15.336)
Wu SC, Cao ZS, Chang KM, Juang JL*. (2017) Intestinal microbial dysbiosis aggravates the progression of Alzheimer’s disease in Drosophila. Nature Comm. 8(1):24. doi:10.1038/s41467-017-00040-6 (IF: 12.12)
Wu SC, Liao CW, Pan RL, Juang JL*. (2012) Infection-induced intestinal oxidative stress triggers organ-to-organ immunological communication in Drosophila. Cell Host & Microbe. 11(4): 410–417. (featured by Cell Host & Microbe. 11: 323-324) (IF: 13.728)
Professional and Research Experience:
2018/8/1~ Associate Professor at the department of physiology in National Cheng Kung University
2014~2018/7/30 Assistant Professor at the department of physiology in National Cheng Kung University
2009- 2014 Postdoctoral Fellow, Oregon Health and Science University, Department of Biochemistry and Molecular Biology.
2007-2009 Postdoctoral Fellow, University of Wisconsin-Madison, School of Pharmacy.
2006-2007 Postdoctoral Fellow, University of Chicago, Department of human genetics
Awards and Honors:
2014-2021 The Directions Governing Research Reward Subsidies for Colleges and Universities stipulated by the Ministry of Science and Technology (MOST)
2014-2017 Youth Research Grant from Ministry of Science and Technology
2013 Travel Award for Postdoctoral fellows from American society of Biochemistry and Molecular Biology (ASBMB)
2013 The ASBMB Thematic Best Poster Award
2011-2012 Post-doctoral Trainee, National Institute of Diabetic and Digestive and Kidney Diseases, Center Training Grant T32 DK007680
2010 Tartar Award, Oregon Health and Science University
Selected Publications:
Y.Y. Kuo, J.K. Lin, Y.T. Lin, J.C. Chen, Y.M. Kuo, P.S. Chen, S.N. Wu, P.C. Chen (2020). Glibenclamide restores dopaminergic reward circuitry in obese mice through interscauplar brown adipose tissue. Psychoneuroendocrinology, 118:104712.
Y.Y. Kuo, Y.C. Lin, M. J. Calkins, P.C. Chen (2020). Endonuclease VIII-like 1 deficiency impairs survival of newly generated hippocampal neurons and memory performance in young-adult male mice. Life Sciences, 254:117755.
J.S. Ruan, J.K. Lin, Y.Y. Kuao, Y.W. Chen, P.C. Chen (2018). Chronic palmitic acid-induced lipotoxicity correlates with defective trafficking of ATP sensitive potassium channels in pancreatic beta cells. Journal of Nutritional Biochemistry, 59:37-48.
P.C. Chen, J.S. Ruan, S.N. Wu (2018). Evidence of Decreased Activity in Intermediate-Conductance Calcium-Activated Potassium Channels During Retinoic Acid-Induced Differentiation in Motor Neuron-Like NSC-34 Cells. Cell Physiology and Biochemistry, 48(6):2374-2388.
S.F. Tsai, H.T. Wu, P.C. Chen, Y.W Chen., Yu M, T.F. Wang, S.Y. Wu, S.F. Tzeng, Y.M. Kuo (2018) High-fat diet suppresses the astrocytic process arborization and downregulates the glial glutamate transporters in the hippocampus of mice. Brain Res. 1700:66-77.
S.F. Tsai, H.T. Wu, P.C. Chen, Y.W. Chen, M.Yu, S.F. Tzeng, P.H. Wu, P.S. Chen, Y.M. Kuo (2018). Stress Aggravates High-Fat-Diet-Induced Insulin Resistance via a Mechanism That Involves the Amygdala and Is Associated with Changes in Neuroplasticity. Neuroendocrinology, 107(2):147-157.
R.Y. Chao, C.H. Cheng, S.N. Wu, P.C. Chen (2018). Defective trafficking of Kv2.1 channels in MPTP-induced nigrostriatal degeneration. Journal of Neurochemistry, 144 (4): 483-497.
Y. Wu, D.A. Fortin, V.A. Cochrane, *P.C. Chen, *S.L. Shyng (2017, Sep). NMDA receptors mediate leptin signaling and regulate potassium channel trafficking in pancreatic β-cells.. Journal of Biological Chemistry, 292(37):15512-15524.
K.M. Hung, P.C. Chen, H.C. Hsieh, M. J. Calkins (2017, Feb). Mitochondrial defects arise from nucleoside/nucleotide reverse transcriptase inhibitors in neurons: Potential contribution to HIV-associated neurocognitive disorders. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 1863(2), p406-413.
S.F. Tsai, P.C. Chen, M. J. Calkins, S.Y. Wu and Y.M. Kuo (2016). Exercise Counteracts Aging-Related Memory Impairment: A Potential Role for the Astrocytic Metabolic Shuttle. Front. Aging Neurosci., 8:57.
Professional and Research Experience:
2001. 07 – 2003. 07 Medical Officer of Chinese Army, Chinese Army, Ministry of National Defense
2003. 08 – 2004. 08 Research Assistance, Institute of Biomedical Science, Chang Gung University
P.I.: Dr. Yu-Sun Chang (Distinguish Professor)
2010. 06 – 2011. 12 Post-Doctoral Research Fellow. Institute of Biomedical Science, Academia Sinica
P.I.: Dr. Yi-Shuian Huang (Research Fellow)
2011. 12 – 2013. 11 JSPS Post-Doctoral Research Fellow. Department of System Biology, Graduate school of Pharmaceutical Science, Kyoto University
P.I.: Dr. Hitoshi Okamura (Professor)
2013. 12 – 2014. 11 Takeda Science Foundation Research Fellow. Department of System Biology, Graduate school of Pharmaceutical Science, Kyoto University
P.I.: Dr. Hitoshi Okamura (Professor)
2014. 12 – 2015. 08 Kobayashi International Scholarship Foundation Researcher. Department of System Biology, Graduate school of Pharmaceutical Science, Kyoto University
P.I.: Dr. Hitoshi Okamura (Professor)
2015. 01 – 2015. 08 Core Research for Evolutional Science and Technology Researcher. Department of System Biology, Graduate school of Pharmaceutical Science, Kyoto University
P.I.: Dr. Hitoshi Okamura (Professor), retired in 2018.
2015. 09 – 2016. 11 Post-Doctoral Research Fellow. Institute of Biomedical Science, Academia Sinica
P.I.: Dr. Yi-Shuian Huang (Research Fellow)
2016. 12 – 2021. 01 Assistant Professor. Department of Physiology, School of Medicine, Taipei Medical University.
2021. 02 – present Associate Professor. Department of Physiology, School of Medicine, Taipei Medical University.
Awards and Honors:
PhD. Student Period
2008 Poster Session Award, the 9th Developmental Biology Retreat, Institute of Molecular Biology, Academia Sinica
2008 First Award of Poster Session, Annual Meeting of Neuroscience Society of Taiwan
2008 Poster Session Award, the 8th Student Thesis Workshop of the Graduate Institute of Life Sciences, National Defense Medical Center
2009 The 4th Tien-Te Lee Award-Distinguished Thesis, TienTe Lee Biomedical Foundation
2009 Third Prize of Poster Session Award, Symposium on Frontiers in Neuroscience, ION-NPAS-HKUST-NIMH Joint Meeting, Shanghai, China
Postdoctoral Fellow Period
2011 JSPS Postdoctoral Fellow Scholarship for Overseas Researchers, Japan
2013 Takeda Science Foundation Postdoctoral Fellow Scholarship, Japan
2014 Kobayashi International Scholarship Foundation Researcher, Japan
2015 Core Research for Evolutional Science and Technology (CREST) Researcher, Japan
Faculty in TMU Period
2021 Outstanding Research Award, Taipei Medical University
2021 Candidate of EMBO Global Investigator Network (waiting for interview on 24 Nov.)
Selected Publications:
PhD. Student Period (2004-2010)
1. H.-W. Chao, C.-J. Hong, T.-N. Huang, Y.-L. Lin, and Y.-P. Hsueh, SUMOylation of the MAGUK protein CASK regulates dendritic spinogenesi. Journal of Cell Biology, (2008) 182, p141-155.
# Highlighted by Faculty 1000, THE MUST BE READ ARTICLE.
2. H.-F. Wang¥, Y.-T. Shih¥, C.-Y. Chen¥, H.-W. Chao, M.-J. Lee, and Y.-P. Hsueh, Valosin-containing protein and neurofibromin interact to regulate dendritic spine density. Journal of Clinical Investigation, (2011) 121: p4820-4837. (¥ Equal contribution)
# Highlighted by a commentary in the same issue of JCI.
Postdoctoral Fellow Period (2010-2016)
3. H.-W. Chao, Y.-T. Lai, Y.-L. Lu, C. Lin, W. Mai and Y.-S. Huang, NMDAR signaling facilitates the IPO5-mediated nuclear import of CPEB3. Nucleic Acids Research, (2012) 40: p8484-98
4. H.-W. Chao, L.-Y Tsai, Y.-L. Lu, P.-Y. Lin, W.-H. Huang, H.-J Chou, W.-H. Lu, H.-C. Lin, P.-T. Lee and Y.-S. Huang, Deletion of CPEB3 Enhances Hippocampus-Dependent Memory via Increasing Expressions of PSD95 and NMDA Receptors., Journal of Neuroscience, (2013) 33 (43), p17008-17022.
# Highlighted by cover art of JN and featured by BrainFacts.org.
5. W.-H. Huang¥, H.-W. Chao¥, W.-H. Lu, and Y.-S. Huang, Elevated activation of CaMKIIa in the CPEB3-knockout hippocampus impairs a specific form of NMDAR-dependent synaptic depotentiation. Frontiers in Cellular Neuroscience, (2014) 8: e367 (¥, equal contribution)
6. M. Doi, I. Murai, S. Kunisue, G. Setsu, N. Uchio, R. Tanaka, S. Kobayashi, H. Shimatani, H. Hayashi, H.-W. Chao, Y. Nakagawa, Y. Hotta, Y. Takahashi, J. Yasunaga, M. Matsuoka, M. Hastings, H. Kiyonari, and H. Okamura, Gpr176 is a Gz-linked orphan G-protein coupled receptor that sets the pace of circadian behavior. Nature Communication, 2016 Feb 17;7:10583. doi: 10.1038/ncomms10583
Assistant Professor Period (2017-2021)
7. C.-S. Tseng, H.-W. Chao, H.-S. Huang and Y.-S. Huang*, Olfactory Experience- and Developmental Stage-Dependent Control of CPEB4 Regulates c-Fos mRNA Translation for Granule Cell Survival. Cell Reports, 2017 Nov 21;21(8):2264-2276.
8. H.-W. Chao, M. Doi, J.-M. Fustin, H. Chen, Y. Maeda, H. Hayashi, R. Tanaka, M. Sugawa, N. Mizukuchi, Y. Yamaguchi, J. Yasunaga, M. Matsuoka, M. Sakai, M. Matsumoto, S. Hamada, H Okamura*, Circadian Clock Regulates Hepatic Polyploidy by Modulating Mkp1-ERk1/2 Signalling Pathway. Nature Communication, 2017 Dec 21;8(1):2238. doi: 10.1038/s41467-017-02207-7.
9. H.-Y. Liu, C.-Y. Chen, Y.-F. Hung, H.-R. Lin, H.-W. Chao, P.-Y. Shih, C.-N. Chuang, W.-P. Li, T.-N. Huang and Y.-P. Hsueh*, RNase A Promotes Proliferation of Neuronal Progenitor Cells via an ERK-Dependent Pathway. Frontiors in Molecule Neuroscience, 2018 Nov 26;11:428. doi: 10.3389/fnmol.2018.00428. eCollection 2018.
10. Y.-T. Lai¥, H.-W. Chao¥, A. C.-Y. Lai, S.-H. Lin, Y.-J. Chang, and Y.-S. Huang, CPEB2-activated PDGFRα mRNA translation is essential for myofibroblast proliferation and pulmonary alveologenesis., Journal of Biomedical Science, 2020 Apr 15;27(1):52. doi: 10.1186/s12929-020-00643-0., (¥ Equal contribution)
11. Y.-S. Huang, K.-C. Lu, H.-W. Chao, A. Chen, T.-K. Chao, C.-Y. Guo, H.-Y. Hsieh, H.-M. Shih, H.-K. Sytwu, C.-C. Wu, The MTNR1A mRNA is stabilized by the cytoplasmic hnRNPL in renal tubular cells. Journal of Cellular Physiology., (2020), doi:10.1002/jcp.29988
12. H. Lin, Y.-S. Huang, J.-M. Fustin, M. Doi, H. Chen, H.-H. Lai, S.-H. Lin, Y.-L. Lee, P.-C. King, H.-S. Hou, H.-W. Chen, P.-Y. Young, and H.-W. Chao*, Hyperpolyploidization of hepatocyte initiates preneoplastic lesion formation in the liver. Nature Communications, (2021), 12(1):645. doi: 10.1038/s41467-020-20572-8. (*, Co-corresponding)
# Featured in a Nature Communications Editors’ Highlights webpage “Cancer”.
# Commented by Nature Communications, entitled "Ploidy dynamics increase the risk of liver cancer initiation".
# Recommended by Faculty Opinions as Very Good article.
Associate Professor Period (2021-)
13. W.-H. Lu¥, H.-W. Chao¥, P.-Y. Lin, S.-H. Lin, T.-H. Liu, and Y.-S. Huang. CPEB3-dowregulated Nr3c1 mRNA translation confers resilience to developing posttraumatic stress disorder-like behavior in fear-conditioned mice. Neuropsychopharmacology , (2021) (¥ Equal contribution)
14. Y. Xiao, L. Zhao, W. Li, X. Wang, T. Ma, L. Yang, L. Gao, C. Li, M. Zhang, D. Yang, J. Zhang, H. Jiang, H. Zhao, Y. Wang, H.-W. Chao, A. Wang, Y. Jin, H. Chen, Circadian clock gene BMAL1 controls testosterone production by regulating steroidogenesis‐related gene transcription in goat Leydig cells. Journal of Cellular Physiology, 2021 Feb 17, doi: 10.1002/jcp.30334
15. L. Zhao, L. Yang, J. Zhang, Y. Xiao, M. Wu, T. Ma, X. Wang, L. Zhang, H. Jiang, H.-W. Chao, A. Wang, Y. Jin, H. Chen, Bmal1 promotes prostaglandin E2 synthesis by upregulating Ptgs2 transcription in response to increasing estradiol levels in day 4 pregnant mice. American journal of physiology-endocrinology and metabolism, 2021 Apr 07, 320(4), doi:10.1152/ajpendo.00466.2020
16. L. Yang, T. Ma, L. Zhao, H. Jiang, J. Zhang, D. Liu, L. Zhang, X. Wang, T. Pan, H. Zhang, A. Wang, H.-W. Chao, Y. Jin, H. Chen, Circadian regulation of apolipoprotein gene expression affects testosterone production in mouse testis. Theriogenology, 2021 Oct. 15, Vol. 174, P9-19.
17. C.-W. Lin, D. Septyaningtrias¥, H.-W. Chao¥, M. Kond, K. Atarashi, K. Takeshita, K. Tamada, J. Nomura, Y. Sasagawa, K. Tanaka, I. Nikaido, K. Honda, T. J. McHugh and T. Takumi, A common epigenetic mechanism across different cellular origins underlies systemic immune dysregulation in autism. Molecular Psychiatry, under revise, (¥ Equal contribution)
Professional and Research Experience:
Dr. Kuo has long-standing interests in mucosal barrier function and mechanisms of epithelial death and survival. His doctoral work focused on how innate immune receptors regulate the formation of colorectal cancer and the therapeutic application via this molecular mechanism. Dr. Kuo’s post-doctoral research investigated the non-canonical function of tight junction proteins in maintaining host homeostasis.
Awards and Honors:
2021 Young Investigators Award. Crohn’s & Colitis Congress.
2019 Distinguished Research Recognition Award. The American Physiological Society,
2017 Excellent Research Award. National Taiwan University, College of Medicine
2016 Excellent Research Award. National Taiwan University, College of Medicine
2016 Research Award. Chinese Physiological Society
2015 Excellent Poster Award. Jung-Yaw Lin Science and Education Foundation
2015 Research Award. Chinese Physiological Society
2014 Research Award. Chinese Physiological Society
2012 Poster of Distinction. American Gastroenterological Association
2012 Graduate Academic Scholarship. Lungyen Social Welfare Charity Foundations
2010 Research Award. Chinese Physiological Society
2010 Graduate Academic Scholarship. Lungyen Social Welfare Charity Foundations
Selected Publications:
Kuo WT, Zuo L, Odenwald MA, Madha S, Singh G, Gurniak CB, Abraham C, Turner JR. The tight junction protein ZO-1 is dispensable for barrier function but critical for effective mucosal repair. Gastroenterology 2021. Online ahead of print. DOI 10.1053/j.gastro.2021.08.047. PMID 34478742
Chanez-Paredes SD, Abtahi S, Kuo WT, Turner JR. Differentiating between tight junction-dependent and tight junction-independent intestinal barrier loss in vivo. Methods in Molecular Biology (Clifton, NJ) 2021;2367:249-271. DOI 10.1007/7651_2021_389. PMID 33830456
Raju P, Shashikanth N, Tsai PY, Pongkorpsakol P, Chanez-Paredes S, Steinhagen PR, Kuo WT, Singh G, Tsukita S, Turner JR. Inactivation of paracellular cation-selective claudin-2 channels attenuates immune-mediated experimental colitis in mice. J Clin Invest 2020;130:5197-5208. DOI 10.1172/JCI138697. PMID 32516134
Rutlin M, Rastelli D, Kuo WT, Estep JA, Louis A, Riccomagno MM, Turner JR, Rao M. The villin1 gene promoter drives cre recombinase expression in extraintestinal tissues. Cell Mol Gastroenterol Hepatol 2020;10:864-867 e5. DOI 10.1016/j.jcmgh.2020.05.009. PMID 32464312
Zuo L, Kuo WT, Turner JR. Tight junctions as targets and effectors of mucosal immune homeostasis. Cell Mol Gastroenterol Hepatol 2020;10:327-340. DOI 10.1016/j.jcmgh.2020.04.001. (Co-first author). PMID 32304780
Kuo WT, Shen L, Zuo L, Shashikanth N, Ong M, Wu L, Zha J, Edelblum KL, Wang Y, Wang Y, Nilsen SP, Turner JR. Inflammation-induced occludin downregulation limits epithelial apoptosis by suppressing caspase-3 expression. Gastroenterology 2019;157:1323-1337. DOI 10.1053/j.gastro.2019.07.058. PMID 31401143
Zha JM, Li HS, Lin Q, Kuo WT, Jiang ZH, Tsai PY, Ding N, Wu J, Xu SF, Wang YT, Pan J, Zhou XM, Chen K, Tao M, Odenwald MA, Tamura A, Tsukita S, Turner JR, He WQ. Interleukin 22 expands transit-amplifying cells while depleting lgr5(+) stem cells via inhibition of wnt and notch signaling. Cell Mol Gastroenterol Hepatol 2019;7:255-274. DOI 10.1016/j.jcmgh.2018.09.006. PMID 30686779
Odenwald MA, Choi W, Kuo WT, Singh G, Sailer A, Wang Y, Shen L, Fanning AS, Turner JR. The scaffolding protein zo-1 coordinates actomyosin and epithelial apical specializations in vitro and in vivo. J Biol Chem 2018;293:17317-17335. DOI 10.1074/jbc.RA118.003908. PMID 30242130
Huang CY, Kuo WT, Huang CY, Lee TC, Chen CT, Peng WH, Lu KS, Yang CY, Yu LC. Distinct cytoprotective roles of pyruvate and atp by glucose metabolism on epithelial necroptosis and crypt proliferation in ischaemic gut. J Physiol 2017;595:505-521. DOI 10.1113/JP272208. PMID 27121603
Lu YZ, Huang CY, Huang YC, Lee TC, Kuo WT, Pai YC, Yu LC. Tumor necrosis factor alpha-dependent neutrophil priming prevents intestinal ischemia/reperfusion-induced bacterial translocation. Dig Dis Sci 2017;62:1498-1510. DOI 10.1007/s10620-017-4468-3. PMID 28144894
Tsai PY, Zhang B, He WQ, Zha JM, Odenwald MA, Singh G, Tamura A, Shen L, Sailer A, Yeruva S, Kuo WT, Fu YX, Tsukita S, Turner JR. Il-22 upregulates epithelial claudin-2 to drive diarrhea and enteric pathogen clearance. Cell Host Microbe 2017;21:671-681 e4. DOI 10.1016/j.chom.2017.05.009. PMID 28618266
Kuo WT, Lee TC, Yu LC. Eritoran suppresses colon cancer by altering a functional balance in toll-like receptors that bind lipopolysaccharide. Cancer Res 2016;76:4684-95. DOI 10.1158/0008-5472.CAN-16-0172. PMID 27328732
Kuo WT, Lee TC, Yu LC. Janus-faced bacterial regulation of epithelial cell death and survival: Association with colon carcinogenesis. Mol Cell Oncol 2016;3:e1029064. DOI 10.1080/23723556.2015.1029064. PMID 27308544
Kuo WT, Lee TC, Yang HY, Chen CY, Au YC, Lu YZ, Wu LL, Wei SC, Ni YH, Lin BR, Chen Y, Tsai YH, Kung JT, Sheu F, Lin LW, Yu LC. Lps receptor subunits have antagonistic roles in epithelial apoptosis and colonic carcinogenesis. Cell Death Differ 2015;22:1590-604. DOI 10.1038/cdd.2014.240. PMID 25633197
Wu LL, Peng WH, Kuo WT, Huang CY, Ni YH, Lu KS, Turner JR, Yu LC. Commensal bacterial endocytosis in epithelial cells is dependent on myosin light chain kinase-activated brush border fanning by interferon-gamma. Am J Pathol 2014;184:2260-74. DOI 10.1016/j.ajpath.2014.05.003. PMID 24911373
Yu LC, Shih YA, Wu LL, Lin YD, Kuo WT, Peng WH, Lu KS, Wei SC, Turner JR, Ni YH. Enteric dysbiosis promotes antibiotic-resistant bacterial infection: Systemic dissemination of resistant and commensal bacteria through epithelial transcytosis. Am J Physiol Gastrointest Liver Physiol 2014;307:G824-35. DOI 10.1152/ajpgi.00070.2014. PMID 25059827
Huang CY, Kuo WT, Huang YC, Lee TC, Yu LC. Resistance to hypoxia-induced necroptosis is conferred by glycolytic pyruvate scavenging of mitochondrial superoxide in colorectal cancer cells. Cell Death Dis 2013;4:e622. DOI 10.1038/cddis.2013.149. PMID 23640464
Yu LC, Huang CY, Kuo WT, Sayer H, Turner JR, Buret AG. Sglt-1-mediated glucose uptake protects human intestinal epithelial cells against giardia duodenalis-induced apoptosis. Int J Parasitol 2008;38:923-34. DOI 10.1016/j.ijpara.2007.12.004. PMID 18281046
Professional and Research Experience:
(8/2021- ) Assistant Professor, Graduate Institute of Biomedical Sciences, China Medical University
(9/2015-6/2021) Postdoctoral researcher, Center for Cell and Gene Therapy, Baylor College of Medicine, TX, USA
Awards and Honors:
Postdoctoral Fellowships: National Multiple Sclerosis Society (07/2017 - 06/2020)
Poster winner 3rd place, 25th Baylor College of Medicine Graduate Student Symposium (2013)
Presidential Award, National Taiwan University (10/2001 & 04/2003)
Selected Publications:
Ung K*, Huang TW*, Lozzi B, Woo J, Hanson E, Tepe B, Sardar D, Cheng YT, Pekarek B, Liua G, Deneen B, Arenkiel BR. “Olfactory bulb astrocytes mediate sensory circuit processing through Sox9 in the mouse brain”. Nat Commun. 2021 Jul; 12: 5230 *EQUAL CONTRIBUTION
Huang TW, Iyer AA, Manalo JM, Woo J, Bosquez Huerta NA, McGovern MM, Schrewe H, Pereira FA, Groves AK, Ohlemiller KK, Deneen B. “Glial-Specific Deletion of Med12 Results in Rapid Hearing Loss via Degradation of the Stria Vascularis”. J Neurosci. 2021 Jul; 41 (34) 7171-7181
Laug DJ*, Huang TW*, Bosquez Huerta NA, Huang YS, Sardar D, Ortiz-Guzman J, Carlson JC, Arenkiel B, Kuo CT, Mohila CA, Glasgow SM, Lee HK, Deneen B. “Nuclear factor I-A regulates diverse reactive astrocyte responses after CNS njury”. J Clin Invest. 2019 Oct 1;129(10):4408-4418. *EQUAL CONTRIBUTION
Wang J*, Wegener JE*, HUANG TW*, Sripathy S, De Jesus-Cortes H, Xu P, Tran S, Knobbe W1, Leko V, Britt J, Starwalt R, McDaniel L, Ward CS, Parra D, Newcomb B, Lao U, Nourigat C, Flowers DA, Cullen S, Jorstad NL, Yang Y, Glaskova L, Vigneau S, Kozlitina J, Yetman MJ, Jankowsky JL, Reichardt SD, Reichardt HM, Gärtner J, BartolomeiMS, Fang M, Loeb K, Keene CD, Bernstein I, Goodell M, Brat DJ, Huppke P, Neul JL, Bedalov A, Pieper AA. ”Wild-type microglia do not reverse pathology in mouse models of Rett syndrome”. Nature. 2015 May 21; 521(7552): E1-4. *EQUAL CONTRIBUTION
Professional and Research Experience:
2018-2021 Assistant Professor, University of Virginia School of Medicine, Charlottesville, VA, USA
2016-2018 Assistant Professor, Emory University School of Medicine, Atlanta, GA, USA
2015-2016 Research Associate, Emory University School of Medicine, Atlanta, GA, USA
-Study of neuroprotective mechanisms in neonatal brain injury: the discovery of the neuroprotective pathways and earlier diagnosis for developing effective therapies therapeutic strategy of neonatal hypoxia-ischemic encephalopathy (HIE), such as a new discovered blood biomarker and a brain-target therapy.
-Study of cerebral vascular pathophysiology in ischemic stroke: the exploration of pathophysiology in cerebral vessels, such as mechanisms of acute immune cell invasion-triggered neuroinflammation and cerebral blood flow (CBF) regulation.
Awards and Honors:
2018, National Institute of Neurological Disorders and Stroke grant
2017, American Heart Association (AHA) Scientist Development Grant
2014, American Heart Association (AHA) Postdoctoral Fellowship
2013, ISCBFM Young Investigator Travel Awards, International Symposium on Cerebral Blood Flow, Metabolism and Function
Selected Publications :
1. Kanchan Bisht, Kenneth A Okojie, Kaushik Sharma, Dennis H Lentferink, Yu-Yo Sun, Hong-Ru Chen, Joseph O Uweru, Saipranusha Amancherla, Zainab Calcuttawala, Antony Brayan Campos-Salazar, Bruce Corliss, Lara Jabbour, Jordan Benderoth, Bria Friestad, William A Mills 3rd, Brant E Isakson, Marie.veTremblay, Chia-Yi Kuan, Ukpong B Eyo (2021, Sep). Capillary-associated microglia regulate vascular structure and function through PANX1-P2RY12 coupling in mice. Nature Communications, 12(1):5289. (SCI, 5/128, ULTIDISCIPLINARY SCIENCES).
2. Tzenge-Lien Shih, Kuan-Hung Lin, Ray-Jade Chen, Ting-Yu Chen, Wei-Ting Kao, Jen-Wei Liu, Hsueh-Hsiao Wang, Hsien-Yu Peng, Yu-Yo Sun, Wan-Jung Lu (2021, Aug). A novel naphthalimide derivative reduces platelet activation and thrombus formation via suppressing GPVI. Journal of Cellular and Molecular Medicine, doi: 10.1111/jcmm.16886. Online ahead of print. (SCI, 41/188, MEDICINE, RESEARCH & EXPERIMENTAL).
3. Hong-Ru Chen, Xiaohui Zhang-Brotzge, Yury M. Morozov, Yuancheng Li, Siming Wang, Helen Zhang, Irena S. Kuan, Elizabeth M. Fugate, Hui Mao, Yu-Yo Sun, Pasko Rakic, Diana M. Lindquist, Ton DeGrauw, and Chia-Yi Kuan (2021, Jul). Creatine transporter deficiency impairs stress-adaptation and brain energetics homeostasis. JCI Insight, doi: 10.1172/jci.insight.140173. Online ahead of print. (SCI, 16/140, MEDICINE, RESEARCH & EXPERIMENTAL).
4. Vincent M Sciortino, Angela Tran, Naidi Sun, Rui Cao, Tao Sun, Yu-Yo Sun, Ping Yan, Fenghe Zhong, Yifeng Zhou, Chia-Yi Kuan, Jin-Moo Lee, Song Hu (2021, Jul). Longitudinal cortex-wide monitoring of cerebral hemodynamics and oxygen metabolism in awake mice using multi-parametric photoacoustic microscopy. Journal of Cerebral Blood Flow and Metabolism, doi: 10.1177/0271678X211034096. Online ahead of print. (SCI, 10/93, Hematology).
5. Yi-Min Kuo, Yu-Yo Sun, Chia-Yi Kuan (2021, Jun). A Fibrin-Enriched and tPA Sensitive Photothrombotic Stroke Model. Journal of Visualized Experiments, 4; (172). (SCI, 63/128, MULTIDISCIPLINARY SCIENCES).
6. Lori N Eidson, Qingzeng Gao, Hongyan Qu, Daniel S Kikuchi, Ana Carolina P Campos, Elizabeth A Faidley, Yu-Yo Sun, Chia-Yi Kuan, Rosana L Pagano, Bernard Lass.gue, Mal. G Tansey, Kathy K Griendling, Marina S Hernandes (2021, Mar). Poldip2 controls leukocyte infiltration into the ischemic brain by regulating focal adhesion kinase-mediated VCAM-1 induction. Scientific Reports, 1(1):5533. (SCI, 19/128, MULTIDISCIPLINARY SCIENCES).
7. Chia-Yi Kuan*, Hong-Ru Chen, Ning Gao, Yi-Min Kuo, Ching-Wen Chen, Dianer Yang, Melissa M Kinkaid, Erding Hu, Yu-Yo Sun* (2021, Jan). Braintargeted hypoxia-inducible factor stabilization reduces neonatal hypoxicischemic brain injury. Neurobiology of Disease, 148:105200. (SCI, 54/273, NEUROSCIENCES). *通訊作者.
8. Hong-Ru Chen, Ching-Wen Chen, Nandita Mandhani, Jonah C Short-Miller, Marchelle R Smucker, Yu-Yo Sun, Chia-Yi Kuan (2020, Dec). Monocytic Infiltrates Contribute to Autistic-like Behaviors in a Two-Hit Model of Neurodevelopmental Defects. Journal of Neuroscience, 40(49):9386-9400. (SCI, 52/273, NEUROSCIENCES).
9. Hong-Ru Chen, Yu-Yo Sun, Ching-Wen Chen, Yi-Min Kuo, Irena S Kuan, Zheng-Rong Tiger Li, Jonah C Short-Miller, Marchelle R Smucker, Chia-Yi Kuan (2020, Aug). Fate mapping via CCR2-CreER mice reveals monocyte-to microglia transition in development and neonatal stroke. Science Advances, 6(35):eabb2119. (SCI, 5/73, MULTIDISCIPLINARY SCIENCES).
10. Yu-Yo Sun*, Yi-Min Kuo*, Hong-Ru Chen, Jonah C Short-Miller, Marchelle R Smucker, Chia-Yi Kuan (2020, Apr). A murine photothrombotic stroke model with an increased fibrin content and improved responses to tPA-lytic treatment. Blood Advances, 4(7):1222-1231. (SCI, 13/76, HEMATOLOGY). *第一作者.
11. Chai-Ching Lin, Tien-Huang Chiang, Yu-Yo Sun, Muh-Shi Lin (2019, Mar). Protective Effects of CISD2 and Influence of Curcumin on CISD2 Expression in Aged Animals and Inflammatory Cell Model . Nutrients, 11(3):700. (SCI, 17/88, NUTRITION & DIETETICS).
12. Marina S Hernandes, Bernard Lass.gue, Lula L Hilenski, Jonathan Adams, Ning Gao, Chia-Yi Kuan, Yu-Yo Sun, Lihong Cheng, Daniel S Kikuchi, Manuel Yepes, Kathy K Griendling (2018, Feb). Polymerase delta-interacting protein 2 deficiency protects against blood-brain barrier permeability in the ischemic brain. Journal of Neuroinflammation, 15(1):45. (SCI, 23/273, NEUROSCIENCES).
13. Yu-Yo Sun*, Jolly Lee, Henry Huang, Mary B Wagner, Clinton H Joiner, David R Archer, Chia-Yi Kuan (2017, Dec). Sickle Mice Are Sensitive to Hypoxia/Ischemia-Induced Stroke but Respond to Tissue-Type Plasminogen Activator Treatment. Stroke, 48(12):3347-3355. (SCI, 16/208, CLINICAL NEUROLOGY). *第一作者
14. Enming Joseph Su, Chunzhang Cao, Linda Fredriksson, Ingrid Nilsson, Christina Stefanitsch, Tamara K Stevenson, Juanjuan Zhao, Margret Ragsdale, Yu-Yo Sun, Manuel Yepes, Chia-Yi Kuan, Ulf Eriksson, Dudley K Strickland, Daniel A Lawrence, Li Zhang (2017, Oct). Microglial-mediated PDGF-CC activation increases cerebrovascular permeability during ischemic stroke. Acta Neuropathologica, 134(4):585-604. (SCI, 5/273, NEUROSCIENCES).
15. Yikun Li, Eric B Dammer, Xiaohui Zhang-Brotzge, Scott Chen, Duc M Duong, Nicholas T Seyfried, Chia-Yi Kuan*, Yu-Yo Sun* (2017, Jan). Osteopontin Is a Blood Biomarker for Microglial Activation and Brain Injury in Experimental Hypoxic-Ischemic Encephalopathy. eNeuro, 4(1):ENEURO.0253-16.2016. (SCI, 110/273, NEUROSCIENCES). *通訊作者
Professional and Research Experience:
Research Associate and Postdoctoral Fellow, The Johns Hopkins University School of Medicine, Maryland, USA
Awards and Honors:
2018 Young Investigator and Travel Award, SYNGAP1/Neurodevelopmental Disorder Therapies meeting (NINDS-sponsored), Florida, USA
2016 Young Investigator and Travel Award, The International SYNGAP Conference (NINDS-sponsored), Texas, USA
2012 NARSAD Young Investigator Grant, Brain & Behavior Research Foundation, USA
Selected Publications:
Tan HL*, Chiu S-L*, Zhu Q*, and Huganir RL. 2020. GRIP1 regulates synaptic plasticity and learning and memory. Proc Natl Acad Sci USA 117(40): 25085-25091 (*: Equal contribution)
Mejias R, Chiu S-L, Han M, Rose R, Gil-Infante A, Zhao Y, Huganir RL, Wang T. 2019 Purkinje cell-specific Grip1/2 knockout mice show increased repetitive self-grooming and enhanced mGluR5 signaling in cerebellum. Neurobiology of Disease, 132:104602.
Wang Q, Chiu S-L*, Koropouli E*, Hong I*, Mitchell S, Easwaran TP, Hamilton N, Gustina A, Zhu Q, Ginty DD, Huganir RL, Kolodkin AL. 2017 Neuropilin-2/PlexinA3 receptors associate with GluA1 and mediate Sema3F-dependent homeostatic scaling in cortical neurons. Neuron 96(5): 1084-1098 (*: Equal contribution)
Chiu S-L, Diering G, Ye B, Takamiya K, Jiang Y, Niranjan T, Schwartz CE, Wang T and Huganir RL. 2017 GRASP1 regulates synaptic plasticity and memory through endosomal recycling of AMPA receptors. Neuron 93(6): 1405-1419
Han M, Mejias R, Chiu S-L, Rose R, Adamczyk, A, Huganir RL and Wang T. 2017 Mice lacking GRIP1/2 show increased social interactions and enhanced phosphorylations at GluA2-S880. Behavioural Brain Research 321: 176-84
Chen C-M, Orefice L*, Chiu S-L*, LeGates T, Hattar S, Huganir RL, Zhao H, Xu B and Kuruvilla R. 2017 Wnt5a is essential for hippocampal dendritic maintenance and spatial learning and memory in adult mice. Proc Natl Acad Sci USA 114(4): E619-28 (*: Equal contribution)
Professional and Research Experience:
台大醫學院解剖學暨細胞生物學研究所助理教授
陽明大學解剖學及細胞生物學研究所博士後研究員
陽明大學生理學研究所博士後研究員
Selected Publications:
1.Chin-Chuan Chen, Hung-Yuan Li, Yann-Lii Leu, Yu-Ju Chen, Chia-Jen Wang, Shu-Huei Wang* (2020, Apr). Corylin inhibits vascular cell inflammation, proliferation and migration and reduces atherosclerosis in ApoE-deficient mice. Antioxidants, 9(4), 275.
2.Chin-Chuan Chen, Chen-Hsin Kuo, Yann-Lii Leu, Shu-Huei Wang* (2020). Corylin reduces obesity and insulin resistance and promotes adipose tissue browning through SIRT-1 and β3-AR activation. Pharmacological research. 27:105291.
3.Chin-Chuan Chen, Ting-Yau Lee, Yann-Lii Leu, Shu-Huei Wang* (2019, Aug). Pigment epithelium-derived factor inhibits adipogenesis in 3T3-L1 adipocytes and protects against high-fat diet-induced obesity and metabolic disorders in
mice. Translational research, 210:26-42.
4.Hung-Yuan Li, Yann-Lii Leu, Ya-Chieh Wu, Shu-Huei Wang* (2019, Feb). Melatonin Inhibits in Vitro Smooth Muscle Cell Inflammation and Proliferation and Atherosclerosis in Apolipoprotein E-Deficient Mice. Journal of Agricultural and Food Chemistry, 67(7):1889-1901.
5.Shu-Huei Wang, Tse-Ya Yu, Feng-Chiao Tsai, Chris J Weston , Mao-Shin Lin, Chi-Sheng Hung, Hsien-Li Kao, Yu-I Li, Montse Sole, Mercedes Unzeta, Yuh-Lien Chen, Lee-Ming Chuang , Hung-Yuan Li (2018, Jul). Inhibition of semicarbazide-sensitive amine oxidase reduces atherosclerosis in apolipoprotein E-deficient mice. Transnational research, 197:12-31
Professional and Research Experience:
2016 Aug-Present 中山醫學大學 助理教授
2014 Jun- 2016 July 中央研究院分子生物研究所/中國醫藥大學 博士後研究員
2008 Dec- May 2014 國立臺灣大學 解剖學暨細胞生物學科暨研究所
2007 Sep- Dec 2008 英國東英格蘭大學 生物科學系
Awards and Honors:
1. 35屆生物醫學聯合年會 獲邀發表學術演講
2. 2020年 中山醫學大學醫學院最佳學術研究獎
3. 2019年 中山醫學大學醫學院新秀論文獎
4. 33屆生物醫學聯合年會 獲邀發表學術演講
5. 2018年 中山醫學大學醫學院新秀論文獎
Selected Publications:
1 Wen-Chieh Liao, Chih-Kai Liao, To-Jung Tseng, Ying‐Jui Ho, Ying-Ru Chen, Kuan-Hung Lin, Te‐Jen Lai, Chyn-Tair Lan, and Kuo-Chen Wei, Chiung-Hui Liu* (2020, Feb). Chondroitin sulfate synthase 1 enhances proliferation of glioblastoma by modulating PDGFRA stability. Oncogenesis, 9(9) page 1-11
2 Wen-Chieh Liao, Hung-Rong Yen, Chia-Hua Chen, Yin-Hung Chu, Ying‐Chyi Song, To-Jung Tseng, Chiung-Hui Liu* (2020,Dec). CHPF promotes malignancy of breast cancer cells by modifying syndecan-4 and the tumor microenvironment. Am J Cancer Res, (In press)
3 Wen-Chieh Liao, Hung-Rong Yen, Chih-Kai Liao, To-Jung Tseng, Chyn-Tair Lan, Chiung-Hui Liu* (2019, Jan) DSE regulates the malignant characters of hepatocellular carcinoma cells by modulating CCL5/CCR1 axis. Am J Cancer Res, 2019; 9(2): 347–362
4 Wen-Chieh Liao, Chih-Kai Liao, You-Huan Tsai, To-Jung Tseng, Li-Ching Chuang, Chyn-Tair Lan, Hung Ming Chang, Chiung-Hui Liu* (*Correspondence) (2018, Jun). DSE promotes aggressive glioma cell phenotypes by enhancing HB-EGF/ErbB signaling. Plos One, 13(6): e0198364
5 Chiung-Hui Liu, Chyn-Tair Lan, Jui-Feng Chou, To-Jung Tseng, Wen-Chieh Liao (2017, Sep). CHSY1 promotes aggressive phenotypes of hepatocellular carcinoma cells via activation of the hedgehog signaling pathway. Cancer Letters, Volume 403, Pages 280–288
Professional and Research Experience:
1. The mechanism of metastasis and apoptosis in the glioblastoma and bladder cancer cells
2. The effect of uremia toxin on muscle cells
Selected Publications:
1. Wang HH, Chen Y, Changchien CY, Chang HH, Lu PJ, Mariadas H, Cheng YC, Wu ST*. Pharmaceutical evaluation of honokiol and magnolol on apoptosis and migration inhibition in human bladder cancer cells. Front Pharmacol. 2020 Nov 6;11:549338.
2. Chang HH, Cheng YC, Tsai WC*, Chen Y*. PSMB8 inhibition decreases tumor angiogenesis in glioblastoma through VEGFA reduction. Cancer Sci. 2020 Nov. 111(11): 4142-4153.
3. Changchien CY, Chen Y, Chang HH, Chang SY, Tsai WC, Tsai HC, Wang CY, Lee HS, Tsai CL*. Effect of malignant-associated pleural effusion on endothelial viability, motility, and angiogenesis in lung cancer. Cancer Sci. 2020 Jul 24. ;111(10):3747-3758.
4. Changchien CY, Sung MH, Chang HH, Tsai WC, Peng YS*, Chen Y*. Uremic toxin indoxyl sulfate suppresses myocardial Cx43 assembly and expression via JNK activation. Chemico-Biological Interactions. 2020 Mar 1;319:108979.
5. Changchien CY, Lin YH, Cheng YC, Chang HH, Peng YS*, Chen Y*. Indoxyl sulfate induces myotube atrophy by ROS-ERK and JNK-MAFbx cascades. Chemico-Biological Interactions. 2019 Mar 5;304:43-51.
Professional and Research Experience:
Neuroscience, Alzheimer’s disease
Awards and Honors:
Global Young Scientists Summit 2019: Nominations
Poster Honorable Mention, 2017 The Taiwan Society for Biochemistry and Molecular Biology.
Excellent Research Award, College of Medicine, National Cheng Kung University. 2014 June.
2014 LiFu Medical Research, Culture, and Education Foundation Academia Award, Second place award, Taiwan Dementia Society
Selected Publications:
1. Yao-Hsiang Shih, Ling-Hsien Tu, Ting-Yu Chang, Kiruthika Ganesan, Wei-Wei Chang, Pao-Sheng Chang, Yu-Sheng Fang, Yeh-Tung Lin, Lee-Way Jin, Yun-Ru Chen (2020, Nov). TDP-43 interacts with amyloid-β, inhibits fibrillization, and worsens pathology in a model of Alzheimer’s disease. Nat Commun. 2020 Nov 23;11(1):5950.
2. Yao-Hsiang Shih, Shih-Ying Wu, Megan Yu, Sheng-Huai Huang, Chu-Wan Lee, Meei-Jyh Jiang, Pao-Yen Lin, Ting-Ting Yang, Yu-Min Kuo (2018, Mar). Hypertension Accelerates Alzheimers Disease-Related Pathologies in Pigs and 3xTg Mice. Front Aging Neurosci. 2018 Mar 20;10:73.
3. Ming-Hui Lee, Yao-Hsiang Shih, Sing-Ru Lin, Jean-Yun Chang, Yu-Hao Lin, Chun-I Sze, Yu-Min Kuo, Nan-Shan Chang (2017, Jun). Zfra restores memory deficits in Alzheimer's disease triple-transgenic mice by blocking aggregation of TRAPPC6AΔ, SH3GLB2, tau, and amyloid β, and inflammatory NF-κB activation. Alzheimers Dement (N Y). 2017 Mar 6;3(2):189-204.
4. Yao-Hsiang Shih, Sheng-feng Tsai, Yi-Ting Chiang,Michael W. Hughes, Shih-ying Wu, Chu-Wan Lee, Ting-Ting Yang, Yu-Min Kuo (2016, Feb). Hypertension impairs hippocampus-related adult neurogenesis, CA1 neuron dendritic arborization and long-term memory. Neuroscience. 2016 May 13;322:346-57.
5. Yao-Hsiang Shih, Kuen-Jer Tsai, Chu-Wan Lee,Shu-Chu Shiesh, Wei-Ting Chen, Ming-Chyi Pai, Yu-Min Kuo (2014, Feb). Apolipoprotein C-III is an Amyloid-β-Binding Protein and an Early Marker for Alzheimer's Disease. J Alzheimers Dis. 2014;41(3):855-65.
Professional and Research Experience:
1. Neuroscience/Nerve regeneration
2. Microsurgery and ischemic reperfusion injury
3. Sepsis and inflammation research
4. Exosome and microRNAs research
Awards and Honors:
Biomedical Journal, 2018「Most Cited Author Award」
Fellowship of the American College of Surgeons, FACS, since 2007
International Guest Scholarship 2005 from American College of Surgeons
Selected Publications:
Shao-Chun Wu, Pao-Jen Kuo, Cheng-Shyuan Rau, Yi-Chan Wu, Chia-Jung Wu, Tsu-Hsiang Lu, Chia-Wei Lin, Chia-Wen Tsai, Ching-Hua Hsieh*. Subpopulations of exosomes purified via different exosomal markers carry different microRNA contents. International Journal of Medical Sciences. 2021 Jan;18(5): 1058-1066.
Johnson Chia-Shen Yang, Shao-Chun Wu, Wei-Che Lin, Min-Hsien Chiang, Pi-Ling Chiang, Ching-Hua Hsieh*. Supermicrosurgical Lymphaticovenous Anastomosis as an Alternative Treatment Option for Moderate-to-Severe Lower Limb Lymphedema. Journal of the American College of Surgeons. 2020 Feb; 230(2): 216-227.
Pao-Jen Kuo, Cheng-Shyuan Rau, Shao-Chun Wu, Tsu-Hsiang Lu, Yi-Chan Wu, Peng-Chen Chien, Chia-Jung Wu, Chia-Wei Lin, Chia-Wen Tsai, Ching-Hua Hsieh*, Chun-Ying Huang. Metagenomic analysis of the effects of toll-like receptors on bacterial infection in the peritoneal cavity following cecum ligation and puncture in mice. PLos One. 2019 Jul; 14(7): e0220398.
Cheng-Shyuan Rau, Shao-Chun Wu, Tsu-Hsiang Lu, Yi-Chan Wu, Chia-Jung Wu, Peng-Chen Chien, Pao-Jen Kuo, Chia-Wei Lin, Chia-Wen Tsai, Ching-Hua Hsieh*. Effect of Low-Fat Diet in Obese Mice Lacking Toll-like Receptors. Nutrients. 2018 Oct; 10(10): E1464.
Shao-Chun Wu, Cheng-Shyuan Rau, Hang-Tsung Liu, Pao-Jen Kuo, Peng-Chen Chien, Ting-Min Hsieh, Ching-Hua Tsai, Jung-Fang Chuang, Chun-Ying Huang, Hsiao-Yun Hsieh, Ching-Hua Hsieh*. Metagenome Analysis as a Tool to Study Bacterial Infection Associated with Acute Surgical Abdomen. Journal of Clinical Medicine. 2018 Oct; 7(10): E346.
Professional and Research Experience:
Assistant Professor, School of Dentistry, China Medical University, Aug 2016 - now
Associate Research Fellow, x-Dimension Center for Medical Research and Translation, China Medical University Hospital, Dec 2017 – now
Assistant Research Fellow, 3D Printing Medical Research Center, China Medical University Hospital, Oct 2014 – Nov 2017
Awards and Honors:
The 17th National Innovation Award, Research Center for Biotechnology and Medicine Policy, Taiwan.
2020-Young Investigator Competition Award, The Biomaterials and Controlled Release Society
The 16th National Innovation Award, Research Center for Biotechnology and Medicine Policy, Taiwan.
Selected Publications:
Kao CT, Chiu YC, Lee KX, Lin YH, Huang TH, Liu YC, Shie MY. The synergistic effects of Xu Duan combined Sr-contained calcium silicate/poly-ε-caprolactone scaffolds for the promotion of osteogenesis marker expression and the induction of bone regeneration in osteoporosis. Materials Science and Engineering: C 2021;119:111629.
Lin FS, Lee JJ, Lee KX, Ho CC, Liu YT, Shie MY. Calcium silicate-activated gelatin methacrylate hydrogel for accelerating human dermal fibroblast proliferation and differentiation. Polymers 2021;13:70.
Chen YW, Shie MY, Hsiao CH, Wang B, Liang YC, Chen IW. Synthesis of high-quality monolayer tungsten disulphide with chlorophylls and its application for enhancing bone regeneration. npj 2D Materials and Applications 2020;4:34.
Chen YW, Wang K, Ho CC, Kao CT, Ng HY, Shie MY. The mechanism of the synergistic effect on cyclic tensile force and NGF stimulation of Schwann cell-laden auxetic hydrogel scaffolds for nerve regeneration. Mater Design 2020;195:108982.
Chen YW, Chen CC, Ng HY, Lou CW, Chen YS, Shie MY. Additive manufacturing of nerve decellularized extracellular matrix-contained polyurethane conduits for peripheral nerve regeneration. Polymers 2019;11:1612
Professional and Research Experience:
Postdoctoral Fellow: Institute of Molecular Biology, Academia Sinica
Assistant Professor: Department of Cell Biology and Anatomy, National Cheng Kung University
Joint Appointment Associate Professor: Department of Physiology, National Cheng Kung University
Awards and Honors:
108學年度國立成功大學教學優良教師
105學年度醫學系教學優良教師
Selected Publications:
1. Ting-Yu Chen, Bu-Miin Huang, Tang K. Tang, Yu-Ying Chao, Xiao-Yi Xiao, Pei-Rong Lee, Li-Yun Yang, and Chia-Yih Wang; Genotoxic stress-activated DNA-PK-p53 cascade and autophagy cooperatively induce ciliogenesis to maintain the DNA damage response, Cell Death and Differentiation. 2021, Epub ahead of print.
2. Ting-Yu Chen, Tzu-Chien Lin, Pao-Lin Kuo, Zi-Rong Chen, Hui-ling Cheng, Yu-Ying Chao, Jhih-Siang Syu, Fu-I Lu, and Chia-Yih Wang; Septin 7 is a centrosomal protein that ensures S phase entry and microtubule nucleation by maintaining the abundance of p150glued, Journal of Cellular Physiology. 2021, 236:2706–2724.
3. Ting‐Yu Chen, Wei‐Chih Lien, Hui‐Ling Cheng, Ta‐Shen Kuan, Shi‐Yuan Sheu, and Chia‐Yih Wang; Chloroquine inhibits human retina pigmented epithelial cell growth and microtubule nucleation by downregulating p150glued, Journal of Cellular Physiology. 2021, 234:10445–10457.
4. Wei-Chih Lien, Ting-Yu Chen, Shi-Yuan Sheu, Tzu-Chien Lin, Fu-Chi Kang, Chung-Hsing Yu, Ta-Shen Kuan, Bu-Miin Huang, and Chia-Yih Wang; 7-hydroxy-staurosporine, UCN-01, induces DNA damage response and autophagy in human osteosarcoma U2-OS cells. Journal of Cellular Biochemistry, 2015, 119, 4729-4741.
Professional and Research Experience:
馬偕醫學院生物醫學研究所 專任助理教授(2013/2-2019/1)
國家衛生研究院 細胞及系統醫學研究所 助理研究學者 (2012/8-2013/1)
國家衛生研究院 細胞及系統醫學研究所 博士後研究員 (2006/1-2012/7)
Selected Publications:
Yi-Feng Lin, Hung-Ching Lin, Chia-Ling Tsai, Yi-Chao Hsu*. GJB2 Mutation Spectrum in the Taiwanese Population and Genotype–Phenotype Comparisons in Patients with Hearing Loss Carrying GJB2 c.109G>A and c.235delC Mutations. Hearing Research. Vol.108135:1-10. Nov. 2020. (SCI)
Chang KH, Tsai SC, Lee CY, Chou RH, Fan HC, Lin FC, Lin CL, Hsu YC*. Increased Risk of Sensorineural Hearing Loss as a Result of Exposure to Air Pollution. Int J Environ Res Public Health. Vol.17:6-6. Mar. 2020. (SCI)
Lu HE, Tsai CL, Chiu IM, Pan YL, Lin YF, Lin HC, Hsu YC*. Generation of induced pluripotent stem cells MMCi001-A from a Taiwanese hearing loss patient carrying GJB2 pV37I mutation.. Stem Cell Research. Vol.42:1692-1692. Jan. 2020. (SCI)
Chen YC, Tsai CL, Wei YH, Wu YT, Hsu WT, Lin HC, Hsu YC*. ATOH1/RFX1/RFX3 transcription factors facilitate the differentiation and characterisation of inner ear hair cell-like cells from patient-specific induced pluripotent stem cells harbouring A8344G mutation of mitochondrial DNA. Cell Death Dis. Vol.9:437-440. Apr. 2018. (SCI)
Hsu YC, Chen SL, Wang YJ, Chen YH, Wang DY, Chen I, Chen CH, Chiu IM. Signaling adaptor protein SH2B1 enhances neurite outgrowth and accelerates the maturation of human induced neurons. Stem Cells Translational Medicine. Vol.6:713-722. Jun. 2014. (SCI)
Professional and Research Experience:
Dr. Yeh’s current research interests include ultrasound molecular theranostics and ultrasound physics. Dr. Yeh collaborated with researchers in the areas of biology, genes, and cancer and assessed tumor theranostics using self-designed ultrasound imaging system and contrast agents. Dr. Yeh proposed the concept of smart, multifunctional ultrasound contrast agents capable of facilitating focus ultrasound while serving as drug carrying vehicles and protecting drugs from rapid degradation for tumor treatment. Now, he is a senior member of IEEE, technical program committee of IEEE International Ultrasonics Symposium (IUS) and served as convener of Biomedical Engineering of Taiwan MOST from 2019 to 2021.
Awards and Honors:
Future Tech Awards, Ministry of Science and Technology, Academia Sinica, Ministry of Education, and Ministry of Health and Welfare, Taiwan, September, 2021. (未來科技獎)
Outstanding Research Award, Ministry of Science and Technology, Taiwan, April, 2020. (科技部 傑出研究獎)
Industry/University Cooperative Research Award, National Tsing Hua University, Taiwan, November, 2014.
Academic Achievement Award (清華大學教師學術卓越獎勵), National Tsing Hua University, Taiwan, 2009-present.
National Innovation Award (國家新創獎, 學術研究組), Institute for Biotechnology and Medicine Industry (國家生技醫療產業策進會), Taiwan, August, 2011.
Dr. Wu Da-You Memorial Award, National Science Council, Taiwan, August, 2010. (科技部 吳大猷紀念獎)
Selected Publications:
145 research papers
Professional and Research Experience:
Mr. I-Jan Chen is the Co-founder and the Chairman of Southport co. Ltd. After getting his bachelor's degree in computer science at National Chiao Tung University, he changed his interest to physics. In the first year of the graduate school of Electro-physics in NCTU, he published a series of experimental work on spintronics and nano-magnetism in nanowire and quantum dot. A new theoretical model, which included the quantum confinement effect into mean-field theory, to describe the giant internal magnetic field in magnetic atom doped quantum dot was established and proved by experiment in his research. After receiving his master's degree and finishing the military service, Mr. Chen built up the world's first Radio-frequency Scanning tunneling microscope during the research assistant work in the Center of Condensed Matter Sciences at National Taiwan University.
His interdisciplinary experience and observation of future technology trends led him to start up the Southport Co. Ltd. with other 3 co-founders in Sep. 2014. The spirit and specialty of Southport are to use the cross-disciplinary knowledge, including optics, material science, and biomedical science, with the new electro-optic technology of digital optics, also known as software-defined optics, to identify and solve the problems in microscopic imaging in different fields of applications. In the last seven years, Southport has accomplished in-vivo high-speed imaging, in-vivo neuroimaging, super-resolution imaging, nanomaterial inspection, quantum light source, compound semiconductor inspection, and 3D microstructure imaging. In 2021, The first software-defined microscope, named Fourier microscope, has been announced by Southport. This is the first time an all-in-one optical microscope can communicate with the digital world, including AI, or other software technologies.
Awards and Honors:
2008 Excellent Thesis Award for Graduate Students of the Physical Society of the Republic of China (Taiwan)
2010 Outstanding Soldier Medal of the National Army of the ROC.
44th Silver Medal of National Army Literature and Art Award
2013 FITI Innovation and Entrepreneurship Incentive Competition, Entrepreneurial Excellence Award
2020 Golden Peak Award of Innovative Research and development of The Year
2020 Golden Peak Award of Enterprise Initiators of The Year
28th Taiwan Small and Medium Enterprises Innovation Award
Selected Publications:
"Radio Frequency Reflectometry Scanning Tunneling Microscope" US (US88663311), Taiwan, German, and China patents granted
"Radio-frequency reflectometry scanning tunneling microscope " US 9304146
"Size Effects on Thermal Treatment and Room-Temperature Ferromagnetism in High-Vacuum Annealed ZnCoO Nanowires", J. Phys. Chem. C 112, 9168 (2008)
"Cross-Sectional Shape Modulation of Physical Properties in ZnO and Zn1-xCoxO Nanowires", New J. Phys.10, 033017 (2008)
“Size-dependent magnetization and high-vacuum annealing enhanced ferromagnetism in Zn1-xCoxO nanowires”, J. Nanosci. Nanotechnol. 8, 202 (2008)
“Effects of heat treatment of selective laser melting printed ti-6al-4v specimens on surface texture parameters and cell attachment” Applied Sciences (Switzerland). March 2021, 11, 5, p. 1-14 14 p., 2234.
Professional and Research Experience:
02/2018－07/2020, Assistant Professor, Department of Biomedical Imaging and Radiological Sciences, National Yang-Ming University, Taipei, Taiwan
08/2017－01/2018, Assistant Professor, Department of Anatomy and Cell Biology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan
09/2014－07/2017, Assistant Research Fellow/ Chief Executive Officer, Translational Imaging Research Center, College of Medicine, Taipei Medical University, Taipei, Taiwan
08/2013－08/2014, Assistant Professor, Department of Physical Therapy and Assistive Technology, National Yang-Ming University, Taipei, Taiwan
Awards and Honors:
Faculty Academic Excellence Awards, College of Biomedical Science and Engineering, National Yang Ming Chiao Tung University, 2021-2023.
Featured Teaching Excellence Award (Computer Sciences), National Yang Ming Chiao Tung University, 2021.
College Outstanding Teaching Award, College of Biomedical Science and Engineering, National Yang-Ming University, 2020.
Research of Excellence, Young Investigator Awards for Pediatric Neuropsychiatric Science, President Award of National Health Research Institutes, 2019.
Selected Publications:
Chia-Feng Lu, Fei-Ting Hsu, Kevin Li-Chun Hsieh, Yu-Chieh Jill Kao, Sho-Jen Cheng, Bo-Kai Hsu, Ping-Huei Tsai, Ray-Jade Chen, Chao-Ching Huang, Yun Yen, Cheng-Yu Chen. Machine Learning-Based Radiomics for Molecular Subtyping of Gliomas. Clinical Cancer Research, 24(18):4429-4436, 2018. (IF=12.531, Q1)
Huai-Che Yang, Chih-Chun Wu, Cheng-Chia Lee, Huai-En Huang, Wei-Kai Lee, Wen-Yuh Chung, Hsiu-Mei Wu, Wan-Yuo Guo, Yu-Te Wu, Chia-Feng Lu*. Prediction of Pseudoprogression and Long-term Outcome of Vestibular Schwannoma after Gamma Knife Radiosurgery based on Preradiosurgical MR Radiomics. Radiotherapy and Oncology, 155:123-130, 2021. (IF=6.280, Q1)
Chien-Yi Liao, Cheng-Chia Lee, Huai-Che Yang, Ching-Jen Chen, Wen-Yuh Chung, Hsiu-Mei Wu, Wan-You Guo, Ren-Shyan Liu, Chia-Feng Lu*. Enhancement of Radiosurgical Treatment Outcome Prediction Using MRI Radiomics in Patients with Non-Small Cell Lung Cancer Brain Metastases. Cancers, 13:4030, 2021 (IF=6.639, Q1)
Wei-Kai Lee, Chih-Chun Wu, Cheng-Chia Lee, Chia-Feng Lu, Huai-Che Yang, Tzu-Hsuan Huang, Chun-Yi Lin, Wen-Yuh Chung, Po-Shan Wang, Hsiu-Mei Wu, Wan-Yuo Guo, Yu-Te Wu. Combining analysis of multi-parametric MR images into a convolutional neural network: precise target delineation for vestibular schwannoma treatment planning. Artificial Intelligence in Medicine, 107:101911, 2020. (IF=4.383, Q1)
Chien-Yi Liao, Jun-Hsuang Jen, Yi-Wei Chen, Chien-Ying Li, Ling-Wei Wang, Ren-Shyan Liu, Wen-Sheng Huang*, Chia-Feng Lu*, Comparison of Conventional and Radiomic Features between 18F-FBPA PET/CT and PET/MR. Biomolecules, 11, 1659, 2021. (IF=4.879, Q2)
Professional and Research Experience:
Molecular-Genetic Imaging of Small Animal
Nuclear Oncology
Neuronuclear Medicine
Nuclear Endocrinology
Emergency Medical Planning and Management of Radiation Accident
Awards and Honors:
2011 The Outstanding Research Award, Taipei Veterans General Hospital.
1995 The Outstanding Research Award, (Intra-arterial I-131 lipiodol and
histoacryl in treatment of hepatoma), Atomic Energy Council, R.O.C.
Selected Publications:
Chen YA, Li JJ, Lin SL, Lu CH, Chiu SJ, Jeng FS, Chang CW, Yang BH, Chang MC, Ke CC, Liu RS*. Effect of Cerenkov Radiation-Induced Photodynamic Therapy with 18F-FDG in an Intraperitoneal Xenograft Mouse Model of Ovarian Cancer. Int. J. Mol. Sci. 2021, 22(9), 4934; https://doi.org/10.3390/ijms22094934
Chen YA, Lu CH, Ke CC, Chiu SJ, Jeng FS, Chang CW, Yang BH, Liu RS*. Mesenchymal Stem Cell-Derived Exosomes Ameliorate Alzheimer’s Disease Pathology and Improve Cognitive Deficits. Biomedicines 2021, 9, 594. https://doi.org/10.3390/biomedicines9060594.
Chen YA, Lu CH, Ke CC, Chiu SJ, Chang CW, Yang BH, Gelovani JG, Liu RS*. Evaluation of Class IIa Histone Deacetylases Expression and In Vivo Epigenetic Imaging in a Transgenic Mouse Model of Alzheimer’s Disease; Int. J. Mol. Sci. 2021;22(16), 8633. https://doi.org/10.3390/ijms22168633
Chen YA, Ho CL, Ku MT, Hue L, Lu CH, Chiu SJ, Chang WY and Liu RS*. Detection of Cancer Stem Cells by EMT-Specific Biomarker-based Peptide Ligands. Scientific Reports 2021;17;11(1):2243, 2021.
Chen YA, Lu CH, Ke CC and Liu RS*. Mesenchymal Stem Cell-Derived Extracellular Vesicle-Based Therapy for Alzheimer’s Disease: Progress and Opportunity. Membranes 2021; 11(10), 796
